grant
The Serine Protease HTRA1 Antigen: A Gateway to Elucidating Membranous Nephropathy Pathogenesis and the Targeting of Antigen Epitopes
Organization UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAHLocation SALT LAKE CITY, UNITED STATESPosted 21 Jul 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2026AlbuminuriaAnimal ModelAnimal Models and Related StudiesAnimalsAntibodiesAntibody titer measurementAntigen TargetingAntigen-Antibody ComplexAntigenic DeterminantsAntigensAssayAutoantibodiesAutoantigensAutoimmune DiseasesAutoimmune MechanismAutoimmune ProcessAutoimmune ResponsesAutologous AntigensAutomobile DrivingAutoregulationAwardBasement membraneBindingBinding DeterminantsBioassayBiological AssayBloodBlood Reticuloendothelial SystemBlood SerumBody TissuesBrainBrain Nervous SystemBruch MembraneBruch's basal membrane structureBruch's membraneBruchs membraneCareer ChoiceCareer PathCell-Extracellular MatrixChIP assayCirculationClinicClinicalClinical ResearchClinical StudyCommunicationDataDepositDepositionDevelopmentDiagnosisDiseaseDisorderDomestic RabbitECMESKDESRDEducationEducational aspectsElectron MicroscopyEncephalonEnd stage renal failureEnd-Stage Kidney DiseaseEnd-Stage Renal DiseaseEndothelial CellsEnsureEpitopesEsteroproteasesEventExtracellular MatrixExtracellular Matrix ProteinsExtramembranous GlomerulopathyEyeEye diseasesEyeballFiltrationFiltration FractionationFoundationsGenerationsGlomerular diseaseGoalsHeteroantibodiesHeterogenetic AntibodiesHeterologous AntibodiesHeterophil AntibodiesHeterophile AntibodiesHeterotypic AntibodiesHistologicHistologicallyHomeostasisHumanImmune ComplexImmune responseImmunizationImmunizeImmunofluorescenceImmunofluorescence ImmunologicImmunologyIn SituIn VitroInjuryInvestigatorsJunior PhysicianKO miceKidneyKidney DiseasesKidney GlomerulusKidney Urinary SystemKnock-out MiceKnockout MiceKnowledgeLaboratoriesLamina Basalis ChoroideaeLeadershipMalpighian TuftMediatingMembranous GlomerulonephritisMembranous GlomerulonephropathyMembranous GlomerulopathyMembranous NephropathyMentorsMentorshipMiceMice MammalsModelingModern ManMolecular InteractionMurineMusNephrologyNephropathyNephrotic SyndromeNull MouseOrganOryctolagus cuniculusPathogenesisPathogenicityPathologicPathologyPatientsPeptidasesPeptide HydrolasesPeptidesPhysiological HomeostasisPre-Clinical ModelPreclinical ModelsProductionProtease DomainProtease GeneProteasesProtein FragmentProtein SecretionProteinasesProteinsProteinuriaProteolytic DomainProteolytic EnzymesProteomicsRabbitsRabbits MammalsRenal DiseaseRenal Glomerular Diseases and SyndromesRenal glomerular diseaseRenal glomerular disease or syndromeRenal glomerular disorderRenal glomerular syndromeResearchResearch PersonnelResearch ResourcesResearchersResourcesRodentRodentiaRodents MammalsRunningScientistSelf-AntigensSerine EndopeptidasesSerine ProteaseSerine Protein HydrolasesSerine ProteinasesSerumSiteStructureTestingTherapeuticTimeTissuesTrainingTraining ActivityTransgenic ModelTreatment outcomeUniversitiesUtahVisceral Epithelial CellXenoantibodiesXenogeneic AntibodiesXenogenic Antibodiesantibody titeringautoimmune antibodyautoimmune conditionautoimmune disorderautoimmunity diseaseautoreactive antibodycareer aspirationcareer developmentcareer interestcareer pathwaycareer trackchip modelchip systemchromatin immunoprecipitationclinical developmentclinical relevanceclinically relevantcohortdesigndesigningdevelopmentaldrivingexperienceexposure researchexposure scienceeye disorderglomerular basement membraneglomerular filtrationglomerular visceral epithelial cellhost responseimmune system responseimmunogenimmunoresponseimprovedin vivoinjuriesinsightkidney disorderkidney glomerulimodel of animalnovelocular diseaseocular disorderon a chipon chipophthalmopathyoverexpressoverexpressionpodocyteprogramsprotein functionprotein protein interactionrenalrenal disorderrenal glomerulusresponseself reactive antibodyskillstraining moduletransgenic traittrypsin-like serine protease
Description preview
Abstract
Primary membranous nephropathy (MN) is a major cause of nephrotic syndrome and kidney diseases.
This autoimmune condition is characterized by the accumulation of immune complexes along the glomerular
basement membrane (GBM). What triggers autoantibody production and its contribution to organ damage in MN
remains incompletely understood.…
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