grant
Translational approaches to unravel organ-specific microvascular endothelial responses in sepsis.
Organization CINCINNATI CHILDRENS HOSP MED CTRLocation CINCINNATI, UNITED STATESPosted 1 Jul 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY20260-11 years oldAddressAtlasesAutoregulationBasic ResearchBasic ScienceBiologicalBiological MarkersBlood PlasmaBlood VesselsBody TissuesCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCandidate Disease GeneCandidate GeneCas nuclease technologyCell BodyCellsChildChild YouthChildren (0-21)ClinicalClottingClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCoagulationCoagulation ProcessCollaborationsCoupledCritical IllnessCritically IllData SetDevelopmentDrugsDysfunctionEndothelial CellsEndotheliumEvolutionFailureFunctional disorderFundingFutureGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGenesHeterogeneityHomeostasisHumanHypoxiaHypoxicImmune responseIn VitroInfectionInflammationInjuryInstitutionKnowledgeLaboratoriesLaboratory ResearchLifeMedicationMedicineModelingModern ManNIGMSNational Institute of General Medical SciencesNatureOrganOrgan SpecificityOrganoidsOutcomeOxygen DeficiencyPatientsPharmaceutical PreparationsPhysiological HomeostasisPhysiopathologyPlasmaPlasma SerumPre-Clinical ModelPrecision therapeuticsPreclinical ModelsPublishingRecoveryResearchResolutionResource SharingReticuloendothelial System, Serum, PlasmaSamplingScientistSepsisSeptic ShockTechnical ExpertiseTestingThrombosisTissuesTranscript Expression AnalysesTranscript Expression AnalysisTranslationsVascular EndotheliumWhole Bloodadvanced diseaseadvanced illnessanalyze gene expressionantisepsis treatmentbio-markersbiologicbiologic markerbiomarkerchildren with sepsisdevelopmentaldisease modeldisorder modeldrug/agentendothelial dysfunctiongene editing platformgene editing systemgene editing technologygene editing toolsgene expression analysisgene expression assaygene-editing toolkithiPSChost responsehuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellsimmune system responseimmunoresponseimprovedimproved outcomeinduced human pluripotent stem cellsinjuriesinjury to tissuekidsmortalitypathophysiologypatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypespediatric sepsispediatric septicprecision therapiesprecision treatmentprogramsresolutionsresponserisk stratificationsepsis caresepsis in childrensepsis interventionssepsis managementsepsis therapeuticssepsis therapysepsis treatmentseptic childrenseptic therapyseptic treatmentstratify risksystemic inflammationsystemic inflammatory responsetargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttechnical skillsthrombotic diseasethrombotic disordertissue injurytranscriptional profilingtranscriptomicstranslationtranslation strategytranslational approachtranslational strategytreat sepsisvascularyoungster
Description preview
Translational approaches to unravel organ-specific microvascular endothelial responses in sepsis.
PROGRAM SUMMARY:
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to an
infection and is associated with high mortality. Systemic inflammation and endothelial activation with resultant
microvascular leak,…
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