grant
Treatment of Neonatal Hypoxic Ischemic Injury with Echogenic Noble Gas Microbubbles
Organization NEW JERSEY INSTITUTE OF TECHNOLOGYLocation NEWARK, UNITED STATESPosted 6 May 2026Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY20260-11 years oldAMPA ReceptorsAcquired brain injuryActive OxygenAcuteAfter CareAfter-TreatmentAftercareAmmon HornAnimal ModelAnimal Models and Related StudiesAnimalsApoptoticAr elementAreaArgonBBB penetrationBehavior DisordersBehavioralBlood - brain barrier anatomyBlood leukocyteBlood-Brain BarrierBody TissuesBrainBrain Hypoxia-IschemiaBrain InjuriesBrain Nervous SystemBrain TraumaCarotid ArteriesCell BodyCell Communication and SignalingCell DeathCell ProtectionCell SignalingCell membraneCellsCerebral PalsyCerebrovascular systemChemotactic CytokinesChildChild YouthChildren (0-21)ClinicalCognitiveCombined Modality TherapyCommon Rat StrainsCornu AmmonisCytoplasmic MembraneCytoprotectantsCytoprotectionCytoprotective AgentCytoprotective DrugsD-GlucoseDevelopmentDextroseDiffuseDiscipline of obstetricsDrug DeliveryDrug Delivery SystemsERK 1ERK1ERK1 KinaseESI geneESI proteinEchographyEchotomographyElastase-Specific InhibitorEmotional disorderEncapsulatedEncephalonEpilepsyEpileptic SeizuresEpilepticsEquilibriumExtracellular Signal-Regulated Kinase 1ExtravasationFemaleGasesGliaGlial CellsGlucoseGlutamate ReceptorGoalsGroup 18 ElementsHealthHemato-Encephalic BarrierHippocampusHistologicHistologicallyHomologous Chemotactic CytokinesHospitalsHumanHypothermiaHypoxic-Ischemic Brain InjuryImageIn VitroIndividualInert GasesInfarctionInflammatoryInhalationInhalingInjuryIntercrinesIntracellular Communication and SignalingIntravenousInvestigatorsIonsIschemiaIschemia-Reperfusion InjuryKolliker's reticulumLeakageLeucocytic infiltrateLeukocytesLeukocytes Reticuloendothelial SystemLocationMAP Kinase 3MAPK3MAPK3 Mitogen-Activated Protein KinaseMAPK3 geneMarrow leukocyteMeasuresMedical UltrasoundMemoryMetabolicMicrobubblesMitochondriaMitogen-Activated Protein Kinase 3Mitogen-Activated Protein Kinase 3 GeneModelingModern ManMonitorMorbidityMultimodal TherapyMultimodal TreatmentN-Methyl-D-Aspartate ReceptorsN-Methylaspartate ReceptorsNMDA Receptor-Ionophore ComplexNMDA ReceptorsNeonatal asphyxia-induced brain injuryNeonatal hypoxic brain injuryNerve CellsNerve DegenerationNerve UnitNervous System PhysiologyNeural CellNeurocyteNeurogliaNeuroglial CellsNeurologic DeficitNeurologic functionNeurological disabilityNeurological functionNeuron DegenerationNeuronsNeuroprotectantsNeuroprotective AgentsNeuroprotective DrugsNoble GasesNon-neuronal cellNonneuronal cellO elementO2 elementObstetricsOccluding JunctionsOutcomeOxygenOxygen RadicalsP44ERK1PI3PI3 genePSTkinase p44mpkPathway interactionsPerformancePhysiologic pulsePlasma MembranePro-OxidantsPropertyProteinase Inhibitor 3ProteinsProtocolProtocols documentationPublic HealthPulseRare GasesRatRats MammalsRattusReactive Oxygen SpeciesRecoveryReperfusion DamageReperfusion InjuryReperfusion TherapyResearchResearch PersonnelResearch ProposalsResearchersRuptureSIS cytokinesSKALPSafetySeizure DisorderSeizuresSensorimotor functionsSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSpillageStructureTRAPPIN 2TechniquesTestingTherapeuticTight JunctionsTimeTissuesTransducersTranslationsTraumatic Brain InjuryTreatment ProtocolsTreatment RegimenTreatment ScheduleTreatment outcomeUltrasonic ImagingUltrasonogramUltrasonographyUltrasound DiagnosisUltrasound Medical ImagingUltrasound TestWhite Blood CellsWhite CellWorkXe elementXenonZonula Occludensbalancebalance functionbehavior testbehavioral disorderbehavioral testbiological signal transductionblood vessels in the brainblood-brain barrier penetrationbloodbrain barrierbloodbrain barrier penetrationbrain blood vesselsbrain damagebrain vasculaturebrain-injuredcerebral arterycerebral blood vesselcerebral vasculaturecerebrovascular vesselscerebrovasculaturechemoattractant cytokinechemokineclinically approved drugclinically approved medicationclinically approved therapeutic agentcombination therapycombined modality treatmentcombined treatmentcytokinecytoprotectivedeprivationdevelopmentaldiagnostic ultrasounddosagedrug candidateearly clinical trialearly phase clinical trialelafinepilepsiaepileptogenicexcitotoxicexcitotoxicityexperiencegas elementglial activationglial cell activationhippocampalhypoxia/ischemiahypoxic ischemic encephalopathyhypoxic ischemic injuryimage guidanceimage guidedimagingimprovedin vivoin vivo Modelinfarctinjuredinjurieskidsmalemitochondrialmodel of animalmorris water mazemorris watermazemortalitymulti-modal therapymulti-modal treatmentnatural hypothermianecrocytosisneonatal HIEneonatal brain hypoxia-ischemianeonatal careneonatal hypoxia-ischemianeonatal hypoxic-ischemic brain damageneonatal hypoxic-ischemic brain injuryneonatal hypoxic-ischemic encephalopathynerve cementnervous system functionneural degenerationneurodegenerationneurodegenerativeneurological degenerationneuronalneuronal degenerationneuroprotectionneuroprotectivenew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyp44 MAPKpathwayplasmalemmapost treatmentpostnatalpre-clinicalpreclinicalpreservationpreventpreventingpupreceptor bindingreceptor boundrecruitreperfusionside effectsite targeted deliveryskin-derived antileukoproteinasesonogramsonographysound measurementtargeted deliverytherapeutically effectivetranslationtraumatic brain damageultrasoundultrasound imagingultrasound scanningwhite blood cellwhite blood corpusclewhite matter damageyoungster♀♂
Description preview
The major health significance of this proposal is the delivery and local release of therapeutic gases from
echogenic microbubbles using ultrasound as a novel treatment for neonatal hypoxic-ischemic (HI)
encephalopathy. Hypoxic-ischemic encephalopathy (HIE) is a major cause of mortality and long-term
neurological disabilities in children including…
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