grant

The Transmission Biology of Mycobacterium Tuberculosis

Organization WEILL MEDICAL COLL OF CORNELL UNIVLocation NEW YORK, UNITED STATESPosted 22 Jun 2021Deadline 31 May 2027
NIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoVAccess to CareAerosolsAirAlveolusAtmosphereBacillusBase Excision RepairsBiochemical PathwayBiologyBreathingBronchial AlveolusCOVID-19COVID-19 virusCOVID19 virusCRISPR interferenceCRISPR-dCas9-mediated repressionCRISPR/dCas9 interferenceCRISPR/dCas9-mediated transcriptional inhibitionCRISPRiCV-19CarbonCause of DeathCell BodyCell FunctionCell NucleusCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessCessation of lifeChemicalsChrysemonasClinicalClustered Regularly Interspaced Short Palindromic Repeats interferenceCoV-2CoV2Communicable DiseasesCoronavirus Infectious Disease 2019D pneumoniaeD. pneumoniaeDNA Base Excision RepairDNA DamageDNA InjuryDataDeathDepositDepositionDesiccationDessicationDetectionDevelopmentDiagnosticDiameterDiplococcus pneumoniaeDisciplineDiseaseDisorderDoctor of PhilosophyDrynessEnzyme GeneEnzymesEventExposure toFlavimonasGene ExpressionGene InactivationGene SilencingGenerationsGoalsGrantGrippeHealth Care ProfessionalHealth ProfessionalHealth Services AccessibilityHouseholdHuman FigureHuman bodyHydrationHydration statusHydrogen OxideImmune SurveillanceImmunityImmunologic SurveillanceImmunosurveillanceImprove AccessIncidenceIndividualInfectionInfectious DiseasesInfectious DisorderInfluenzaInhalationInhalingIntermediary MetabolismInvestigationLaboratoriesLife CycleLife Cycle StagesLower respiratory tract structureLungLung Respiratory SystemM tbM tuberculosisM tuberculosis infectionM. tbM. tb infectionM. tuberculosisM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMTB infectionMapsMedicineMetabolicMetabolic NetworksMetabolic PathwayMetabolic ProcessesMetabolismMethodsMicrobiologyMolecularMycobacterium tuberculosisMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionNew York CityNucleotide BiosynthesisNucleotidesNucleusOrganismOxidative StressOxidative Stress InductionPathway interactionsPh.D.PhDPneumococcusPopulationPositionPositioning AttributePredispositionProcessProvincial GovernmentPseudomonasRecoveryResearchResearch TrainingRespiratory AspirationRespiratory InspirationRespiratory infectious agentRespiratory tract pathogenS pneumoniaeS. pneumoniaeSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV2SARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2SchoolsScientistSecondary toSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome related corona virus 2State GovernmentStreptococcus pneumoniaeStressSubcellular ProcessSusceptibilitySuspension substanceSuspensionsTB infectionTestingTrainingTransmissionTransportationTrehaloseTuberculosisVaccinationVirusWaterWorkWuhan coronavirusaccess to health servicesaccess to servicesaccess to treatmentaccessibility to health servicesaerosolizedavailability of servicesbiological systemscare accesscareerclastogencomparativecoronavirus disease 2019coronavirus disease 2019 viruscoronavirus disease-19coronavirus disease-19 viruscoronavirus infectious disease-19developmentaldisseminated TBdisseminated tuberculosisglobal healthhCoV19health service accesshealth services availabilityinfection due to Mycobacterium tuberculosisinsightinspirationinstructorinterestinternational health organizationlife courseliving systemlower respiratory tractmedical collegemedical schoolsmetabolism measurementmetabolomicsmetabonomicsmortalitymtbnCoV2new approachesnovelnovel approachesnovel strategiesnovel strategyoxidative damageoxidative injuryparticlepathogenpathwayrepairrepairedrepressing CRISPR-dCas9 systemrespiratory pathogenresponseschool of medicineservice availabilitysuccesstranscriptional silencingtransmission blockingtransmission processtreatment accesstreatment programtuberculosis infectiontuberculous spondyloarthropathyvaccine candidate
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Full Description

PROJECT SUMMARY/ABSTRACT
Christopher Brown MD, PhD is an Instructor of Medicine in the division of infectious diseases at Weill-
Cornell Medical College in New York City. His research interests focus on defining the biology of transmission
in Mycobacterium tuberculosis. This five-year training grant outlines technical, research and professionalism
goals needed to launch an independent academic career. Dr. Brown has extensive research training as an
organic chemist and chemical biologist from his doctoral work in the laboratory of Laura L. Kiessling. This
proposal expands into the fields of microbiology, metabolomics and regulated gene expression. Utilizing a
combination of these disciplines is a powerful method for the molecular interrogation of biological systems.
Mtb transmission biology is a field of substantial opportunity for discovery. Development of a transmission
blocking therapy would have a profound impact on global health and mortality. The research goal of this proposal
is to identify bacterially-encoded determinants that favor successful transmission by imparting survival in air. The
PI will expose laboratory and clinical strains of Mtb to air-drying stress and document the effects on metabolism
and cellular integrity. Hypotheses regarding the essentiality of metabolic pathways for survival will be tested
using CRISPRi (clustered regularly interspersed short palindromic repeat interference) gene silencing.

Grant Number: 5K08AI148584-05
NIH Institute/Center: NIH
Principal Investigator: Christopher Brown

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