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Treatment Approaches and Outcomes in Pouch-related Disorders after Colectomy for Ulcerative Colitis
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 5 Feb 2021Deadline 30 Nov 2025 ⚠️
NIHUS FederalResearch GrantFY2025(TNF)-αAcuteAddressAffectAnalAnastomosisAnastomosis - actionAnti-Tumor Necrosis Factor TherapyAnusAreaAwardBig DataBigDataBiological Response Modifier TherapyBiological TherapyCachectinCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesChronicClinicalClinical DataClinical InvestigatorClinical ResearchClinical SciencesClinical StudyClinical TrialsColectomyColitisComparative Effectiveness ResearchCounselingCrohn diseaseCrohn'sCrohn's diseaseCrohn's disorderCrowdingCurative SurgeryDataDevelopmentDevelopment PlansDiagnosisDiseaseDisorderDysplasiaEducational workshopEnsureEnvironmentEpidemiologyFacultyFoundationsFrequenciesFundingFutureGoalsGranulomatous EnteritisIleal PouchesIleal ReservoirsInflammatoryInflammatory Bowel DiseasesInflammatory Bowel DisorderInstitutionInvestigatorsK-AwardsK-Series Research Career ProgramsK23 AwardK23 MechanismK23 ProgramKnowledgeLaboratoriesMachine LearningMacrophage-Derived TNFMedicalMentored Patient-Oriented Research Career Development AwardMentored Patient-Oriented Research Career Development Award (K23)MentorsMentorshipMethodsModelingMonocyte-Derived TNFMultiomic DataNational Institutes of HealthNorth CarolinaOperative ProceduresOperative Surgical ProceduresOutcomeOutcome AssessmentPatient CarePatient Care DeliveryPatient Outcomes AssessmentsPatient Reported MeasuresPatient Reported OutcomesPatientsPeer ReviewPopulationPositionPositioning AttributePouch IleitisPouchitisPrediction of Response to TherapyPreventative strategyPrevention strategyPreventive strategyPrivatizationProductivityProspective cohortQOLQualitative ResearchQuality of lifeR-Series Research ProjectsR01 MechanismR01 ProgramRefractoryRegistriesReportingResearchResearch Career ProgramResearch GrantsResearch MethodologyResearch MethodsResearch PersonnelResearch Project GrantsResearch ProjectsResearchersRestorative ColoproctectomyRestorative ProctocolectomyRiskRisk FactorsScientistStructureSurgicalSurgical InterventionsSurgical ProcedureSymptom BurdenSymptomsTNFTNF ATNF AlphaTNF geneTNF therapyTNF-αTNFATNFαTechniquesTimeTrainingTranslational ResearchTranslational ScienceTreatment ProtocolsTreatment RegimenTreatment ScheduleTumor Necrosis FactorTumor Necrosis Factor TherapyTumor Necrosis Factor-alphaUlcerated ColitisUlcerative ColitisUnited States National Institutes of HealthUniversitiesWorkWorkshopWritinganti-TNF therapyanti-TNF-alpha therapybiological therapeuticbiological treatmentbiologically based therapeuticsbiotherapeuticsbiotherapycandidate selectioncare for patientscare of patientscareercareer developmentcaring for patientsclinical carecognitive interviewcomparative effectivenesscomparative effectiveness studydata collected in real worlddesigndesigningdevelopmentaldyscrasiaeffectiveness researcheffectiveness studyeleocolitisepidemiologicepidemiologicalexperiencefecal microbiomegastrointestinalhigh riskhigher educationimprovedindexingindividual patientinflammatory disease of the intestineinflammatory disorder of the intestineinstrumentinterestintestinal autoinflammationmachine based learningmachine learning based methodmachine learning methodmachine learning methodologiesmembermicrobial consortiamicrobial floramicrobiotamicrofloramultiple omic datamultispecies consortianew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoutcome predictionpatient oriented researchpatient oriented studyprecision medicineprecision-based medicinepredict therapeutic responsepredict therapy responsepredictive signatureprospectivereal world dataregional enteritisresearch and methodsresponseskillsstool microbiomestool-associated microbiomesurgerytherapy predictiontooltranslation researchtranslational investigationtreatment predictiontreatment response predictiontreatment strategy
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PROJECT SUMMARY
This overall goal of this mentored patient-oriented research career development award is to improve our
understanding of pouchitis and other inflammatory conditions after restorative proctocolectomy with ileal
pouch-anal anastomosis (IPAA). Dr. Barnes is a motivated clinical researcher at the University of North
Carolina at Chapel…
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