grant
Trpv4 regulation of lymphatic vascular function: Implications in metabolic syndrome
Organization TULANE UNIVERSITY OF LOUISIANALocation NEW ORLEANS, UNITED STATESPosted 20 Mar 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2026AD dementiaAgonistAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAreaBiological MarkersBloodBlood Reticuloendothelial SystemBlood VesselsBody TissuesCD140a AntigensCOVID-19CV-19CalciumCardiovascular DiseasesCell BodyCell FunctionCell JunctionsCell PhysiologyCell ProcessCell-Extracellular MatrixCellsCellular FunctionCellular PhysiologyCellular ProcessClinicalConfocal MicroscopyContracting OpportunitiesContractsCoronavirus Infectious Disease 2019DataDiseaseDisorderDysfunctionECMEndothelial CellsEnsureExtracellular MatrixFeedbackFibrosisFluid BalanceFluid HomeostasisFunctional disorderHealthImmuneImmunesImpairmentInflammationInflammatoryInflammatory ResponseIntercellular JunctionsIon ChannelIonic ChannelsIschemic Brain InjuryLeannessLinkLipid TraffickingLiquid substanceLung damageLymph SystemLymphaticLymphatic Endothelial CellsLymphatic EndotheliumLymphatic NetworkLymphatic SystemLymphatic System Reticuloendothelial SystemLymphatic TissueLymphatic functionLymphoid TissueMediatingMembrane ChannelsMetabolic dysfunctionMetabolic syndromeMiceMice MammalsMurineMusMyographyObese MiceObesityPAI-1PAI1PDGF alpha ReceptorPDGF receptor αPDGF-R-alphaPDGFR-αPDGFRαPLANH1PhysiopathologyPlasminogen Activator Inhibitor 1Platelet-Derived Growth Factor Receptor Alpha PolypeptidePlatelet-Derived Growth Factor alpha ReceptorPrimary Senile Degenerative DementiaPumpReceptor ProteinRegulationResearchRoleSerine or Cysteine Proteinase Inhibitor Clade E Member 1SpeedStretchingSubcellular ProcessTamoxifenTestingTherapeuticThinnessTissuesType 1 Plasminogen Activator InhibitorVanilloidVascular DiseasesVascular DisorderWild Type Mouseadiposityantagonismantagonistbio-markersbiologic markerbiomarkerblood vessel disordercardiovascular disordercell typecoronavirus disease 2019coronavirus disease-19coronavirus infectious disease-19corpulencediet-associated obesitydiet-induced obesitydiet-related obesityfat metabolismfluidimprovedin vivoinduced Creinducible Creinhibitorischemic brain damagelipid metabolismlipid transportliquidlung injurylymph channellymph vessellymphatic channellymphatic dysfunctionlymphatic impairmentlymphatic vasculaturelymphatic vesselnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachob/ob mousepathophysiologypharmacologicplatelet-derived growth factor receptor αpressurepreventpreventingprimary degenerative dementiapromoterpromotorprotein expressionpulmonary damagepulmonary injurypulmonary tissue damagepulmonary tissue injuryreceptorsenile dementia of the Alzheimer typesocial rolevascularvascular dysfunctionvasculopathywestern dietwestern-style dietwestern-type dietwildtype mouse
Description preview
PROJECT SUMMARY
A major function of the lymphatic system is fluid transport, which is critical for fluid homeostasis, lipid transport
and metabolism, and the transport of immune cells and pro-inflammatory molecules. Lymphatic vessels contract
spontaneously to pump fluid, while intraluminal one-way valves ensure net forward flow. Our group and…
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