grant
tRNA-derived RNA Fragments (tRF) as Prognostic and Diagnostic Biomarkers for Alzheimer’s Disease
Organization UNIVERSITY OF TEXAS MED BR GALVESTONLocation GALVESTON, UNITED STATESPosted 15 Mar 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2026AD biological markerAD biomarkerAD dementiaAD pathologyAD patientsAD preventionAD related biomarkerAD screeningAD therapyAD treatmentActive Follow-upAddressAffectAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer disease preventionAlzheimer disease screeningAlzheimer disease treatmentAlzheimer preventionAlzheimer sclerosisAlzheimer screeningAlzheimer syndromeAlzheimer treatmentAlzheimer'sAlzheimer's DiseaseAlzheimer's biomarkerAlzheimer's diagnosisAlzheimer's disease biological markerAlzheimer's disease biomarkerAlzheimer's disease diagnosisAlzheimer's disease pathologyAlzheimer's disease patientAlzheimer's disease related biomarkerAlzheimer's disease therapeuticAlzheimer's disease therapyAlzheimer's pathologyAlzheimer's patientAlzheimer's related biomarkerAlzheimer's therapeuticAlzheimer's therapyAlzheimers DementiaAlzheimer’s biological markerAmentiaAmmon HornAmyloidAmyloid SubstanceAmyotrophic Lateral SclerosisAmyotrophic Lateral Sclerosis Motor Neuron DiseaseAnticodonAssayBioassayBioinformaticsBiologicalBiological AssayBiological MarkersBiometricsBiometryBiostatisticsBloodBlood PlasmaBlood Reticuloendothelial SystemBlood SerumBody TissuesBrainBrain Nervous SystemCerebrospinal FluidClinicalClinical EvaluationClinical ServicesClinical TestingCognitiveCognitive Retention DisordersCornu AmmonisDataDegenerative Neurologic DisordersDementiaDevelopmentDiseaseDisease ProgressionDisorderEncephalonEpidemiologic ResearchEvaluationFDG PETFamilyFunctional RNAFutureGehrig's DiseaseGenesGoalsHippocampusHumanIndividualLeadLongitudinal StudiesLongitudinal SurveysLou Gehrig DiseaseMT-bound tauMachine LearningMemory DisordersMemory LossMethodsMicroRNAsModalityModern ManMonitorNational Institute of AgingNational Institute on AgingNerve DegenerationNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuron DegenerationNeuropsychologiesNeuropsychologyNon-Polyadenylated RNANoncoding RNANontranslated RNAPETPET ScanPET imagingPETSCANPETTParalysis AgitansParentsParkinsonParkinson DiseasePatientsPb elementPeripheralPersonsPhasePlasmaPlasma SerumPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPreventionPrimary ParkinsonismPrimary Senile Degenerative DementiaProcessPrognosisPrognostic MarkerPublicationsQualifyingQuantitative RTPCRQuantitative Reverse Transcriptase PCRRNARNA Gene ProductsRNA NucleasesRNA SeqRNA sequencingRNAseqRNaseRad.-PETReportingResearchReticuloendothelial System, Serum, PlasmaRibonuclease Family ProteinRibonucleasesRibonucleic AcidRoleSamplingScanningScientific PublicationScreening procedureSerumSeverity of illnessSmall RNATestingTissuesTransfer RNATranslational ResearchTranslational ScienceTreatment EfficacyTriplet Codon-Amino Acid AdaptorUntranslated RNAVisitactive followupagedangiogeninbio-markersbiologicbiologic markerbiomarkerbiomarker arraybiomarker in ADbiomarker in Alzheimer'sbiomarker in Alzheimer's diseasebiomarker panelblood-based biomarkerblood-based markerbrain MR imagingbrain MRIbrain magnetic resonance imagingcerebral MR imagingcerebral MRIcerebral magnetic resonance imagingcerebral spinal fluidclinical testcognitive assessmentcognitive functioncognitive testingdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentaldiagnostic biomarkerdiagnostic markerdiagnostic tooldifferential expressiondifferentially expresseddisease diagnosisdisease diagnosticdisease preventiondisease severitydisorder preventionendonucleaseepidemiologic investigationexperiencefeature selectionfluorodeoxyglucose PETfluorodeoxyglucose positron emission tomographyfollow upfollow-upfollowed upfollowupheavy metal Pbheavy metal leadhippocampalimprovedinsightintervention efficacyinvestigate epidemiologylong-term studylongitudinal outcome studieslongitudinal research studymachine based learningmarker panelmemory declinemiRNAmicrotubule bound taumicrotubule-bound taumild cognitive declinemild cognitive disordermild cognitive dysfunctionmild cognitive impairmentmild cognitive lossmild neurocognitive impairmentmolecular biomarkermolecular markerneural degenerationneural imagingneuro-imagingneurodegenerationneurodegenerativeneurodegenerative illnessneuroimagingneurological degenerationneurological imagingneuronal degenerationneuropsychologicnew diagnosticsnext generation diagnosticsnon-alzheimer's associated dementianon-alzheimer's disease associated dementianon-alzheimer's disease dementianon-alzheimer's disease related dementianon-alzheimer's related dementianonalzheimer dementianonalzheimer's disease associated dementianoncodingnovelnovel diagnosticsp-taup-τparentpatient living with Alzheimer's diseasepatient suffering from Alzheimer's diseasepatient with Alzheimer'spatient with Alzheimer's diseasepatients with ADphospho-tauphospho-τphosphorylated taupositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypost-translational modification of tauposttranslational modification of taupre-clinicalpreclinicalprimary degenerative dementiaprognosticprognostic biomarkerprognostic indicatorqRTPCRresearch clinical testingscreening toolssenile dementia of the Alzheimer typeskillssocial rolespinal fluidstudy epidemiologysurvey epidemiologytRNAtautau Proteinstau factortau phosphorylationtau posttranslational modificationtau-1therapeutic efficacytherapy efficacytranscriptional differencestranscriptome sequencingtranscriptomic sequencingtransfer Ribonucleic acidstranslation researchtranslational investigationτ Proteinsτ phosphorylation
Description preview
PROJECT SUMMARY/ABSTRACT
tRNA-derived RNA Fragments (tRFs), a newly discovered family of non-coding RNAs (ncRNAs), are emerging
as essential disease biomarkers and regulators. Our recent publication demonstrated that tRFs are the most
impacted small ncRNAs (sncRNAs) by Alzheimer's disease (AD) in the hippocampus. The changes are mainly
from five…
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