grant
The STAT3 Pathway in Uterine Leiomyoma: A Therapeutic Target
Organization NORTHWESTERN UNIVERSITYLocation CHICAGO, UNITED STATESPosted 1 Jan 2025Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY2025APRF proteinAccountingAcute-Phase Response FactorAddressAffectAreaBasal Transcription FactorBasal transcription factor genesBindingBiochemicalBody TissuesCRISPRCRISPR/Cas systemCausalityCell BodyCell Growth in NumberCell LineCell MultiplicationCell NucleusCell ProliferationCell SurvivalCell ViabilityCell-Extracellular MatrixCellLineCellsCellular ExpansionCellular GrowthCellular ProliferationChromatinClinicalClustered Regularly Interspaced Short Palindromic RepeatsDNA AlterationDNA Sequence AlterationDNA mutationDNA-Dependent RNA Polymerase IIDataDefectDevelopmentDevelopment and ResearchDiseaseDisorderECMEngineeringEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEtiologyExpression SignatureExtracellular MatrixFDA approvedFibroidFibroid NeoplasmFibroid TumorFibroid UterusFibromyomaFibrosisFutureGene ActivationGene AlterationGene ExpressionGene Expression ProfileGene MutationGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenesGeneticGenetic AlterationGenetic ChangeGenetic MarkersGenetic TranscriptionGenetic defectGenetic mutationGoalsGrowthHealthHeterograftHeterologous TransplantationHumanHyperactivityHysterectomyIL6-response factorInduced DNA AlterationInduced MutationInduced Sequence AlterationInduction of ApoptosisKinasesL-SerineLIF-response factorLeiomyocyteLeiomyomaLeiomyomatous NeoplasmLeiomyomatous TumorMediatingMediatorMedicalModern ManMolecular InteractionMutateMutationMyometrialNational Institutes of HealthNucleusOvarian Steroid HormonePDX modelPathogenesisPathogenicityPathologyPathway interactionsPatient derived xenograftPatientsPatternPhosphorylationPhosphotransferase GenePhosphotransferasesPhysiologicPhysiologicalPopulationProcessProductionProgesterone ReceptorsProgestin ReceptorsPropertyProtein PhosphorylationR & DR&DRNA ExpressionRNA Polymerase BRNA Polymerase IIRecombinant Oncostatin MRecurrenceRecurrentResearch PriorityResearch SpecimenRoleSamplingSequence AlterationSerineSignal Transducer and Activator of Transcription 3Single-Nucleus SequencingSmooth Muscle CellsSmooth Muscle MyocytesSmooth Muscle Tissue CellSpecimenStat3 proteinStrains Cell LinesSymptomsTestingTherapeutic InterventionTherapeutic Steroid HormoneTissue GrowthTissuesTranscriptionTranscription ActivationTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ActivationTranslational ResearchTranslational ScienceTransphosphorylasesTumor PromotionTyrosineUnited States National Institutes of HealthUterine Body FibroidUterine Body LeiomyomaUterine Corpus FibroidUterine Corpus LeiomyomaUterine FibroidsUterine FibromaUterine LeiomyomaUterine MuscleUterus FibromaWomanWorkXenograftXenograft procedureXenotransplantationcausationcell growthclinical relevanceclinically relevantcorpus uteri fibroidcorpus uteri leiomyomacultured cell linecytokinedevelopmentaldisease causationdriver lesiondriver mutationepigeneticallyexperiencegene biomarkergene defectgene expression biomarkergene expression patterngene expression signaturegene markergene signature biomarkergenetic biomarkergenome mutationgenomic alterationin vivoinhibitorinsightintervention therapylong read seqlong-read sequencinglong-read transcript sequencingmouse modelmultiomicsmultiple omicsmurine modelmutant allelemyometriumneoplasticnoveloncostatin Montogenypanomicspathwaypatient derived xenograft modelpharmacologicprecision medicineprecision-based medicinepromoterpromotorreceptor bindingreceptor boundresearch and developmentresponsesNuc-Seqsingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqsocial rolesteroid hormonetargeted agenttherapeutic targettranscription factortranscriptional profiletranscriptional signaturetranscriptomicstranslation researchtranslational investigationtumortumor growthuterus leiomyomaxeno-transplantxeno-transplantation
Description preview
ABSTRACT/SUMMARY
Uterine leiomyomas (LMs, fibroids) are the most important neoplastic threat to women worldwide. As no long-
term non-invasive treatment option exists for LMs, deeper insight into tumor etiology is key to develop more
effective medical therapies. Accordingly, this proposal is impactful as it suggests a novel etiological basis for…
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