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Tissue-engineered regeneration of the minipig TMJ condyle
Organization UNIVERSITY OF CALIFORNIA-IRVINELocation IRVINE, UNITED STATESPosted 11 Apr 2023Deadline 10 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult HumanAffectAgeAmericanAnimal ModelAnimal Models and Related StudiesAnimalsArthralgiaAssayBenchmarkingBest Practice AnalysisBioassayBiochemicalBiochemistryBiological AssayBiological ChemistryBiological MimeticsBiomechanicsBiomimeticsBody TissuesBone Morphogenetic Protein GeneBone Morphogenetic ProteinsBone marrow-derived mesenchymal stem cellsCalcifiedCartilageCartilage MatrixCartilaginous TissueClinicClinicalClinical TrialsCollagen Type ICollagen Type IICollagen Type XDataDefectDegenerative ArthritisDegenerative polyarthritisEngineeringFacultyFailureFibrocartilagesFinancial SupportFundingGlycerolphosphatesGlycerophosphatesGoalsGoldHistologicHistologicallyHistologyHumanHyaline CartilageImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImplantInterventionJaw JointJoint PainL-TriiodothyronineLifeLiothyronineLiquid substanceMALD-MSMALDIMALDI-MSMandibular CondyleMandibular jointMapsMechanicsMentorsMesenchymal Progenitor CellMesenchymal Stem CellsMesenchymal progenitorMesenchymal stromal/stem cellsMethodologyMethodsMiniature SwineMinipigsModelingModern ManMorphologyNatural regenerationOperative ProceduresOperative Surgical ProceduresOsteoarthritisOsteoarthrosisPatientsPhasePopulationPositionPositioning AttributePostdocPostdoctoral FellowProcessPropertyProteomicsRegenerationReportingResearchResearch AssociateSafetySpatial DistributionSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationSpectroscopy, Mass, Matrix-Assisted Laser Desorption-IonizationStructure of articular disc of temporomandibular jointSurgicalSurgical InterventionsSurgical ProcedureT-3T3 Thyroid HormoneTMJTMJ DiscTMJ DiseasesTMJ DisordersTMJDTechniquesTemporomandibular Articular DiskTemporomandibular DisordersTemporomandibular JointTemporomandibular Joint DiseasesTemporomandibular Joint DiskTemporomandibular Joint DisordersTemporomandibular Joint and Muscle DisorderTensile StrengthTherapeutic T3Therapeutic TriiodothyronineTimeTissue EngineeringTissuesTrainingTranslationsTriiodothyronineType 1 CollagenUniversitiesadulthoodagesanalogarticular cartilagebenchmarkbioengineered tissuebiomechanicalbonebone marrow mesenchymal progenitorbone marrow mesenchymal stem cellbone morphogenic proteinbone scaffoldcalcificationcartilage implantcartilage regenerationcondylar cartilagedegenerative joint diseasedesigndesigningengineered tissueexperimentexperimental researchexperimental studyexperimentsfibrocartilaginousfinancial assistancefluidglycerophosphatehypertrophic arthritisimaging mass spectrometryimprovedin vivoin vivo Modelinterfacialliquidmass spectrometric imagingmatrix assisted laser desorption ionizationmechanicmechanicalmechanical propertiesmechanical stimulusmesenchymal stromal cellmesenchymal stromal progenitor cellsmesenchymal-derived stem cellsmini pigmini-swineminiswinemodel of animalnovelosteochondralosteochondral tissuepost-docpost-doctoralpost-doctoral traineepre-clinicalpreclinicalpreventpreventingregenerateregenerate new tissueregenerate tissueregenerating damaged tissueregenerating tissueresearch associatesself assemblysuccesssurgerytissue regenerationtissue regrowthtissue renewaltissue specific regenerationtooltranslation
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Project Summary
Approximately 10-25% of the population has degeneration of the temporomandibular joint (TMJ) condyle.
Cartilage does not heal itself, and there are no mid-stage interventions to prevent condylar degeneration which
can lead to life-threatening conditions such as changes to the airway. This proposal aims to improve translation
of…
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