grant
Therapeutic Potentials of a New Long Noncoding RNA in Diabetic Bone Wound Repair
Organization TUFTS UNIVERSITY BOSTONLocation BOSTON, UNITED STATESPosted 16 Aug 2022Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2024Adult-Onset Diabetes MellitusAnti-diabetic AgentsAnti-diabetic DrugsBinding ProteinsBiocompatible MaterialsBiological FunctionBiological ProcessBiologyBiomaterialsBiomechanicsBisphosphonatesBlood GlucoseBlood SugarBone DiseasesBone FormationBone RegenerationBone ResorptionBone TissueBostonCalcitoninCalcitrinCell FunctionCell PhysiologyCell ProcessCellular FunctionCellular PhysiologyCellular ProcessCellular biologyChondrocytesClinicClinical TrialsCodeCoding SystemCoinComplicationDNA Molecular BiologyDataDefectDevelopmentDiabetes MellitusDiabetic mouseDiseaseDisorderDoseDrug DeliveryDrug Delivery SystemsDrug TargetingDrugsDysfunctionEpidemicEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExperimental PathologyFamilyFoundationsFracture HealingFunctional RNAFunctional disorderFutureGene ExpressionGenesHealthHyperglycemiaImpaired tissue repairImpaired wound healingIncidenceInvestigatorsKO miceKetosis-Resistant Diabetes MellitusKnock-out MiceKnockout MiceL-LysineLaboratoriesLengthLigand Binding ProteinLigand Binding Protein GeneLinkLysineMaturity-Onset Diabetes MellitusMedicationMethodsMiceMice MammalsMolecularMolecular BiologyMurineMusNIDDMNatural regenerationNew JerseyNon-CodingNon-Coding RNANon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNon-Polyadenylated RNANon-translated RNANoncoding RNANoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNontranslated RNANucleotidesNull MouseOsteoblastsOsteoclastic Bone LossOsteoclastsOsteogenesisOutcomePTH geneParathyrinParathyroid HormonePathogenesisPathologicPathway interactionsPatientsPersonsPharmaceutical PreparationsPhenotypePhysiopathologyPlayProtein BindingRNARNA BindingRNA Gene ProductsRNA based therapeuticsRNA based therapyRNA boundRNA therapyRegenerationResearchResearch PersonnelResearchersRibonucleic AcidRoleSERMsSelective Estrogen Receptor ModulatorsSiteSlow-Onset Diabetes MellitusStable Diabetes MellitusSubcellular ProcessSystemT2 DMT2DT2DMTechniquesTechnologyTherapeuticTherapeutic EffectThyrocalcitoninTranscriptTranscription ProcessType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUniversitiesUntranslated RNAWound Repairabnormal tissue repairadipogenesisadult onset diabetesanti-diabeticbiological materialbiomechanicalbiphosphonatebisphosphonatebonebone cellbone disorderbone fracture healingbone fracture repairbone healingbone metabolismbone tissue formationbone wound healingbound proteincell biologycell typedelayed wound healingdetermine efficacydevelopmentaldiabetesdiabetes mouse modeldiabeticdiabetic bone diseasediphosphonatedrug/agentefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationepigeneticallyevaluate efficacyexamine efficacyfracture repairfracture riskhistone methylationhuman diseasehyperglycemicketosis resistant diabetesknockout genelipid biosynthesislipogenesisloss of functionmaturity onset diabetesmouse modelmurine modelnano particlenano-sized particlenanoparticlenanosized particlenew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnoncodingnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetosseous wound healingosteogenicparathormonepathophysiologypathwaypharmacologicposttranscriptionalpreventpreventingrecruitregenerateregenerate boneside effectskillssocial roletherapeutic RNAtherapeutic targettherapeutically effectivetissue repairtranslational studytype 2 DMtype II DMtype two diabeteswound healingwound recoverywound resolution
Description preview
Patients with type 2 diabetes (T2D) have substantially higher incidence of bone disorders, including as
much as a 64% greater risk of fracture as compared to those without T2D. High blood glucose levels adversely
alter bone cell functions, causing decreased bone formation and delayed wound healing with poor quality
tissue repair. Therefore,…
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