grant
The role of VacA in Helicobacter pylori-host cell cholesterol homeostasis
Organization VANDERBILT UNIVERSITYLocation Nashville, UNITED STATESPosted 1 Jul 2025Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AddressAreaAssayBacteriaBindingBioassayBiological AssayBuffersC pyloriC. pyloriCampylobacter pyloriCancer CauseCancer Causing AgentsCancer EtiologyCancersCarcinogensCell BodyCell Culture TechniquesCell DeathCell FunctionCell LineCell PhysiologyCell ProcessCell membraneCellLineCellsCellular FunctionCellular MembraneCellular PhysiologyCellular ProcessCessation of lifeCholesterolCholesterol HomeostasisClinicalCo-cultureCocultivationCocultureCoculture TechniquesCytoplasmic MembraneCytotoxinDeathDevelopmentDiseaseDisease OutcomeDisorderEndoplasmic ReticulumEnvironmentEnzyme GeneEnzymesEpithelial CellsErgastoplasmGastric AdenocarcinomaGastric Body CancerGastric CancerGastric Cardia CancerGastric DiseasesGastric Fundus CancerGastric Pylorus CancerGastric lymphomaGastroduodenal UlcerGene ExpressionGene set enrichment analysisGenesGenetic DiversityGenetic VariationGram-Negative BacteriaH pyloriH pylori infectionH pyloryH. pyloriH. pylori infectionH. pyloryHealthHelicobacter InfectionsHelicobacter Pylori InfectionHelicobacter pyloriHourHumanIncidenceIncubatedIndividualInfectionInterventionIntoxicationLDL CholesterolLDL Cholesterol LipoproteinsLinkLiquid ChromatographyLow Density Lipoprotein CholesterolMalignantMalignant - descriptorMalignant Gastric NeoplasmMalignant Gastric TumorMalignant NeoplasmsMalignant TumorMediatingMembraneMetabolic GlycosylationModern ManMolecular InteractionNon-Polyadenylated RNANutrientOncogensOutcomePathogenesisPathogenicity FactorsPathway interactionsPeptic UlcerPeptic Ulcer DiseasePlasma MembranePopulationProcessRNARNA Gene ProductsRNA SeqRNA sequencingRNAseqResearchRibonucleic AcidRisk FactorsRoleSterol BiosynthesisSterol Biosynthesis PathwaySterolsStomachStomach AdenocarcinomaStomach CancerStomach DiseasesStrains Cell LinesSubcellular ProcessSwellingTestingTimeToxinTranscriptVariantVariationVirulence FactorsWorld Health Organizationbeta-Lipoprotein Cholesterolcancer riskcell culturecell culturescholesterol analogcholesterol biosynthesischolesterol metabolismconfocal imagingcultured cell linecytotoxicdevelopmentaldifferences in healthdifferential expressiondifferentially expresseddisease riskdisorder riskenzyme biosynthesisexperimentexperimental researchexperimental studyexperimentsfitnessgastricgastric malignancyglycosylationhealth differencehigh riskinsightlate endosomemalignancymalignant stomach neoplasmmalignant stomach tumormembrane structuremitochondrial dysfunctionmutantnecrocytosisneoplasm/cancernoveloncogenic agentpathwayplasmalemmaresponsesocial rolestomach disorderstomach fundus cancerstomach lymphomastomach pylorus cancertandem mass spectrometrytraffickingtranscriptional differencestranscriptome sequencingtranscriptomic sequencinguptake
Description preview
PROJECT SUMMARY (ABSTRACT)
Helicobacter pylori is a Gram-negative bacterium that colonizes the stomachs of about half the world’s human
population. Although most infected individuals remain asymptomatic, H. pylori infection can lead to adverse
health outcomes, including peptic ulcer disease, gastric adenocarcinoma, or gastric lymphoma. H. pylori…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click