grant
Translational Research Program on PFAS and Metabolic Diseases: A Solution Oriented Framework
Organization UNIVERSITY OF SOUTHERN CALIFORNIALocation Los Angeles, UNITED STATESPosted 10 Apr 2026Deadline 31 Mar 2034
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DAddressAdult-Onset Diabetes MellitusAffectAreaBiologicalBiological MarkersBloodBlood Reticuloendothelial SystemChemicalsChronic DiseaseChronic IllnessCommunitiesComplexDataData ScienceData SetEarly identificationEnsureEnvironmental ExposureEnvironmental HealthEnvironmental Health ScienceEnvironmental PollutantsEpidemiological dataEpidemiology dataExposure toHealthHepatic DisorderHumanIn VitroIntermediary MetabolismInterventionIntervention StrategiesKetosis-Resistant Diabetes MellitusKnowledgeLeadershipLinkLiverLiver diseasesMaturity-Onset Diabetes MellitusMetabolicMetabolic DiseasesMetabolic DisorderMetabolic ProcessesMetabolismModelingModern ManNIDDMNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusObesityOutcomePFASParticipantPathway interactionsPoly-fluoroalkyl substancesPreventative strategyPrevention strategyPreventive strategyResearchRiskRisk AssessmentSlow-Onset Diabetes MellitusStable Diabetes MellitusT2 DMT2DT2DMTechniquesThesaurismosisTranslatingTranslational Research EnterpriseTranslationsType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesadiposityadult onset diabetesbio-markersbiologicbiologic markerbiomarkerchronic disordercohortcommunity engagementcommunity interventioncommunity level interventioncommunity-based interventioncorpulencedata integrationdisease riskdisorder riskengagement with communitiesenvironmental contaminantepidemiologic dataepidemiologic discoveriesexposure to environmental agentsexposure to environmental factorsexposure to environmental stimuliexposure to environmental substancesflexibilityflexiblehepatic body systemhepatic diseasehepatic organ systemhepatopathyin vitro Modelinnovateinnovationinnovativeketosis resistant diabeteslife spanlifespanliver disordermaturity onset diabetesmetabolism disordermultiomicsmultiple omicspanomicspathwayperfluorinated alkyl substancesperfluoroalkyl substancesperfluoroalkylated substancespolyfluorinated alkyl substancespolyfluoroalkyl substancesprogramspublic health prioritiesscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingthree dimensionaltissue culturetooltranslationtranslation research enterprisetranslational modeltranslational research programtype 2 DMtype II DMtype two diabetes
Description preview
ABSTRACT
This R35 application aims to revolutionize precision environmental health in a model research program addressing the complex health risks posed by per- and polyfluoroalkyl substances (PFAS), with a focus on metabolic diseases such as obesity, type 2 diabetes, and metabolic-associated steatotic liver disease (MASLD). PFAS, known as…
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