grant
Therapeutic Targeting of Transcription-Driven Epigenetic Defects in SF3B1 Mutant Myelodysplastic syndromes (MDS)
NIHUS FederalResearch GrantFY202521+ years old3-D3-Dimensional3DAccountingAcuteAddressAdultAdult HumanAdvisory CommitteesAffectAlternate SplicingAlternative RNA SplicingAlternative SplicingAnemiaArchitectureBindingBiochemicalBiologyBleedingBlood CellsBlood DiseasesBone MarrowBone Marrow Reticuloendothelial SystemBone marrow failureCancer GenesCancer-Promoting GeneCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesChromatinChromatin StructureClinicalClonal EvolutionComplementComplement ProteinsComplexDNA mutationDataData SetDefectDevelopmentDevelopment PlansDiseaseDisorderDysmyelopoietic SyndromesEngineering / ArchitectureEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExpression SignatureGene ExpressionGene Expression ProfileGene TranscriptionGenesGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenomeGlobal ChangeHDACHDAC ProteinsHDAC2HDAC2 geneHematologic DiseasesHematological DiseaseHematological DisorderHematopoiesisHematopoietic Cellular Control MechanismsHemorrhageHigher Order Chromatin FoldingHigher Order Chromatin StructureHigher Order StructureHistone DeacetylaseHistonesImpairmentInduced DNA AlterationInduced MutationInduced Sequence AlterationInfectionInvestigationIsoformsK-AwardsK-Series Research Career ProgramsKineticsKnowledgeLinkMentorsMentorshipMetabolic Protein DegradationModelingModificationMolecularMolecular InteractionMutationMyelodysplastic DiseaseMyelodysplastic SyndromesNon-Polyadenylated RNANuclearOncogenesP-TEFbPDX modelPathogenesisPathway interactionsPatient derived xenograftPatientsPeripheral Blood CellPhysiciansPolymerasePositive Transcription Elongation Factor BPositive Transcriptional Elongation Factor BPre-mRNAPrincipal InvestigatorProcessProtein IsoformsProtein TurnoverProteinsRNARNA ExpressionRNA Gene ProductsRNA SplicingRNA, Messenger, PrecursorsRecurrenceRecurrentRefractory Anemia with an Excess of BlastsRefractory anaemia with excess blastsRegulationRegulator GenesRegulatory Protein DegradationResearchResearch Career ProgramReverse TranscriptionRibonucleic AcidRoleSC35SRSF2SRSF2 geneSamplingScientistSerine/Arginine-Rich Splicing Factor 2ShapesSmoldering LeukemiaSpliceosome AssemblySpliceosome Assembly PathwaySpliceosomesSplicingSystemTask ForcesTestingTherapeuticTrainingTraining ProgramsTranscriptionTranscriptional Regulatory ElementsTransforming GenesTumor Suppressor ProteinsUniversitiesWorkYAF1adulthoodadvisory teamblood cell formationblood disorderblood lossbone marrow failure syndromecareercareer developmentcomplementationdemethylationdensitydesigndesigningdevelopmentaldriver lesiondriver mutationeffective therapyeffective treatmentepigenetic therapyepigeneticallygene expression patterngene expression signaturegenetic trans acting elementgenome mutationgenome scalegenome-widegenomewideimprovedinsightinvestigator trainingmRNA Precursormouse modelmurine modelmutantmyelodysplasianew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachpathwaypatient derived xenograft modelpre-clinical studypreclinical studyprematureprematuritypreventpreventingpromoterpromotorprotein degradationregulatory generesponsesocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttat-Associated Kinasetherapeutic targetthree dimensionaltrans acting elementtranscriptional profiletranscriptional signaturetumor suppressor
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PROJECT SUMMARY/ABSTRACT:
This proposal for a Mentored Clinical Scientist Research Career Development Award (K08) outlines a
comprehensive training program for the career development of the applicant Dr. Prajwal Boddu as an
independent physician scientist. The focus of scientific investigation is myelodysplastic syndrome (MDS), the
most common…
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