grant
Therapeutic targeting the host hypoxia-response pathway to treat Mucormycosis
Organization UNIVERSITY OF MARYLAND BALTIMORELocation BALTIMORE, UNITED STATESPosted 25 Mar 2025Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY2025ANGPTL4ANGPTL4 geneAbbreviationsAbscissionAcidosisAdrenal Cortex HormonesAdverse effectsAfghanistanAmBAmBisomeAmphocilAmphotecAmphotercin BAmphotericin BAngiopoietin-Like 4Animal ModelAnimal Models and Related StudiesAnti-Infective AgentsAnti-Infective DrugsAnti-InfectivesAnti-infective PreparationAntifungal TherapyAttenuatedBasal Transcription FactorBasal transcription factor genesBindingBlood DiseasesBody TissuesBone Marrow GraftingBone Marrow TransplantBone Marrow TransplantationBurn injuryBurnsCOVID crisisCOVID epidemicCOVID infected patientCOVID pandemicCOVID patientCOVID positive patientCOVID-19 crisisCOVID-19 epidemicCOVID-19 eraCOVID-19 global health crisisCOVID-19 global pandemicCOVID-19 health crisisCOVID-19 infected patientCOVID-19 pandemicCOVID-19 patientCOVID-19 periodCOVID-19 positive patientCOVID-19 public health crisisCOVID-19 yearsCOVID19 patientCOVID19 positive patientCaringCell AnoxiaCell HypoxiaCellular AnoxiaCellular HypoxiaCerebrumClassificationClinicalCorticoidsCorticosteroidsDataDeath RateDebridementDeferoxamineDeferoxamine BDeferoximineDeferrioxamine BDesferioximineDesferrioxamineDesferrioxamine BDesferroxamineDevelopmentDiabetes MellitusDiabetic AcidosisDiabetic KetoacidosisDiabetic KetosisDiseaseDisease ProgressionDisorderDoseDrug TherapyEGF ReceptorEGFRERBB ProteinEndothelial CellsEpidermal Growth Factor ReceptorEpidermal Growth Factor Receptor KinaseEpidermal Growth Factor Receptor Protein-Tyrosine KinaseEpidermal Growth Factor-Urogastrone ReceptorsEpithelial CellsEpitheliumExcisionExtirpationEyeEyeballFIAFFasting-Induced Adipose FactorFilamentous FungiFungizoneFungus DiseasesGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic TechnicsGenetic TechniquesGenetic TranscriptionGenomicsGoalsHER1HFARPHIF 1 alphaHIF-1alphaHIF1-AlphaHIF1AHIF1A geneHIF1αHematologic DiseasesHematological DiseaseHematological DisorderHepatic Fibrinogen/Angiopoietin-Related ProteinHyperbaric O2Hyperbaric OxygenHyperglycemiaHypoxiaHypoxia Inducible FactorHypoxicIn VitroInfectionInhalationInhalingInnate Immune ResponseIntegrinsIntegrins Extracellular MatrixInvadedIraqLungLung Respiratory SystemMOP1MalignantMalignant - descriptorMarrow TransplantationModalityMoldsMolecularMolecular InteractionMorbidityMorbidity - disease rateMucoralesMucormycosisMycosesMysteclin-FNIAIDNational Institute of Allergy and Infectious DiseaseNatureNephrotoxicNeutropeniaOperative ProceduresOperative Surgical ProceduresOrganOxygen DeficiencyPGARPPARG Angiopoietin-Related ProteinPathogenesisPathway interactionsPatientsPharmacological TreatmentPharmacotherapyPlayPredispositionPrevalenceProcessProtein SecretionProteinsPublishingRNA ExpressionRNA SeqRNA sequencingRNAseqReceptor CellRemovalReportingReproduction sporesResearchRespiratory EpitheliumRhizopusRisk FactorsRoleSARS-CoV-2 epidemicSARS-CoV-2 global health crisisSARS-CoV-2 global pandemicSARS-CoV-2 infected patientSARS-CoV-2 pandemicSARS-CoV-2 patientSARS-CoV-2 positive patientSARS-coronavirus-2 epidemicSARS-coronavirus-2 pandemicSalvage TherapySalvage-TxSevere Acute Respiratory Syndrome CoV 2 epidemicSevere Acute Respiratory Syndrome CoV 2 pandemicSevere acute respiratory syndrome coronavirus 2 epidemicSevere acute respiratory syndrome coronavirus 2 pandemicSolidSporesStructure of respiratory epitheliumSurgicalSurgical