grant
Translating buccal nanocytology for lung cancer screening into clinical practice
Organization NORTHWESTERN UNIVERSITYLocation Chicago, UNITED STATESPosted 15 Apr 2018Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY20253-D analysis3-dimensional analysis3D analysisAI AugmentedAI assistedAI basedAI drivenAI enhancedAI integratedAI poweredActive Follow-upAdenocarcinomaAgeAir PollutionAlgorithmsArchitectureArtificial Intelligence enhancedAugmented by AIAugmented by the AIAugmented with AIAugmented with the AIBMIBMI percentileBMI z-scoreBiological MarkersBody mass indexBrush CellBuccaBuccal MucosaCAT scanCT X RayCT XrayCT imagingCT scanCancer DetectionCancer InductionCancerousCancersCaringCausalityCell BodyCellsCessation of lifeCheekCheek structureChromatinChromatin StructureClinical ResearchClinical StudyClinical TrialsComputed TomographyDNADataData SetDeathDemographic FactorsDeoxyribonucleic AcidDetectionDevelopmentDiagnosisDiagnosticDiseaseDisorderDistantDropsEarly DiagnosisElectron MicroscopyElectronsEligibilityEligibility DeterminationEngineering / ArchitectureEnsureEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEtiologyEuchromatinEvaluationExposure toFemaleFosteringFundingFutureGasesGenderGene TranscriptionGeneral PopulationGeneral PublicGenetic TranscriptionGenome MappingsGenomicsGoalsHeterochromatinHistologicHistologicallyHistologyHistonesHomeImageImmune mediated therapyImmunologically Directed TherapyImmunotherapyLabelLengthLesionLinkLungLung Respiratory SystemMalignant AdenomaMalignant NeoplasmsMalignant TumorMalignant Tumor of the LungMalignant neoplasm of lungMeasurableMeasurementMeasuresMethodsMicroscopyMolecularMolecular ConfigurationMolecular ConformationMolecular StereochemistryMouth MucosaMucosaMucosal TissueMucous MembraneNanoscopyNegative Beta ParticleNegatronsOperative ProceduresOperative Surgical ProceduresOpticsOral MucosaOral mucous membrane structurePatientsPatternPerformancePhenotypePlayPopulationPrecancerous CellsPredictive ValuePremalignant CellProtocol ScreeningPulmonary CancerPulmonary malignant NeoplasmQuetelet indexRNA ExpressionRaceRacesRadonRecommendationRegulationRiskRisk FactorsRn elementRoboticsRoleScanningSelf AdministeredSelf AdministrationSeriesSmokerSmoking HistorySourceSpecificityStage at DiagnosisSurgicalSurgical InterventionsSurgical ProcedureSwabTechniquesTechnologyTestingThree-dimensional analysisTimeTobaccoTomodensitometryTracheaTrachea ProperTranscriptionTranslatingTransmissionValidationX-Ray CAT ScanX-Ray Computed TomographyX-Ray Computerized TomographyXray CAT scanXray Computed TomographyXray computerized tomographyactive followupagesartificial intelligence assistedartificial intelligence augmentedartificial intelligence basedartificial intelligence drivenartificial intelligence integratedartificial intelligence poweredbio-markersbiologic markerbiomarkercandidate biomarkercandidate markercarcinogenesiscatscancausationchemo-/radio-therapychemo-radiotherapychemoradiationchemoradiation therapychemoradiation treatmentchemoradiotherapyclinical practiceclinical translationclinical validationclinically translatablecohortcomputed axial tomographycomputer tomographycomputerized axial tomographycomputerized tomographyconformationconformationalconformational alterationconformational stateconformationallyconformationscostcost effectivedeep learningdeep learning methoddeep learning strategydemographicsdevelopmentaldiagnostic technologiesdisease causationearly detectionearly screeningelectron tomographyenhanced with AIenhanced with Artificial Intelligenceepigeneticallyfollow upfollow-upfollowed upfollowuphomesimagingimaging spectroscopyimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyindustrial partnershipindustry partnerindustry partnershipinterestliquid biopsylung cancerlung cancer early detectionlung cancer screeninglung carcinogenesismalemalignancyminimally invasivemortalitynano meter scalenano meter sizednano-sized sensorsnanocytologynanoimagingnanometer scalenanometer sizednanoscalenanosensingnanosensorsneoplasm/cancerneoplasticnew approachesnon-compliancenon-compliantnon-contrast CTnon-smokernon-smokingnoncompliancenoncompliantnoncontrast CTnoncontrast computed tomographynonsmokernonsmokingnovel approachesnovel strategiesnovel strategyopticaloral mucosaeoral mucosalpack/yearprecancerprecancerouspremalignantpreservationprimary care settingprospectiveracialracial backgroundracial originradio-chemo-therapyradio-chemotherapyradiochemotherapyrecommended screeningscreeningscreening guidelinesscreening recommendationsscreening uptakescreeningssensing technologysensor technologysensor-based technologysimulationsingle moleculesocial rolespectroscopic imagingsurgerytech developmenttechnology developmenttheoriestranscriptomicstransmission processtumorvalidationswindpipe♀♂
Description preview
The overarching goal of this Academic-Industrial Partnership is to develop an at-home, self-administered lung
cancer screening test based on the analysis of chromatin architecture in cells swabbed from the buccal (cheek)
mucosa, which can identify patients at risk for early-stage lung cancer who may benefit from definitive follow up
evaluation…
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