grant
TMJ Disc Regeneration
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 8 Aug 2024Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY20253 year old3 years of ageAbscissionAddressAdolescentAdolescent YouthAllograftingAnatomic SitesAnatomic structuresAnatomyAnimalsAnteriorArthritisArticulationAutograftAutologous TransplantationAutotransplantBiochemistryBiologicalBiological ChemistryBody TissuesCaprine SpeciesCausalityCell-Extracellular MatrixChewingClinicalComplexCoriumCutisDermisDevelopmentECMEffectivenessEnvironmentEtiologyExcisionExhibitsExtirpationExtracellular MatrixFDA approvedFaceFamily suidaeFatsFatty acid glycerol estersFemaleFibrocartilagesGeneralized GrowthGenerationsGoalsGoatGoats MammalsGrowthHistologyHourHumanImplantInflammationJaw JointJointsMandibular jointMasticationMechanicsModelingModern ManMotionOperative ProceduresOperative Surgical ProceduresOutcomePathogenicityPathologicPathologyPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPigsPropertyRemovalReplacement TherapyResearchRotationSecureSmall Intestinal SubmucosaStructureStructure of articular disc of temporomandibular jointStudy modelsSuidaeSurfaceSurgicalSurgical InterventionsSurgical ManagementSurgical ProcedureSurgical RemovalSwineTMJTMJ DiscTechnologyTemporomandibular Articular DiskTemporomandibular JointTemporomandibular Joint DiskTestingTimeTissue GrowthTissuesTranslationsWorkZygomatic Archadult animalage 3 yearsarthriticautologous graftautotransplantationbiologicbonecanine animal modelcanine modelcausationchewedchewsclinical relevanceclinical translationclinically relevantclinically translatabledevelopmentaldisc regenerationdisease causationdog modelfacesfacialfat graftingfibrocartilaginousfunctional outcomesimplantationimproved outcomein vivojoint damagejoint injuryjoint traumajuvenilejuvenile humanmalemature animalmechanicmechanicalmigrationontogenypatient oriented outcomespig modelpiglet modelporcineporcine modelpreventpreventingregenerate disc tissueregenerate new tissueregenerate tissueregenerating damaged tissueregenerating tissueresectionscaffoldscaffoldingskeletalsuidsurgeryswine modeltherapeutically effectivethree year oldthree years of agetissue regenerationtissue regrowthtissue renewaltissue specific regenerationtranslation♀♂
Description preview
Patients opting for TMJ disc removal face issues due to the absence of FDA-approved
replacements, leading to bone-to-bone contact and subsequent joint problems. Autografts, like
dermis-fat grafts, typically resorb within a year. Our goal is a secure disc replacement
alternative. Previous studies demonstrated rapid transformation of an acellular…
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