grant
Transcriptional and epigenetic mechanisms of alveologenesis and re-alveologenesis
Organization CINCINNATI CHILDRENS HOSP MED CTRLocation CINCINNATI, UNITED STATESPosted 15 Mar 2024Deadline 28 Feb 2031
NIHUS FederalResearch GrantFY2026Acute Lung InjuryAcute Pulmonary InjuryAlveolusBioinformaticsBlood capillariesBronchial AlveolusBronchopulmonary DysplasiaCOVID-19CV-19Cause of DeathCell BodyCell Communication and SignalingCell FunctionCell LineageCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessCoronavirus Infectious Disease 2019DevelopmentEndotheliumEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpitheliumFoundationsFunctional RNAGWA studyGWASGasesGene TranscriptionGenetic TranscriptionInjuryIntracellular Communication and SignalingKnowledgeLungLung DiseasesLung Respiratory SystemMesenchymalNoncoding RNANontranslated RNAOrganPopulationPulmonary DiseasesPulmonary DisorderPulmonary HypertensionRNA ExpressionReaction TimeRegulationResponse RTResponse TimeSignal TransductionSignal Transduction SystemsSignalingSubcellular ProcessTranscriptionUntranslated RNAVariantVariationbiological signal transductionburden of diseaseburden of illnesscapillarycell typechronic lung disease in infantschronic lung disease in neonatal infantschronic lung disease in neonateschronic lung disease in newbornschronic lung disease in prematuritychronic lung disease in preterm infantschronic lung disease of infancychronic lung disease of prematuritycoronavirus disease 2019coronavirus disease-19coronavirus infectious disease-19developmentaldisease burdendisease of the lungdisorder of the lungepigeneticallyfunctional genomicsgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studyinfant chronic lung diseaseinfants with chronic lung diseaseinjurieslung disordermouse geneticsneonatal chronic lung diseasenewborn chronic lung diseasenoncodingnovelpost-prematurity respiratory diseasepreterm infants with chronic lung diseasepsychomotor reaction timesingle cell genomicssingle cell technologywhole genome association analysiswhole genome association study
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PROJECT SUMMARY
Lung diseases impacting the gas exchange alveoli, including COVID-19, are becoming the leading cause
of death. A multi-lineage, transcriptional, and epigenetic understanding of alveologenesis and re-
alveologenesis upon injury is a timely response to the disease burden and leverages latest single-cell
technology. My lab’s track…
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