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Tissue elasticity and viscosity modulates macrophage-fibroblast signaling in cardiac fibrosis

Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 1 Apr 2025Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY2025AcuteAdhesion MoleculeAffectAortic AneurysmBiochemicalBiophysicsBody TissuesCancersCardiacCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCell Adhesion Molecule GeneCell Adhesion MoleculesCell BodyCell CommunicationCell Communication and SignalingCell Culture SystemCell FunctionCell InteractionCell PhysiologyCell ProcessCell SignalingCell to Cell Communication and SignalingCell-Cell SignalingCell-Extracellular MatrixCell-to-Cell InteractionCellsCellular FunctionCellular MechanotransductionCellular PhysiologyCellular ProcessChronicCicatrixCo-cultureCocultivationCocultureCoculture TechniquesCommunicationComplexConnective Tissue DiseasesConnective Tissue DisorderCuesDNA mutationDevelopmentDiseaseDisorderECMElastic TissueElasticityEngineeringEnvironmentEthnic OriginEthnicityExtracellular MatrixExtracellular Matrix ProteinsFBN1FeedbackFibroblastsFibrosisFibrosis in the heartFibrosis in the myocardiumFibrosis within the heartFibrosis within the myocardiumFibrotic myocardiumGenesGenetic ChangeGenetic defectGenetic mutationHeartHeart VascularHeart failureHereditary DiseaseHourImmuneImmune infiltratesImmunesInborn Genetic DiseasesIndividualInflammationInflammatoryInflammatory ResponseInherited disorderInnate Immune SystemIntracellular Communication and SignalingMacrophageMacrophage ActivationMalignant NeoplasmsMalignant TumorMarfan SyndromeMechanical Signal TransductionMechanicsMechanosensory TransductionMediatingMethodsMolecularMolecular TargetMutationMφOutcome StudyOxidative StressPathologyPathway interactionsPhasePolystyrenesPolystyrolProductionProfibrotic factorProfibrotic signalRaceRacesRegulationRoleScarsSignal TransductionSignal Transduction SystemsSignalingStimulusSubcellular ProcessSurfaceTestingTissuesViscosityWorkautosomebiological signal transductionbiophysical foundationbiophysical principlesbiophysical sciencescardiac failurecardiac fibrosiscardiovascular disordercell adhesion proteincirculatory systemcoronary fibrosisdevelopmentalfibrillin-1fibrotic heartgenome mutationglobal healthhealingheart fibrosishereditary disorderheritable disorderimmune cell infiltratein vivoinborn errorinherited diseasesinherited genetic diseaseinherited genetic disorderinsightintercellular communicationmalignancymechanicmechanicalmechanical cuemechanical signalmechanical stimulusmechanosensingmechanotransductionmyocardial fibrosisneoplasm/cancernovelparacrinepathwayracialracial backgroundracial originrecruitresponsesocial rolespatial and temporalspatial temporalspatiotemporalsudden cardiac deathviscoelasticity

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Project Summary/Abstract
Cardiac fibrosis remains a global health problem that results from highly coordinated interactions between
macrophages, versatile cells of the innate immune system, and fibroblasts, cells responsible for extracellular
matrix production. Initial stages of fibrosis are characterized by an acute inflammatory response that…

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