grant
Therapeutic Targeting of Mitochondria in Uromodulin-Associated Chronic Kidney Disease
Organization ST. LOUIS VA MEDICAL CENTERLocation St. Louis, UNITED STATESPosted 1 Sept 2024Deadline 31 Aug 2028
VANIHUS FederalResearch GrantFY202521+ years oldAccelerationActive OxygenAddressAdeno-Associated VirusesAdultAdult HumanAmericanApoptosisApoptosis PathwayAscending Limb of Henle's LoopAstrocytesAstrocytusAstrogliaAutoregulationBiogenesisBiological Response Modifier TherapyBiological TherapyBiologyBlood SerumCRE RecombinaseCRISPRCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas systemCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCell BodyCell Communication and SignalingCell DeathCell SignalingCell modelCellsCellular modelChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureClustered Regularly Interspaced Short Palindromic RepeatsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyDNA mutationDataDeletion MutationDependoparvovirusDependovirusDiabetic Kidney DiseaseDiabetic NephropathyDiseaseDisease ProgressionDisorderER stressEnterobacteria phage P1 Cre recombinaseEpithelial CellsExtravasationExtremitiesFibrosisFrequenciesGene ActivationGene DeletionGene variantGeneral PopulationGeneral PublicGenetic ChangeGenetic defectGenetic mutationGoalsHealthHomeostasisHumanHyperactivityImmuneImmunesImpairmentIn SituIn VitroInfiltrationInflammationInflammatoryInjuryIntracellular Communication and SignalingInvestigatorsKO miceKidneyKidney DiseasesKidney FailureKidney InsufficiencyKidney Urinary SystemKnock-out MiceKnockout MiceLeadLeakageLegal patentLimb structureLimbsLoxP-flanked alleleMacrophageMediatingMedicalMiceMice MammalsMitochondriaMitochondrial DNAModelingModern ManMolecularMurineMusMutationMφNGF ReceptorsNeighborhoodsNephropathyNerve Growth Factor ReceptorsNeurotrophic Factor ReceptorNeurotrophin ReceptorsNon-TrunkNull MouseOnset of illnessOrganellesOrigin of LifeOxidative PhosphorylationOxidative Phosphorylation PathwayOxygen RadicalsPET/CTPET/CT scanPatentsPathogenesisPathologicPathway interactionsPatientsPb elementPhysiological HomeostasisPopulationPositionPositioning AttributePrevalencePro-OxidantsProgrammed Cell DeathProteinsQuality ControlReactive Oxygen SpeciesRegulationRenal DiseaseRenal FailureRenal InsufficiencyRenal functionResearchResearch PersonnelResearchersRoleSerumSignal TransductionSignal Transduction SystemsSignalingSpillageStimulator of Interferon GenesStressStructure of ascending limb of Henle's loopTHGPTHP geneTHP proteinTestingTherapeuticThickThicknessTransgenic MiceTubularTubular formationUMODUMOD geneValidationVariantVariationVeteransadeno associated virus groupadulthoodallelic variantastrocytic gliaautosomebacteriophage P1 recombinase Crebiological signal transductionbiological therapeuticbiological treatmentbiologically based therapeuticsbiotherapeuticsbiotherapycGAMP STINGcGAMP-STINGcGAMP/STINGcGAS/STINGcausal allelecausal genecausal mutationcausal variantcausative mutationcausative variantcell imagingcellular imagingchronic kidney diseaseclinical translationclinically translatableconditional knock-outconditional knockoutcyclic GMP-AMP synthase/STINGdisease onsetdisorder onsetendoplasmic reticulum stressfloxedfloxed allelegene deletion mutationgenetic variantgenome mutationgenomic variantheavy metal Pbheavy metal leadhypertensiveimaging detectionimaging-based detectionimaging-based disease detectionimprovedin vivoinjuredinjuriesinnovateinnovationinnovativeinnovative technologiesinsightkidney disorderkidney dysfunctionkidney fibrosiskidney functionmetagenomemitochondrialmitochondrial based therapeuticsmitochondrial targeted therapeuticsmitochondrial therapeuticsmitotherapeuticsmouse modelmtDNAmurine modelmutantnecrocytosisneurotrophic factorneurotrophinneutrophinnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachoverexpressoverexpressionpathwaypositron emission computed tomographypreservationprogramsrenalrenal disorderrenal dysfunctionrenal fibrosisscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttooltranslational opportunitiestranslational potentialuromodulinvalidations
Description preview
Uromodulin (UMOD)-associated chronic kidney disease (CKD), or autosomal dominant tubulointerstitial kidney
disease caused by UMOD mutations (ADTKD-UMOD), is characterized by progressive renal fibrosis and CKD.
Currently there is no targeted therapy. The disease is frequently manifested until adulthood and its prevalence
has been significantly…
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