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Toward therapeutic targeting of liquid-liquid phase separation dynamics in skin

Organization EMORY UNIVERSITYLocation ATLANTA, UNITED STATESPosted 3 Apr 2023Deadline 2 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldAccelerationAddressAdrenal Cortex HormonesAdultAdult HumanAffectArchitectureAtopic DermatitisAtopic EczemaAtopic NeurodermatitisBehaviorBiotinBiotinylationCalcineurin antagonistCalcineurin inhibitorCatalogsCell NucleusCharacteristicsChildChild YouthChildren (0-21)CorticoidsCorticosteroidsCouplingCutaneous DisorderCutaneous imagingCytoplasmic GranulesCytosolDNA mutationDefectDermatological ImagingDermatosesDestinationsDiseaseDisorderDisseminated NeurodermatitisEngineeringEngineering / ArchitectureEpidermisEventExonsFoundationsFutureGene DeliveryGenesGenetic ChangeGenetic DiversityGenetic VariationGenetic defectGenetic mutationGenetic studyGoalsGranular LayerHealthHistidineHumanHuman GeneticsImmuneImmunesImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImpairmentInflammationInflammatoryLabelLengthLinkLiquid substanceMapsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMembraneModelingModern ManMolecularMonoclonal Antibody TherapyMutationNatureNonsense MutationNucleusOrganellesPathogenesisPathologicPatientsPhasePhysical condensationPhysiologicPhysiologicalProcessProtein EngineeringProteinsProteomicsRecurrenceRecurrentResearchRoleSkinSkin DiseasesSkin Diseases and ManifestationsSkin ImagingSkin repairStratificationStratum GranulosumStratum corneum basic proteinTestingTherapeuticTyrosineVariantVariationViscosityVitamin HWorkadulthoodallergic dermatitisallergic eczemabiochemical toolsbiochemistry toolscatalogchronic inflammatory skincoenzyme Rcondensationcornificationcutaneous barriercutaneous diseasecutaneous repairdermal barrierdermal diseasedermal disorderdermal repairdesigndesigningdruggable targetepidermal barrierexperimentexperimental researchexperimental studyexperimentsfilaggrinfilagrinfluidgenetic protein engineeringgenome mutationgranuleimaging approachimaging based approachimmune suppressionimmune suppressive activityimmune suppressive functionimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseinnovateinnovationinnovativeinsightkeratinizationkeratinocytekeratinocyte differentiationkeratohyalinkidsliquidlive cell imagelive cell imaginglive cellular imagelive cellular imagingloss of functionloss of function mutationmAB-based therapymAb therapymAb-based therapeuticsmembrane structurenon-sense mutationnovelpreventpreventingprogramsprotein designrestraintskin barrierskin disordersocial rolestandard of caretherapeutic targettoolyoungster

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PROJECT SUMMARY
Atopic dermatitis (AD) is a chronic inflammatory skin disorder that affects 15-20% of children and 1-3%

of adults worldwide. The current standard-of-care for AD involves the use of calcineurin inhibitors,

corticosteroids, and monoclonal antibody therapies that curb inflammation through immunosuppression.

However, extensive genetic…

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Toward therapeutic targeting of liquid-liquid phase separation dynamics in skin β€” EMORY UNIVERSITY | UNITED STATES | Apr | Dev Procure