grant
Tissue Perfusion Pressure for Improved Management of Circulatory Shock
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 1 Jul 2024Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AdmissionAdmission activityAnimal ExperimentsAnimal ModelAnimal Models and Related StudiesArteriesAutomobile DrivingBedsBleedingBlood PressureBlood Pressure MonitorsBlood flowBody TissuesCardiac OutputCardiac SurgeryCardiac Surgery proceduresCardiogenic ShockCell Communication and SignalingCell SignalingCessation of lifeCirculationCirculatory CollapseClinicalClinical ManagementClinical TrialsComputational TechniqueConsensusContinuous SphygmomanometersConvNetCritical CareCritical IllnessCritically IllDataData BasesData CollectionDatabasesDeathDiagnosisDiseaseDisorderDropsDrugsElectric Convulsive TherapyElectric Shock TherapyElectroconvulsive PsychotherapyElectroconvulsive Shock TherapyElectroconvulsive TherapyElectroconvulsive treatmentElectronicsElectroshock PsychotherapyElectroshock TherapyElectroshock treatmentElementsFeedbackFoundationsFutureGeneral HospitalsGoalsGraphical interfaceHeart Surgical ProceduresHeart failureHemorrhageHemorrhagic ShockImageIndividualInfectionIntensive Care UnitsInterventionIntracellular Communication and SignalingLabelLifeLight Reflection RheographyLiquid substanceMassachusettsMeasuresMedicationMedicineMethodsModelingNatureOrganOrgan ModelPatientsPatternPerfusionPharmaceutical PreparationsPhenotypePhotoplethysmographyPhotoreflexometriesPhotoreflexometryPhysiologicPhysiologic MonitoringPhysiologicalPhysiological MonitoringPhysiologyPredicting RiskPropertyResuscitationSepsisSeveritiesShockSignal TransductionSignal Transduction SystemsSignalingTestingTherapeuticTherapeutic InterventionTimeTissuesTitrationsTrainingVasoactive AgonistsVasoconstrictor AgentsVasoconstrictor DrugsVasoconstrictorsVasopressor Agentsanimal dataanimal experimentapplied learningbiological signal transductionblood losscardiac failurecardiac shockcirculatory shockclinical careclinical databaseclinical decision supportclinical decision-makingclinical diagnosisclinical practiceco-morbidco-morbiditycohortcomorbiditycomputational pipelinesconvolutional networkconvolutional neural netsconvolutional neural networkdata basedesigndesigningdrivingdrug/agentelectric shock treatmentelectro-convulsive therapyelectronicelectronic deviceelectroplexy shock therapyexperimental animalexperimental animalsfluidforecasting riskgraphic user interfacegraphical user interfacehands-on learningheart outputheart surgeryhemodynamicsimagingimprovedinjury to organsinteractive engagementinteractive learningintervention therapyliquidmodel of animalmortalitynew approachesnovelnovel approachesnovel strategiesnovel strategyorgan injurypatient populationpcritpharyngeal critical pressurepig modelpiglet modelporcine modelpre-clinicalpre-clinical studypreclinicalpreclinical studypredict riskpredict riskspredicted riskpredicted riskspredicting riskspredictive riskpredicts riskpressurepreventpreventingprospectiverandomized, clinical trialsresponserisk predictionrisk predictionsshock treatmentshockssoftware user interfacestandard of caresupport toolsswine modeltargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttheoriestherapeutic targettransfer learningtreatment guidelinestrial designvascular bedvasopressor
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Description preview
Circulatory shock is one of the most common reasons for admission to an intensive care unit (ICU) and results
from inadequate blood pressure and blood flow to support organ function. Causes of circulatory shock include
heart failure, sepsis, and hemorrhage. Prompt treatment is required to restore adequate blood pressure to
prevent severe organ…
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