grant
Transformative lightsheet microscopy techniques for subcellular imaging in physiologically relevant 3D environments
Organization UNIVERSITY OF NEW MEXICOLocation ALBUQUERQUE, UNITED STATESPosted 1 Sept 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAddressArchitectureBindingBiologicalBiological FunctionBiological ProcessBiologyBody TissuesCell BodyCell CommunicationCell InteractionCell-to-Cell InteractionCellsCharacteristicsClassificationColorComplexCoupledCouplingDataDevelopmentDiseaseDisorderDisseminated Malignant NeoplasmEngineeringEngineering / ArchitectureEnvironmentEventHealthIlluminationImageImaging DeviceImaging InstrumentImaging ToolInvestigatorsLabelLightLightingMalignant CellMetastatic CancerMetastatic Malignant NeoplasmMethodsMicroscopeMicroscopyMolecularMolecular InteractionMorphologyOpticsOrganOrganismOrganoidsOutcomePatternPenetrationPhenotypePhotoradiationPhysiologicPhysiologicalResearchResearch PersonnelResearch SpecimenResearchersResolutionSample SizeSamplingScanningSpecimenSpeedSystematicsTechniquesTechnologyTimeTissue imagingTissuesUV laboratory microscopeUltraviolet Microscopesadaptive opticsbiologiccancer cellcancer microenvironmentcell typedesigndesigningdevelopmentalfluorescence microscopefluorescence/UV microscopefluorescent microscopefluorophorehigh resolution imagingimage-based methodimagingimaging methodimaging modalityimprovedinterestlaboratory fluorescence light microscopelive cell imagelive cell imaginglive cellular imagelive cellular imagingliving systemmillimeterminimally invasivenext generationnoveloptic imagingopticaloptical imagingpreventpreventingprogramsresolutionsresponse to therapyresponse to treatmentspatial and temporalspatial temporalspatiotemporalspheroidstemporal measurementtemporal resolutiontherapeutic responsetherapeutic targettherapy responsethree dimensionaltime measurementtreatment responsetreatment responsivenesstumor microenvironmentuser-friendly
Description preview
Abstract
Optical imaging enables fast and minimally invasive observation of biological processes within living cells and
organisms. However, current state-of-the-art imaging instruments have limitations in acquisition speed, spatial resolution
and light-penetration depth that restrict the types of biological questions that can be addressed. This…
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