grant
The XPA scaffold protein in Nucleotide Excision Repair
Organization VANDERBILT UNIVERSITYLocation Nashville, UNITED STATESPosted 9 Feb 2018Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025AffectAffinityAssayBindingBinding SitesBioassayBiological AssayCDDPCXPDCancer CauseCancer EtiologyCancer TreatmentCancer cell lineCancersCell BodyCellsCis-diammine-dichloroplatinumCis-diamminedichloridoplatinumCis-diamminedichloro Platinum (II)Cis-dichloroammine Platinum (II)Cis-platinous Diamine DichlorideCis-platinum IICis-platinum II Diamine DichlorideCisplatinCisplatinaCisplatinumClinicCombining SiteCysplatynaDNADNA DamageDNA Damage RepairDNA Excision Repair Protein ERCC-1DNA Excision Repair Protein ERCC-2DNA InjuryDNA RepairDNA mutationDNA replication factor ADNA-Repair Protein Complementing XP-D CellsDNA-Repair Protein XPDDataDefectDeoxyribonucleic AcidDevelopmentDichlorodiammineplatinumDrugsDysfunctionEM9ERCC-2 proteinERCC1ERCC1 geneERCC2ERCC2 geneEvaluationExcision Repair Cross-Complementation Group 1Excision Repair Cross-Complementing 1Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 1Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 ProteinFoundationsFunctional disorderGenerationsGenetic ChangeGenetic defectGenetic mutationGenomicsGoalsGroup D XPHumanInorganic Platinum CompoundsKnowledgeLeadLibrariesLinkLocationMalignant CellMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMedicationMissense MutationModelingModern ManMolecularMolecular InteractionMutateMutationNucleotide Excision RepairNucleotide Excision Repair InhibitionPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPb elementPeyrone's ChloridePeyrone's SaltPharmaceutical PreparationsPhysiopathologyPlatinumPlatinum AgentsPlatinum BlackPlatinum CompoundsPlatinum DiamminodichlorideProcessProteinsPt elementPublicationsRAD10RadiationReactive SiteReporterResearchResistanceScaffolding ProteinScientific PublicationSingle Crystal DiffractionTFIIH Basal Transcription Factor Complex Helicase SubunitTestingTherapeuticTherapeutic InterventionToxinTumor CellUnscheduled DNA SynthesisWorkX Ray CrystallographiesX-Ray CrystallographyX-Ray Diffraction CrystallographyX-Ray/Neutron CrystallographyXP-AXP4XPD GeneXPD proteinXPDCXenograft ModelXeroderma Pigmentosum Complementation Group AXeroderma Pigmentosum Group D Complementing ProteinXeroderma pigmentosum complementation group D proteinXray Crystallographyanti-cancer therapyanti-cancer treatmentanti-tumor drugcancer cellcancer cell genomecancer genomecancer therapycancer typecancer-directed therapychemotherapycis dichlorodiammineplatinumcis platinum compoundcis-Diaminedichloroplatinumcis-Diamminedichloroplatinumcis-Diamminedichloroplatinum(II)cis-Dichlorodiammineplatinum(II)cis-Platinumcombinatorialdesigndesigningdevelopmentaldrug sensitivitydrug/agentgene repairgenome databasegenome mutationheavy metal Pbheavy metal leadimprovedinhibitorinsightintervention therapyloss of function mutationmalignancymissense single nucleotide polymorphismmissense single nucleotide variantmissense variantmutantneoplasm/cancerneoplastic cellpathophysiologypathwaypatient oriented outcomesprecision medicineprecision-based medicinerepairrepairedreplication factor Areplication protein Aresistantscaffoldscaffoldingsingle-strand binding protein RP-Asmall molecular inhibitorsmall molecule inhibitortherapeutic evaluationtherapeutic testingtooltool developmenttranslational opportunitiestranslational potentialtumortumor genomexenograft transplant modelxenotransplant model
Description preview
SUMMARY
Nucleotide excision repair (NER) protects human cells by removing harmful DNA damage, but repair of
damaged DNA by NER can reduce the efficacy of some antitumor drugs such as cisplatin. NER genes are
frequently missense mutated in cancers and decreased expression or loss of function mutation of NER genes
ERCC1 and ERCC2, respectively, has…
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