grant
The role of Tie2 signaling in Aortic Valve Remodeling
Organization VANDERBILT UNIVERSITY MEDICAL CENTERLocation NASHVILLE, UNITED STATESPosted 10 Aug 2024Deadline 31 May 2028
NIHUS FederalResearch GrantFY20251-Phosphatidylinositol 3-KinaseAKTAffectAgonistAkt proteinAllelesAllelomorphsAnatomic SitesAnatomic structuresAnatomyAutocrine SystemsBasal Transcription FactorBasal transcription factor genesBicuspid ValveBirthBirth DefectsCandidate Disease GeneCandidate GeneCardiacCardiac AbnormalitiesCardiac MalformationCardiac ValvesCausalityCell BodyCell Communication and SignalingCell Growth in NumberCell MultiplicationCell NucleusCell ProliferationCell SignalingCellsCellular ProliferationCollaborationsCongenital AbnormalityCongenital Anatomical AbnormalityCongenital Cardiac DefectsCongenital DefectsCongenital DeformityCongenital Heart DefectsCongenital MalformationCritical PathsCritical PathwaysCultured CellsCytoplasmDataDefectDevelopmentDiseaseDisorderEGF-Like DomainEPH- and ELK-Related Tyrosine KinaseEPH-and ELK-Related KinaseERK 1ERK1ERK1 KinaseEmbryoEmbryonicEmbryonic HeartEndocardiumEndothelial CellsEndotheliumEphrin Type-A Receptor 8Ephrin Type-A Receptor 8 PrecursorEtiologyEventExclusionExposure toExtracellular Matrix ProteinsExtracellular Signal-Regulated Kinase 1Extracellular Signal-Regulated Kinase GeneFKHRFOXO1FOXO1AFOXO1A geneForkhead Box O1AForkhead in RhabdomyosarcomaFoundationsFrequenciesGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGoalsGrowthHarvestHeart AbnormalitiesHeart MalformationHeart Valve DiseasesHeart ValvesHeart failureHistologicHistologicallyHumanImmune GlobulinsImmunoglobulinsIntracellular Communication and SignalingKO miceKnock-outKnock-out MiceKnockoutKnockout MiceLeannessLoxP-flanked alleleMAP Kinase 3MAP Kinase GeneMAPKMAPK3MAPK3 Mitogen-Activated Protein KinaseMAPK3 geneMediatingMesenchymalMesenchymasMesenchymeMiceMice MammalsMitogen-Activated Protein Kinase 3Mitogen-Activated Protein Kinase 3 GeneMitogen-Activated Protein Kinase GeneMitral ValveModelingModern ManMorphogenesisMurineMusMutant Strains MiceNuclearNucleusNull MouseP44ERK1PI-3 KinasePI3-KinasePI3CGPI3KGammaPI3kPIK3PIK3CGPIK3CG genePSTkinase p44mpkParturitionPathologyPathway interactionsPhenocopyPhenotypePhosphatidylinositol 3-KinasePhosphatidylinositol-3-OH KinasePhosphoinositide 3-HydroxykinasePhosphorylationPlayProcessProtein Kinase BProtein PhosphorylationProtein Tyrosine KinaseProtein Tyrosine Kinase EEKProto-Oncogene Proteins c-aktPtdIns 3-KinaseRAC-PK proteinRNA SeqRNA sequencingRNAseqRegulationRoleSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinTEK geneTIE-2TIE2TamoxifenTestingThinnessTimeTissue GrowthTranscription Factor Proto-OncogeneTranscription factor genesTricuspid ValveTricuspid valve structureType I Phosphatidylinositol KinaseType III Phosphoinositide 3-KinaseTyrosine KinaseTyrosine-Protein Kinase Receptor EEKTyrosine-Specific Protein KinaseTyrosylprotein KinaseVMCMVMCM1Valvular Heart DiseasesValvular Heart DisorderVariantVariationWorkabnormal heart developmentaortic valveautocrinebicuspid aortic valvebiological signal transductionc-akt proteincardiac failurecardiac valve diseasecardiac valve disordercardiac valvular diseasecausationconditional knock-outconditional knockoutconditional mutantconditional mutationcongenital anomalycongenital cardiac abnormalitycongenital cardiac anomaliescongenital cardiac diseasecongenital cardiac disordercongenital cardiac malformationcongenital heart abnormalitycongenital heart anomalycongenital heart diseasecongenital heart disordercongenital heart malformationcritical perioddegenerative valvular heart diseasedevelopmentaldisease causationembryo heartfloxedfloxed allelegain of functionheart valve disorderhydroxyaryl protein kinasein vivoinduced Creinducible Crekinase inhibitorlater in lifelater lifemorphogenetic processmouse mutantmutantontogenyoverexpressoverexpressionp44 MAPKparacrinepathwayprotein expressionproto-oncogene protein RACproto-oncogene protein aktrac protein kinaserelated to A and C-proteinscRNA sequencingscRNA-seqsemilunar valvesingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial roletranscription factortranscriptome sequencingtranscriptomic sequencingtyrosyl protein kinaseversican
Description preview
Abnormal valve development contributes to many common congenital heart malformations.
Developmental signaling events that regulate early valve formation have been studied extensively, however,
the mechanisms that underlie latter stages of remodeling to mature valves remain poorly understood. We have
recently identified a critical time point at the…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click