grant
The roles of ceramide and its derivatives in A. phagocytophilum pathogenesis
Organization VIRGINIA COMMONWEALTH UNIVERSITYLocation RICHMOND, UNITED STATESPosted 6 Jun 2018Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025A phagocytophilaA phagocytophilumA. phagocytophilaA. phagocytophilumAccelerationAddressAnaplasma phagocytophilaAnaplasma phagocytophilumAnaplasmosisBacteriaBinding SitesBiogenesisBiological SymbiosisBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood granulocytic cellC-jun Amino-Terminal KinaseC-jun Kinase-1C-jun N-Terminal Kinase 1CausalityCell BodyCell CommunicationCell Communication and SignalingCell FunctionCell InteractionCell PhysiologyCell ProcessCell SignalingCell membraneCell-to-Cell InteractionCellsCellular FunctionCellular PhysiologyCellular ProcessCeramidesCholesterolCombining SiteCommunicable DiseasesCytoecetes phagocytophilaCytoplasmic MembraneDataDevelopmentDiseaseDisorderEhrlichia equiEhrlichia phagocytophilaEndosomesEndothelial CellsEnzyme GeneEnzymesEtiologyExocytosisFosteringFundingGeneralized GrowthGolgiGolgi ApparatusGolgi ComplexGranular LeukocytesGranulocytic cellGrowthHGE AgentHL-60 CellsHL60 CellsHumanImmunityIn VitroIncidenceInfectionInfectious DiseasesInfectious DisorderInflammationIntermediary MetabolismIntracellular Communication and SignalingJN KinaseJNKJNK Mitogen-Activated Protein KinasesJNK1JNK1 KinaseJNK1 proteinJNK1A2JNK21B1/2KnowledgeLinkLipidsMAP Kinase 8MAP Kinase 8 GeneMAPK8MAPK8 Mitogen-Activated Protein KinaseMAPK8 geneMarrow NeutrophilMediatingMembraneMetabolicMetabolic ProcessesMetabolismMiceMice MammalsMitogen-Activated Protein Kinase 8ModelingModern ManMolecularMolecular Modeling Nucleic Acid BiochemistryMolecular Modeling Protein/Amino Acid BiochemistryMolecular ModelsMultivesicular BodyMurineMusMyeloid CellsNational Institutes of HealthNeutrophilic GranulocyteNeutrophilic LeukocyteOrganellesOrigin of LifePIP2PRKM8ParasitesPathogenesisPathogenicityPathway interactionsPhosphatesPhosphatidylinositol 4,5-BiphosphatePhosphatidylinositol 4,5-DiphosphatePhosphatidylinositol-4,5-BisphosphatePhosphorylationPlasma MembranePolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPremyelocytesProcessProgranulocytesProliferatingPromyelocyteProtein PhosphorylationProteinsProteomicsPtIns 4,5-P2PtdInsP2Reactive SiteReceptosomesResearchRoleSAP Kinase-1SAPK/JNKSAPK1 Mitogen-Activated Protein KinaseSAPK1/JNKSignal TransductionSignal Transduction SystemsSignalingSortingSphingolipidsSphingomyelinsStealingStress-Activated Protein Kinase JNK1Stress-Activated Protein Kinase gammaSubcellular ProcessTestingTheftTick-Borne DiseasesTissue GrowthUnited States National Institutes of HealthVacuoleVesicleWorkbiological signal transductionc-jun N-Terminal Kinasecausationceramide 1-phosphateceramide kinasedefined contributiondevelopmentaldisease causationemerging human pathogenexosomegranulocytehost microbe associationhost microbe relationshiphost-microbe interactionshost-microbial interactionshost-microorganism interactionsimmunopathologyimprovedin vivoinfectious disease treatmentinnovateinnovationinnovativeinorganic phosphatejun-NH2-Terminal Kinaselipidomicsmembrane structuremicrobialmolecular modelingneutrophilnovelontogenyparasitismpathogenpathwayplasmalemmarecruitresponsesocial rolestress-activated protein kinase 1tick-borne illnesstickborne diseasetickborne illnesstooltraffickingtrans-Golgi Network
Description preview
Anaplasma phagocytophilum (Ap) is an obligate intracellular bacterium that causes the emerging and potentially
fatal infection, human granulocytic anaplasmosis (HGA). The microbial-host interactions that facilitate Ap
intracellular proliferation and dissemination have remained poorly characterized. We uncovered a novel role for
the host bioactive…
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