grant
TNF in Injury and Repair Processes Following Traumatic SCI
Organization GEORGE WASHINGTON UNIVERSITYLocation WASHINGTON, UNITED STATESPosted 1 Apr 2005Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2025(TNF)-αAgeAgonistAmmon HornAnteriorAttenuatedBrain regionCD 120a AntigenCD 120b AntigenCD120a AntigensCD120b AntigensCachectinCachectin ReceptorsCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell SignalingCell-to-Cell InteractionCellsCombined Modality TherapyCornu AmmonisDataDevelopmentDifferences between sexesDiffers between sexesDiseaseDisorderER-BETAERbetaERβESR-BETAESR2ESR2 geneESRBESTRBElderlyEstrogen Receptor 2Estrogen Receptor betaEstrogen Receptor βEstrogen ReceptorsEstrogen ReplacementsEstrogensFaslodexFemaleFulvestrantGeneticGenetic studyGoalsHealth CareHippocampusICI 182,780ICI 182780ImmuneImmunesIndividualInflammationIntracellular Communication and SignalingMacrophage-Derived TNFMediatorMiceMice MammalsModelingMonocyte-Derived TNFMultimodal TherapyMultimodal TreatmentMurineMusNADPH dependent FMN and FAD containing oxidoreductaseNADPH dependent diflavin oxidoreductase 1NADPH-Dependent FMN and FAD Containing OxidoreductaseNDOR1NR1NR1 geneNR3A2Nerve CellsNerve UnitNeural CellNeurocyteNeuronsOophorectomyOvariectomyPainPainfulPathologicPathologic ProcessesPathological ProcessesPeripheral nerve injuryProcessPublishingReceptor ProteinReceptor SignalingReceptors, Tumor Necrosis Factor, Type IIRecoveryResolutionRoleSeriesSex DifferencesSexual differencesSignal TransductionSignal Transduction SystemsSignalingSomatosensory CortexSpinal Cord TraumaSpinal TraumaSpinal cord injuredSpinal cord injurySynapsesSynapticTNFTNF ATNF AlphaTNF Receptor Family ProteinTNF Receptor SuperfamilyTNF Receptor p55TNF ReceptorsTNF geneTNF-R2TNF-RIITNF-sR55TNF-αTNF-α receptorTNFATNFARTNFBRTNFRTNFR p60TNFR p75TNFR, 55-kDTNFR, 60-kDTNFR-ITNFR1TNFR2TNFR55TNFR60TNFR80TNFRSF1ATNFRSF1A ReceptorTNFRSF1A geneTNFRSF1BTNFRSF1B ReceptorTNFRSF1B geneTNFalpha receptorTNFαTNFα receptorTestingTherapeuticTherapeutic EstrogenTraumatic MyelopathyTumor Necrosis FactorTumor Necrosis Factor Beta ReceptorTumor Necrosis Factor ReceptorTumor Necrosis Factor Receptor 1Tumor Necrosis Factor Receptor 2Tumor Necrosis Factor Receptor 55Tumor Necrosis Factor Receptor 75Tumor Necrosis Factor Receptor FamilyTumor Necrosis Factor Receptor SuperfamilyTumor Necrosis Factor Receptor Type 2Tumor Necrosis Factor-alphaUnited StatesWomanadvanced ageagesattenuateattenuatesbiological signal transductionchronic neuropathic painchronic painchronic pain controlchronic pain interventionchronic pain managementchronic pain therapychronic pain treatmentcingulate cortexcombination therapycombined modality treatmentcombined treatmentdesigndesigningdevelop therapydevelopmentaleffective therapyeffective treatmentfemale gonadectomygenetic approachgenetic strategygeriatrichippocampalinhibitorinjury and repairintervention developmentmalemenmulti-modal therapymulti-modal treatmentneural inflammationneuroinflammationneuroinflammatoryneuronalneuropathologicneuropathologicalneuropathologynew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyperipheral nerve crush injuriespharmacologicpreventpreventingreceptorresolutionssenior citizensexsex based differencessex-dependent differencessex-related differencessex-specific differencessocial rolesomatosensorysomesthetic sensory cortexsynapsetherapy developmenttreat chronic paintreatment developmenttumor necrosis factor alpha receptortumor necrosis factor receptor 1Atumor necrosis factor receptor superfamily, member 1Btumor necrosis factor α receptor♀♂
Description preview
Abstract
Chronic neuropathic pain (CNP) is a maladaptive pathological process that is poorly understood and a condition
for which no effective therapies exist. It is largely recognized that neuroinflammation significantly contributes to
the development of chronic pain, however the mechanisms are not well understood. A unifying mechanism
through…
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