InterventionsSurgical ProcedureSurgical RemovalSusceptibilitySystematicsTGF-alpha ReceptorTestingTherapeuticTherapeutic FungicidesTissuesTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransforming Growth Factor alpha ReceptorTraumaUrogastrone ReceptorVaccinesVascular PermeabilitiesViral DiseasesVirulenceVirus DiseasesWorkWorld Health OrganizationZygomycosisairway epitheliumanti-fungalanti-fungal agentsanti-fungal drugassess effectivenessattenuateattenuatesblood disorderburnedc-erbB-1c-erbB-1 Proteincerebralclinical relevanceclinically relevantcommunicable disease control agentcoronavirus disease 2019 crisiscoronavirus disease 2019 epidemiccoronavirus disease 2019 global health crisiscoronavirus disease 2019 global pandemiccoronavirus disease 2019 health crisiscoronavirus disease 2019 infected patientcoronavirus disease 2019 pandemiccoronavirus disease 2019 patientcoronavirus disease 2019 positive patientcoronavirus disease 2019 public health crisiscoronavirus disease crisiscoronavirus disease epidemiccoronavirus disease infected patientcoronavirus disease pandemiccoronavirus disease patientcoronavirus disease positive patientcoronavirus disease-19 global pandemiccoronavirus disease-19 pandemiccoronavirus disease-19 patientcoronavirus patientdetermine effectivenessdetermine efficacydevelopmentaldiabetesdiabetic ketoacidoticdrug interventiondrug treatmenteffectiveness assessmenteffectiveness evaluationefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationerbB-1erbB-1 Proto-Oncogene ProteinerbBlevaluate effectivenessevaluate efficacyexamine effectivenessexamine efficacyfungal infectionfungal infectious disease treatmentfungusfungus infectionhyperglycemicimprovedin vivoinjured soldierinjured warriorkidney toxicityleukemiamodel of animalmortalitymortality ratemortality ratiomouse modelmurine modelnephrotoxicitynew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathwaypatient infected with COVIDpatient infected with COVID-19patient infected with SARS-CoV-2patient infected with coronavirus diseasepatient infected with coronavirus disease 2019patient infected with severe acute respiratory syndrome coronavirus 2patient with COVIDpatient with COVID-19patient with COVID19patient with SARS-CoV-2patient with coronavirus diseasepatient with coronavirus disease 2019patient with severe acute respiratory distress syndrome coronavirus 2pharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsposaconazolepreventpreventingproto-oncogene protein c-erbB-1pulmonaryresectionrespiratory tract epitheliumresponsescRNA sequencingscRNA-seqsevere acute respiratory syndrome coronavirus 2 global health crisissevere acute respiratory syndrome coronavirus 2 global pandemicsevere acute respiratory syndrome coronavirus 2 infected patientsevere acute respiratory syndrome coronavirus 2 patientsevere acute respiratory syndrome coronavirus 2 positive patientsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesuccesssurgerytherapeutic targettranscription factortranscriptome sequencingtranscriptomic sequencingviral infectionvirus infectionvirus-induced diseasewounded soldierwounded warrior
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PROJECT SUMMARY/ABSTRACT
Mucormycosis is a deadly invasive infection caused by several fungal species belonging to the order
Mucorales. The major risk factors include uncontrolled diabetes mellitus that results in hyperglycemia and
ketoacidosis (DKA), other forms of acidosis, treatment with corticosteroids, solid organ or bone marrow…
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