grant
TNFRSF13B polymorphisms and immunity to transplantation
Organization CASE WESTERN RESERVE UNIVERSITYLocation CLEVELAND, UNITED STATESPosted 15 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY20255' Untranslated Regions5'UTRAb responseAcuteAddressAffinityAllelesAllelomorphsAlloantibodiesAlloantigenAntibodiesAntibody FormationAntibody ProductionAntibody ResponseAntigensAntimorphic mutationAvidityB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBasal Transcription FactorBasal transcription factor genesBindingBiopsyBlood SerumCSIFCSIF-10CardiacCardiac TransplantationCell BodyCell CoatCell FunctionCell IsolationCell PhysiologyCell ProcessCell SegregationCell SeparationCell Separation TechnologyCellsCellular FunctionCellular PhysiologyCellular ProcessCharacteristicsChronicClinicalClonal ExpansionClone CellsCognitive DiscriminationComplementComplement ActivationComplement Factor HComplement Factor PComplement ProteinsCytokine Synthesis Inhibitory FactorDNA mutationDevelopmentDisablingDiscriminationDominant NegativeDominant-Negative MutantDominant-Negative MutationEngineeringEnrollmentEquilibriumEvolutionFactor HFrequenciesGene ExpressionGene SplicingGeneHomologGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic ChangeGenetic PolymorphismGenetic defectGenetic mutationGenomicsGenotypeGerm LinesGlycocalyxGrafting ProcedureHealthHeart GraftingHeart TransplantationHomologHomologous GeneHomologueHumanIL-10IL10IL10AImmuneImmune responseImmunesImmunityInjuryInterleukin 10 PrecursorInterleukin-10InvestigationInvestigatorsIsoantibodiesKO miceKidney GraftingKidney TransplantationKidney TransplantsKineticsKnock-out MiceKnockout MiceMammaliaMammalsMediatingMiceMice MammalsMichiganModern ManMolecular InteractionMurineMusMutateMutationNational Institutes of HealthNull MouseOrgan TransplantationOrgan TransplantsOutcomePathogenicityPathologyPhenotypePopulationProbabilityProductionProperdinPropertyPublicationsReceptor ProteinRenal GraftingRenal TransplantationRenal TransplantsResearchResearch PersonnelResearchersResistanceRiskRoleSamplingScientific PublicationSerumShapesSpecificitySpliced GenesSubcellular ProcessTestingTimeTissue GraftsTranscriptTranscription Factor Proto-OncogeneTranscription factor genesTransplant RecipientsTransplantationUnited States National Institutes of HealthVariantVariationWild Type Mousealloimmunityallotransplantallotransplantationantibody biosynthesisantibody rejectionantibody-mediated rejectionbalancebalance functioncardiac allograftcardiac graftcell sortingcohortcomplement pathway regulationcomplementationdevelopmentaldonor antibodiesdonor-specific antibodyenrollexperiencefactor Pgenetic analysisgenome mutationgraft functionheart allograftheart transplanthost responseimmune system responseimmunogenimmunoglobulin biosynthesisimmunoresponseinjuriesisoimmunitykidney txmRNA Leader Sequencesnatural antibodiesnon-synonymous mutationnonsynonymous mutationnonsynonymous single nucleotide polymorphismnonsynonymous single nucleotide variantnonsynonymous single-nucleotide substitutionnonsynonymous variantorgan allograftorgan graftorgan xenograftpathogenplasma cell differentiationpolymorphismreceptorresistantresponsesocial roletissue graftingtraittranscription factortransplanttransplant patientwildtype mouse
Description preview
Abstract:
The proposed research investigates how genomic polymorphism of the TNFRSF13B
locus predicts and potentially governs the immune response to and outcomes of
transplantation. The investigators (de Mattos Barbosa et al., 2021) recently found that
non-synonymous mutations of TNFRSF13B occur 5-fold more frequently in kidney
transplant…
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