grant
The Role of Tomosyn-1 in Regulating Insulin Secretion from Pancreatic beta-cells
Organization UNIVERSITY OF ALABAMA AT BIRMINGHAMLocation BIRMINGHAM, UNITED STATESPosted 5 Apr 2019Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY202621+ years old3'5'-cyclic ester of AMPAdenosine Cyclic 3',5'-MonophosphateAdenosine Cyclic MonophosphateAdenosine Cyclic Monophosphate-Dependent Protein KinasesAdenosine, cyclic 3',5'-(hydrogen phosphate)AdultAdult HumanAdult-Onset Diabetes MellitusAffectAssayBeta CellBindingBinding ProteinsBioassayBiochemicalBiological AssayBlood GlucoseBlood PlasmaBlood SugarCell Communication and SignalingCell FunctionCell LineCell PhysiologyCell ProcessCell SignalingCell membraneCellLineCellular FunctionCellular PhysiologyCellular ProcessCompetenceComplexCoupledCuesCyclic AMPCyclic AMP-Dependent Protein KinasesCytoplasmic MembraneD-GlucoseDextroseDiabetes MellitusDiseaseDisorderDysfunctionE3 LigaseE3 Ubiquitin LigaseEventExhibitsExocytosisFunctional disorderGLP-1Genetics-MutagenesisGlp-1GlucoseGoalsHigh Fat DietHumanHumulin RImageImpairmentInsulinInsulin AntagonistsInsulin CellInsulin Secreting CellIntracellular Communication and SignalingKO miceKetosis-Resistant Diabetes MellitusKnock-out MiceKnockout MiceKnowledgeLeannessLigand Binding ProteinLigand Binding Protein GeneLinkMaturity-Onset Diabetes MellitusMediatingMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMetabolicMetabolic Clearance RateMetabolic Protein DegradationMethodsMiceMice MammalsMissionModern ManMolecularMolecular InteractionMolecular TargetMurineMusMutagenesisMutagenesis Molecular BiologyNIDDMNSF attachment proteinNSF attachment protein receptorNational Institutes of HealthNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin RNull MouseNutritionalObese MiceObesityOutcomePKAPancreatic beta CellPancreatic β-CellPersonsPhasePhosphorylationPhosphorylation SitePhysiologicPhysiologicalPhysiologyPhysiopathologyPlasmaPlasma MembranePlasma SerumPopulationPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPre-DMPrediabetesPrediabetes syndromePrediabetic StatePredispositionProtein BindingProtein Kinase AProtein ModificationProtein PhosphorylationProtein TurnoverProteinsPublic HealthRegular InsulinRegulationRegulatory Protein DegradationReticuloendothelial System, Serum, PlasmaRoleSNAP receptorSNARESignal PathwaySignal TransductionSignal Transduction SystemsSignalingSlow-Onset Diabetes MellitusStable Diabetes MellitusStimulusStrains Cell LinesStructure of beta Cell of isletSubcellular ProcessSurface ProteinsSusceptibilityT2 DMT2DT2DMTestingTherapeuticThinnessType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUbiquitilationUbiquitin Protein LigaseUbiquitin-Protein Ligase ComplexesUbiquitin-Protein Ligase E3UbiquitinationUbiquitinoylationUnited StatesUnited States National Institutes of Healthadenosine 3'5' monophosphateadiposityadult onset diabetesadulthoodattenuated insulin secretionbiological signal transductionblood glucose regulationblunted insulin secretionbound proteincAMPcAMP-Dependent Protein Kinasesclearance ratecompare to controlcomparison controlcorpulencecultured cell linedecreased insulin releasedecreased insulin secretiondefective insulin secretiondiabetesdiet-associated obesitydiet-induced obesitydiet-related obesitydiminished insulin releasediminished insulin secretionglucagon-like peptide 1glucose controlglucose homeostasisglucose regulationglucose tolerancehormonal regulationhormone regulationimagingimpaired glucose toleranceimpaired insulin releaseimpaired insulin secretionimprovedinadequate insulin releaseinadequate insulin secretioninhibitorinsightinsulin granuleinsulin inhibitorinsulin secretioninsulin sensitivityisletketosis resistant diabetesknock-downknockdownlowered insulin secretionmaturity onset diabetesmouse modelmurine modelnon-diabeticnondiabeticnutritiousob/ob mousepancreas beta cellpancreas β cellpancreatic b-cellpathophysiologyplasmalemmapre-diabetespre-diabeticprediabeticpreventpreventingprotein degradationrecruitreduced insulin releaseresponsesecretion processsocial rolesoluble N-ethylmaleimide-sensitive factor attachment proteinsoluble N-ethylmaleimide-sensitive fusion attachment proteinsoluble N-ethylmaleimide-sensitive-factor attachment protein receptorsoluble NSF attachment proteinsuppressed insulin releasesuppressed insulin secretionsynaptotagminsyntaxintype 2 DMtype II DMtype two diabetesubiquinationubiquitin conjugationubiquitin-protein ligaseβ-cellβ-cellsβCell
Description preview
Type 2 diabetes (T2D) affects ~10% of the US adult population, and another 84.1 million have prediabetes. The
β-cell dysfunction is an early and essential event in an impaired glucose tolerant state (IGT) that leads to
diabetes, including obesity-linked T2D. The formation of SNARE complexes is rate-limiting for the fusion of
insulin granules to…
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