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The role of the microbiome in hepatic encephalopathy pathogenesis and treatment
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 15 Aug 2024Deadline 30 Jun 2025 ⚠️
NIHUS FederalResearch GrantFY20254-O-beta-D-galactopyranosyl-D-fructoseAddressAmmoniaApplications GrantsBacteriaBacterial TranslocationBiologicalBiopsyBrainBrain Nervous SystemBypassCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCephulacChronulacCirrhosisClinicalClinical InvestigatorClinical TrialsClinical Trials DesignCognitiveComplicationConfusionConfusional StateDataDiarrheaDrugsElectric ResistanceElectrical ResistanceEncephalonEndoscopyEnrollmentFatigueFecesFundingFutureGoalsGrant ProposalsGroup MeetingsGut Epithelial PermeabilityGut HyperpermeabilityGut permeabilityHepatic EncephalopathyHepatocerebral EncephalopathyHigh-dimensional ModelingHistoryImpairmentIntestinalIntestinal Epithelial PermeabilityIntestinal HyperpermeabilityIntestinal permeabilityIntestinesInvestigatorsK-AwardsK-Series Research Career ProgramsK23 AwardK23 MechanismK23 ProgramKnowledge acquisitionLack of EnergyLactuloseLeadLearningLiverMacrogolsMedicationMental ConfusionMentored Patient-Oriented Research Career Development AwardMentored Patient-Oriented Research Career Development Award (K23)MentorshipMicrobeModelingMucosaMucosal TissueMucous MembraneOccluding JunctionsOsmosisPathogenesisPathway interactionsPatientsPb elementPersonalityPersonsPharmaceutical PreparationsPlayPolyethylene GlycolsPolyethylene OxidePolyethyleneoxidePolyoxyethylenesPortal-Systemic EncephalopathyPortosystemic EncephalopathyPotatoPrevalenceProbabilistic ModelsProbability ModelsProductionProspective, cohort studyPsychometricsPublic HealthQOLQuality of lifeRandomizedRecording of previous eventsResearchResearch Career ProgramResearch DesignResearch PersonnelResearchersRoleShort-Chain Fatty AcidsStarchStatistical ModelsStudy TypeSymptomsSystems BiologyTestingTherapeuticTight JunctionsTrainingUnited StatesVenousVolatile Fatty AcidsWorkZonula Occludensbacteria in the gutbacterial communitybiologicbowelcirrhoticclinical careclinical practiceclinical predictorsclinical translationclinically translatablecognitive functionconferenceconventiondesigndesigningdetermine efficacydrug/agentefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationendoscopic imagingenrollevaluate efficacyexamine efficacyfecal microbial transplantationfecal microbiome transplantationfecal microbiota transplantfecal microbiota transplantationfecal transplantfecal transplantationgut bacteriaheavy metal Pbheavy metal leadhepatic body systemhepatic coma/encephalopathyhepatic organ systemhigh riskhistorieshospitalization ratesimprovedinsightintestinal barrierintestinal mucosal barriermetabolism measurementmetabolomemetabolomicsmetabonomemetabonomicsmetagenome sequencingmetagenomic sequencingmicrobialmicrobial consortiamicrobial floramicrobiomemicrobiome community compositionmicrobiome compositionmicrobiome sequencingmicrobiome species compositionmicrobiome structuremicrobiotamicrofloramortalitymotor diseasemotor disordermotor dysfunctionmultidimensional modelingmultiomicsmultiple omicsmultispecies consortianew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generationnext generation therapeuticsnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeuticsnovel therapypanomicspathwayprebioticspreventpreventingprimary outcomeprospectiveprotein expressionpsychologicpsychologicalrandomisationrandomizationrandomly assignedside effectskillssocial rolestandard of carestatistical linear mixed modelsstatistical linear modelsstoolstudy designsummitsymposiasymposiumtargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttranslational investigatortranslational researchertranslational scientist
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Project Summary/Abstract
Hepatic encephalopathy (HE) is a complication of cirrhosis characterized by cognitive, psychological, and
motor dysfunction that is associated with decreased quality of life and poor survival. Unfortunately, current
treatments for HE only have modest efficacy in preventing overt (or clinically apparent) HE episodes. Novel…
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