grant
Therapeutic Targeting of Upregulated BAP1 in Human Hepatocellular Carcinoma
Organization UNIVERSITY OF HAWAII AT MANOALocation HONOLULU, UNITED STATESPosted 1 May 2026Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026AblationAddressAllelic LossBAP1 geneBRCA1 Associated Protein-1BRCA1-Associated Protein 1CRISPRCRISPR/Cas systemCancer CauseCancer CenterCancer EtiologyCancersCarcinoma CellCausalityCellular ExpansionCellular GrowthCerebral Protein-13Cerebral Protein-6Cessation of lifeCholesterol HomeostasisClustered Regularly Interspaced Short Palindromic RepeatsDNA mutationDataData BasesDatabasesDeathDiagnosisEthnic OriginEthnicityEtiologyFunding MechanismsGenesGenetic ChangeGenetic defectGenetic mutationGerm LinesHCC cellHCC cell lineHawaiiHepatic CancerHepatocarcinomaHepatocarcinoma modelHepatocellular CarcinomaHepatocellular cancerHepatomaHumanImmune mediated therapyImmunologically Directed TherapyImmunotherapyKO miceKnock-out MiceKnockout MiceLiver Cells CarcinomaLoss of HeterozygosityMalignant Epithelial CellMalignant NeoplasmsMalignant TumorMalignant neoplasm of liverMessenger RNAMiceMice MammalsModern ManMurineMusMutationNull MouseOncogenicPathogenesisPathologyPathway interactionsPatientsPatternPlasmidsPre-Clinical ModelPreclinical ModelsPrimary Malignant Neoplasm of LiverPrimary carcinoma of the liver cellsPrimary liver cancerRNA SeqRNA sequencingRNAseqResearch SpecimenRiskRoleSamplingSolidSpecimenStaining methodStainsSurvival RateSymptomsSyndromeTestingTherapeuticTreatment EfficacyTumor Suppressor ProteinsUniversitiesc mycc-myc Genescausationcell growthcholesterol biosynthesischolesterol metabolismcmycdata basedetermine efficacydisease causationeffective therapyeffective treatmentefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationevaluate efficacyexamine efficacygenome mutationhepatocellular carcinoma cancer modelhepatocellular carcinoma cell linehepatocellular carcinoma modelimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyinhibitorinnovateinnovationinnovativeintervention efficacyliver cancerliver cancer modelliver carcinomaliver developmentliver malignancyloss of functionloss of function mutationmRNAmalignancymalignant liver tumorneoplasm/cancernovelpathwayprotein expressionsocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic efficacytherapeutic targettherapy efficacytranscriptome sequencingtranscriptomic sequencingtumortumor suppressorv-myc Avian Myelocytomatosis Viral Oncogene Cellular Homolog
Description preview
Abstract
Hepatocellular carcinoma (HCC), commonly known as liver cancer, is one of the leading causes of cancer-
related death worldwide. Due to its lack of specific symptoms, HCC is frequently diagnosed at the advanced
stage, when the treatment options are quite limited. Currently, immunotherapy is the first line treatment option
for advanced…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click