grant
Thermodynamic and Functional Analysis of Consensus and Covariance in Proteins, and Bivalent Notch Complexes
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY2025AI basedAI systemAmino Acid SequenceAmino Acid Sequence DatabasesArtificial IntelligenceBindingBiologic SciencesBiologicalBiological SciencesBioscienceCell BodyCell Communication and SignalingCell DifferentiationCell Differentiation processCell SignalingCellsCommunitiesComplexComputer ReasoningComputing MethodologiesConsensusDNA mutationDiseaseDisorderGene TranscriptionGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationHLA-DR Associated Protein IIHumanIGAADIndustrializationInhibitor of GZMA-Activated DNaseIntracellular Communication and SignalingLeadLearning DisordersLife SciencesMachine IntelligenceMeasuresMethodsModern ManMolecularMolecular InteractionMutationNotch Signaling PathwayOutcomePb elementPhosphatase 2A Inhibitor I2PP2APositionPositioning AttributePrimary Protein StructureProtein EngineeringProtein Sequence DatabasesProteinsProteolysis and Signaling Pathway of NotchRNA ExpressionResearchRouteSET Translocation Inhibitor-2 of Protein Phosphatase-2ASet proteinSignal TransductionSignal Transduction SystemsSignalingStructureSwitching ComplexSystemTechniquesTemplate Activating Factor I BetaTestingTherapeuticThermodynamicThermodynamicsTimeTranscriptionWorkartificial intelligence basedbiologicbiological signal transductioncellular differentiationcomputational methodologycomputational methodscomputer based methodcomputer methodscomputing methoddesigndesigningdiagnostic toolfitnessgenetic protein engineeringgenome mutationheavy metal Pbheavy metal leadimprovedmolecular sequence databasenative protein drugnotchnotch proteinnotch receptorspharmaceutical proteinprotein designprotein drug agentprotein functionprotein sequenceprotein structureprotein structure predictionprotein structuresprotein-based drugproteins structureresilienceresilientsequence databasesequencing databasesuccesstherapeutic proteintool
Description preview
SUMMARY
It is an exciting time for research in molecular biosciences. The scientific community has
amassed a huge database of protein sequences and structures, and techniques to analyze their
structures and stabilities have undergone steady improvement. These advances have helped fuel a
revolution in computational methods, based on artificial…
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