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tRNA-derived RNA Fragments (tRF) as Prognostic and Diagnostic Biomarkers for Alzheimer’s Disease

Organization UNIVERSITY OF TEXAS MED BR GALVESTONLocation GALVESTON, UNITED STATESPosted 15 Mar 2023Deadline 28 Feb 2026 ⚠️
NIHUS FederalResearch GrantFY2025AD dementiaAD pathologyAD preventionActive Follow-upAddressAffectAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer disease preventionAlzheimer disease screeningAlzheimer preventionAlzheimer sclerosisAlzheimer screeningAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's biomarkerAlzheimer's diagnosisAlzheimer's disease biological markerAlzheimer's disease diagnosisAlzheimer's disease pathologyAlzheimer's disease patientAlzheimer's disease therapeuticAlzheimer's pathologyAlzheimer's patientAlzheimer's therapeuticAlzheimers DementiaAlzheimer’s biological markerAlzheimer’s disease biomarkerAmentiaAmmon HornAmyloidAmyloid SubstanceAmyotrophic Lateral SclerosisAmyotrophic Lateral Sclerosis Motor Neuron DiseaseAnticodonAssayBioassayBioinformaticsBiologicalBiological AssayBiological MarkersBiometricsBiometryBiostatisticsBloodBlood PlasmaBlood Reticuloendothelial SystemBlood SerumBody TissuesBrainBrain Nervous SystemCerebrospinal FluidClinicalClinical EvaluationClinical ServicesClinical TestingCognitiveCognitive Retention DisordersCornu AmmonisDataDegenerative Neurologic DisordersDementiaDevelopmentDiseaseDisease ProgressionDisorderEncephalonEpidemiologic ResearchEpidemiologic StudiesEpidemiological StudiesEpidemiology ResearchEvaluationFDG PETFamilyFunctional RNAFutureGehrig's DiseaseGenesGoalsHippocampusHumanIndividualLeadLongitudinal StudiesLou Gehrig DiseaseMT-bound tauMachine LearningMemory DisordersMemory LossMethodsMicroRNAsModalityModern ManMonitorNational Institute of AgingNational Institute on AgingNerve DegenerationNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuron DegenerationNeuropsychologiesNeuropsychologyNon-Polyadenylated RNANoncoding RNANontranslated RNAPETPET ScanPET imagingPETSCANPETTParalysis AgitansParentsParkinsonParkinson DiseasePatientsPb elementPeripheralPersonsPhasePlasmaPlasma SerumPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPreventionPrimary ParkinsonismPrimary Senile Degenerative DementiaProcessPrognosisPrognostic MarkerPublicationsQualifyingQuantitative RTPCRQuantitative Reverse Transcriptase PCRRNARNA Gene ProductsRNA NucleasesRNA SeqRNA sequencingRNAseqRNaseRad.-PETReportingResearchReticuloendothelial System, Serum, PlasmaRibonuclease Family ProteinRibonucleasesRibonucleic AcidRoleSamplingScanningScientific PublicationScreening procedureSerumSeverity of illnessSmall RNATestingTissuesTransfer RNATranslational ResearchTranslational ScienceTreatment EfficacyTriplet Codon-Amino Acid AdaptorUntranslated RNAVisitactive followupagedangiogeninbio-markersbiologicbiologic markerbiomarkerbiomarker arraybiomarker panelblood-based biomarkerblood-based markerbrain MR imagingbrain MRIbrain magnetic resonance imagingcerebral MR imagingcerebral MRIcerebral magnetic resonance imagingcerebral spinal fluidclinical testcognitive assessmentcognitive functioncognitive testingdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentaldiagnostic biomarkerdiagnostic markerdiagnostic tooldifferential expressiondifferentially expresseddisease diagnosisdisease diagnosticdisease preventiondisease severitydisorder preventionendonucleaseepidemiologic investigationepidemiology studyexperiencefeature selectionfluorodeoxyglucose PETfluorodeoxyglucose positron emission tomographyfollow upfollow-upfollowed upfollowupheavy metal Pbheavy metal leadhippocampalimprovedinsightintervention efficacylong-term studylongitudinal outcome studiesmachine based learningmarker panelmemory declinemiRNAmicrotubule bound taumicrotubule-bound taumild cognitive disordermild cognitive impairmentmolecular biomarkermolecular markerneural degenerationneural imagingneuro-imagingneurodegenerationneurodegenerativeneurodegenerative illnessneuroimagingneurological degenerationneurological imagingneuronal degenerationneuropsychologicnew diagnosticsnext generation diagnosticsnon-alzheimer's associated dementianon-alzheimer's disease associated dementianon-alzheimer's disease dementianon-alzheimer's disease related dementianon-alzheimer's related dementianonalzheimer dementianonalzheimer's disease associated dementianoncodingnovelnovel diagnosticsp-taup-τparentpatient living with Alzheimer's diseasepatient suffering from Alzheimer's diseasepatient with Alzheimer'spatient with Alzheimer's diseasephospho-tauphospho-τphosphorylated taupositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypost-translational modification of tauposttranslational modification of taupre-clinicalpreclinicalprimary degenerative dementiaprognosticprognostic biomarkerprognostic indicatorqRTPCRresearch clinical testingscreening toolssenile dementia of the Alzheimer typeskillssocial rolespinal fluidtRNAtautau Proteinstau factortau phosphorylationtau posttranslational modificationtau-1therapeutic efficacytherapy efficacytranscriptional differencestranscriptome sequencingtranscriptomic sequencingtransfer Ribonucleic acidstranslation researchtranslational investigationτ Proteinsτ phosphorylation

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PROJECT SUMMARY/ABSTRACT
tRNA-derived RNA Fragments (tRFs), a newly discovered family of non-coding RNAs (ncRNAs), are emerging
as essential disease biomarkers and regulators. Our recent publication demonstrated that tRFs are the most
impacted small ncRNAs (sncRNAs) by Alzheimer's disease (AD) in the hippocampus. The changes are mainly
from five…

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