grant
Therapeutics for the chorioretina
Organization NATIONAL EYE INSTITUTELocation UNITED STATES
NIHUS FederalResearch GrantFY2025APOEAccelerationAffinityAgeAge MonthsAgingAmino Acid SubstitutionAmino AcidsAmphoterinAmphoterin GeneAnimal ModelAnimal Models and Related StudiesApo-EApoE proteinApolipoprotein EAssayAutopsyB cell lymphoma 2B-Cell CLL/Lymphoma 2 GeneB-cell lymphoma/leukemia-2BAXBAX geneBCL2BCL2 geneBCL2-Associated X Protein GeneBCL2L4Bcl-2BindingBioassayBiological AssayBruch MembraneBruch's basal membrane structureBruch's membraneBruchs membraneC-terminalCell BodyCell DeathCellsCessation of lifeChromosomal Protein, Nonhistone, HMG1Chromosomal Protein, Nonhistone, HMG1 GeneCollaborationsComplement Factor HCryosectioningCryoultramicrotomyCytoplasmDNA mutationDeathDefectDental White SpotsDiseaseDisease ProgressionDisorderDomestic RabbitDrug TherapyDysfunctionEPC-1 proteinElectroretinographyEngineeringEpitheliumExhibitsEyeEye DropsEyeballEyedropsFM1 Gene ProductFactor HFunctional disorderGamma-H2AXGene ExpressionGenesGenetic ChangeGenetic defectGenetic mutationGoalsHMG-1HMG-1 GeneHMG-1 ProteinHMG1HMG1 GeneHMG3HMG3 GeneHMGB1HMGB1 ProteinHMGB1 geneHealthHeparin-Binding Protein p30HereditaryHigh Mobility Group Box Protein 1High Mobility Group Protein 1High Mobility Group Protein 1 GeneHigh-Mobility Group (Nonhistone Chromosomal) Protein 1High-Mobility Group (Nonhistone Chromosomal) Protein 1 GeneHigh-Mobility Group Box 1High-Mobility Group Box 1 GeneHistologicHistologicallyHistologyHumanImageImmunofluorescenceImmunofluorescence ImmunologicIndividualInflammatoryInheritedInterventionIntervention StudiesLamina Basalis ChoroideaeLecithinasesLengthLipidsMembraneMesenchymalMiceMice MammalsModelingModern ManModificationMolecularMolecular InteractionMonitorMorphologyMurineMusMutationNatural HistoryNonhistone Chromosomal Protein HGM1Nonhistone Chromosomal Protein HGM1 GeneNuclearOccluding JunctionsOperative ProceduresOperative Surgical ProceduresOrganoidsOryctolagus cuniculusOxidative Stress InductionPEDFPEDF receptorPathologyPathway interactionsPatientsPeptidesPharmacological TreatmentPharmacotherapyPhosphatidesPhosphatidylserinesPhosphodiesterasesPhospholipasePhospholipidsPhotoreceptor CellPhotoreceptorsPhotosensitive CellPhysiopathologyPigment EpitheliumPigmentary RetinopathyRNA SeqRNA sequencingRNAseqRabbitsRabbits MammalsReceptor ProteinRetinaRetinal DegenerationRetinal DiseasesRetinal DisorderRetinitis PigmentosaRhodopsinRoleSBP-1SBP-1 GeneSerine PhosphoglyceridesSerpinsSightStaining methodStainsStructureSulfoglucuronyl Carbohydrate Binding ProteinSulfoglucuronyl Carbohydrate Binding Protein GeneSurgicalSurgical InterventionsSurgical ProcedureTapetoretinal DegenerationTestingTherapeuticThickThicknessTight JunctionsTimeVisionVisual PurpleVisual ReceptorWhite SpotsWorkWound RepairZincZn elementZonula Occludensagesaminoacidattenuationbcl-2 Genesbeta-D-Galactosidasebeta-D-Galactoside galactohydrolasebeta-Galactosidaseced9 homologcigarette smoke exposuredegenerative retina diseasesdetermine efficacydiagnostic assaydiagnostic tooldrug interventiondrug treatmentearly PDL proteinearly population doubling level cDNA-1 proteinearly population doubling level proteineffective therapyeffective treatmentefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationelectroretinogramevaluate efficacyexamine efficacyexposure to cigarette smokeextracellularfundus imaginggenome mutationhiPSChuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellshuman modelhuman tissueiPSiPSCiPSCsimagingimmunocytochemistryimprovedin vivoin vivo Modelinduced human pluripotent stem cellsinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinhibitorintervention researchinterventional researchinterventional studyinterventions researchlac Z Proteinmatrigelmembrane structuremigrationminimally invasivemodel of animalmodel of humanmouse modelmurine modelnecrocytosisnecropsynew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathophysiologypathwaypeptide chemical synthesispharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsphosphoric diester hydrolasepigment epithelium-derived factorpigment epithelium-derived factor receptorpostmortempreventpreventingprotective effectprotein chemical synthesisreceptorretina degenerationretina diseaseretina disorderretinal degenerativeretinal degenerative diseasesretinopathyrod and cone dystrophyrod-cone dystrophysenescencesenescentsocial rolesurgerytherapeutic agent developmenttherapeutic developmenttranscriptome sequencingtranscriptomic sequencingtranslational opportunitiestranslational potentialvectorvisual functionwound healingwound recoverywound resolutionβ-D-Galactosidaseβ-D-Galactoside galactohydrolaseβ-GalactosidaseγH2AX
Description preview
We completed work demonstrating that deletion of Pnpla2 (PEDF-R) causes structural and functional defects in mouse photoreceptors. We also finalized a study on H105A peptide eye drops that promoted photoreceptor survival in murine and human models of retinal degeneration. Photoreceptor death underlies inherited blinding retinal diseases such as…
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