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Tolerance defenses in host-microbiota interactions

Organization SALK INSTITUTE FOR BIOLOGICAL STUDIESLocation La Jolla, UNITED STATESPosted 10 May 2015Deadline 31 Mar 2026 ⚠️

NIHUS FederalResearch GrantFY2025AcuteAdaptive Immune SystemAddressAffectAntibody ResponseAttenuatedBehaviorC rodentiumC. rodentiumCarbohydratesChronicCitrobacterCitrobacter freundii Biotype 4280Citrobacter rodentiumColitisD-GlucoseDataDefense MechanismsDextroseDiseaseDisorderEnteralEntericEvolutionFe elementGI microbiotaGastrointestinal microbiotaGlucoseGoalsHealthHost DefenseImmune responseImmunocompromisedImmunocompromised HostImmunocompromised PatientImmunologyImmunosuppressed HostIndividualInfectionInfection-induced colitisInfectious colitisInflammationIntermediary MetabolismIntestinalIntestinesInvestigationIronLeadLipidsMacronutrientsMacronutrients NutritionMediatingMetabolicMetabolic ControlMetabolic ProcessesMetabolismMiceMice MammalsMicrobeMicronutrientsModelingMucosaMucosal TissueMucous MembraneMurineMusOutcomePathogenicityPathologyPathway interactionsPb elementPhenotypePhysiologicPhysiologicalPhysiologyProcessRegulationResearchRoleStarvationSymbiosisSystemTransmissionVirulenceVirulentWorkacquired immune systemadaptive immune responseattenuateattenuatesattenuationbacteria pathogenbacterial pathogenbowelcarbohydrate metabolismcommensalismcommunity microbesdietaryenteral pathogenenteric microbial communityenteric microbiotaenteric pathogenenteropathogenfat metabolismfitnessgastrointestinalgastrointestinal microbial floraglucose metabolismgut communitygut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiotagut microbioticgut microfloraheavy metal Pbheavy metal leadhost microbiotahost microflorahost responseimmune system responseimmunoresponseimmunosuppressed patientin vivointestinal floraintestinal microbiotaintestinal microfloraintestinal pathogenintestinal tract microfloraintestine pathogenlipid metabolismmembermicrobe communitymicrobe pathogenmicrobialmicrobial communitymicrobial consortiamicrobial floramicrobial pathogenmicrobiotamicrofloramicroorganism communitymouse modelmultispecies consortiamurine modelnovelpathogenpathogenic bacteriapathogenic microbepathwaypolymicrobial communitypreventpreventingprogramspsychological defense mechanismresident microbesresident microfloraresponsesocial rolesynergismtooltransmission process

Applications closed.

Description preview

Project Summary
The overall goal of this proposal is to understand how host metabolic adaptations during infection promote co-
operative defenses between a host and enteric pathogens to drive asymptomatic carriage and the eventual
evolution of commensalism. The proposed studies utilize a natural in vivo host-pathogen involving a enteric
bacterial…

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