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The role of tissue nonspecific alkaline phosphatase in brain endothelial cell homeostasis
Organization WEST VIRGINIA UNIVERSITYLocation MORGANTOWN, UNITED STATESPosted 1 Jun 2021Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY20257B4 Antigen7B4 proteinAddressAgeAgingAlkaline PhosphataseApoplexyArterial ObstructionArterial OcclusionArtery ObstructionAutoregulationBBB permeabilizationBBB permeableBehavioralBiologyBlood - brain barrier anatomyBlood PreservationBlood VesselsBlood-Brain BarrierBody TissuesBrainBrain DiseasesBrain DisordersBrain Nervous SystemBrain VascularBrain Vascular AccidentBrain Vascular DisordersCD144 AntigenCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellular FunctionCellular PhysiologyCellular ProcessCerebral IschemiaCerebral StrokeCerebral endotheliumCerebrovascular ApoplexyCerebrovascular DiseaseCerebrovascular DisordersCerebrovascular StrokeCerebrumCre driverDataDiseaseDisorderDysfunctionEncephalonEncephalon DiseasesEndothelial CellsEnzyme GeneEnzymesExhibitsExtravasationFemaleFoundationsFunctional disorderGene ExpressionGeneticHealthHemato-Encephalic BarrierHomeostasisHumanIn VitroInjectionsInjuryIntermediary MetabolismIntracellular Communication and SignalingIntracranial CNS DisordersIntracranial Central Nervous System DisordersIntracranial Vascular DiseasesIntracranial Vascular DisordersIschemic StrokeKnowledgeLabelLeakageLinkLoxP-flanked alleleMetabolic ProcessesMetabolismMiceMice MammalsMiddle Cerebral Artery OcclusionMineralsModelingModern ManMolecularMurineMusNervous System DiseasesNervous System DisorderNetwork AnalysisNeurologic DisordersNeurological DisordersOutcomePathologicPathway AnalysisPathway interactionsPermeabilityPhysiologicPhysiologicalPhysiological HomeostasisPhysiopathologyPrediction of Response to TherapyRecovery of FunctionRegulationReperfusion TherapyRho-associated kinaseRho-kinaseRoleSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSpillageStrokeSubcellular ProcessTestingTherapeuticTissuesTracerTreatment EfficacyVE-CadherinVascular Endothelial CadherinVascular Endothelial Cadherin 1after strokeage associatedage associated diseaseage associated disorderage associated impairmentage correlatedage dependentage dependent diseaseage dependent disorderage dependent impairmentage groupage linkedage relatedage related human diseaseage specificage-related diseaseage-related disorderage-related impairmentagedaged brainaged groupaged groupsaged individualaged individualsaged miceaged mouseaged peopleaged personaged personsaged populationaged populationsagesaging associatedaging brainaging populationaging relatedalkaline phosphomonoesteraseartery occlusionastrogliosisbehavior outcomebehavioral outcomebiological signal transductionblood-brain barrier permeabilizationblood-brain barrier permeablebloodbrain barrierbloodbrain barrier permeabilizationbloodbrain barrier permeablebonebrain attackbrain endothelial cellbrain endotheliumbrain healthbrain microvascular endothelial cellbrain microvasculaturebrain microvesselsbrain vascular diseasebrain vascular dysfunctionbrain vascular endothelial cellcadherin 5cerebralcerebral endothelial cellcerebral ischemic damagecerebral ischemic injurycerebral microvascular endothelial cellcerebral microvasculaturecerebral microvesselscerebral vascularcerebral vascular accidentcerebral vascular diseasecerebral vascular dysfunctioncerebral vascular endothelial cellcerebro-vascularcerebrovascularcerebrovascular accidentcerebrovascular dysfunctionconditional knock-outconditional knockoutcortical endotheliumecto-nucleotidaseelderly miceenzyme activityexperimental groupfasudilfloxedfloxed allelefunctional recoveryglycerophosphatasehuman diseaseimprovedin vivoindexinginhibitorinjuredinjuriesintervention efficacyintracranial vascular dysfunctionmalemid lifemid-lifemiddle agemiddle agedmidlifemouse modelmultiphoton excitation microscopymultiphoton microscopymurine modelnatural agingneuro-vascular unitneurological diseaseneurovascular unitnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnormal agingnormative agingnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetold micepathophysiologypathwaypharmacologicpopulation agingpost strokepoststrokepredict therapeutic responsepredict therapy responsepreservationprotection pathwayprotective pathwayreperfusionresponserestorationsocial rolestroke outcomestrokedstrokestherapeutic efficacytherapeutic targettherapy efficacytherapy predictiontooltranslational impacttreatment predictiontreatment response predictionvascular♀♂
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PROJECT SUMMARY
The objective of this application is to determine how tissue nonspecific alkaline phosphatase (TNAP) enzymatic
activity maintains cerebrovascular function within the neurovascular unit (NVU). Brain microvascular endothelial
cells (BMECs) comprise the cerebral microvasculature and serve as the structural foundation of the…
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