grant
The Role of the Exposome and Allostatic Load in Risk and Resilience to Youth Suicide Attempts
Organization CHILDREN'S HOSP OF PHILADELPHIALocation PHILADELPHIA, UNITED STATESPosted 1 Sept 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY202512-20 years oldAccident and Emergency departmentAccountingActive Follow-upAddressAdolescenceAdolescentAdolescent Risk BehaviorAdolescent YouthAgeBMIBMI percentileBMI z-scoreBiologicalBiological FunctionBiological ProcessBiologyBlood GlucoseBlood SugarBody mass indexBrainBrain Nervous SystemCausalityCause of DeathChildhoodChildren's HospitalClassificationClinicalCognitive DiscriminationComplexDataDiscriminationDisparitiesDisparityDistalEcologic MonitoringEcologic SystemsEcological MonitoringEcological SystemsEcosystemEmergency DepartmentEmergency roomEncephalonEnvironmentEnvironmental ExposureEnvironmental FactorEnvironmental MonitoringEnvironmental Risk FactorEthnic OriginEthnicityEtiologyExposure toFamilyFoundationsFutureGoalsHealth SurveysHeterogeneityHouseholdIndividualIndividuals from minorityIndividuals of minorityInterventionLifeLinkMapsMeasuresMediatingMental HealthMental HygieneMethodsMexicanMinority GroupsMinority PeopleMinority PopulationMinority individualModelingNIMHNational Institute of Mental HealthOutcomePathway interactionsPediatric HospitalsPhiladelphiaPhysiologicPhysiologicalPopulation HeterogeneityPredispositionProblem SolvingPsychological HealthPsychopathologyQuetelet indexRaceRacesReproducibilityResearchRiskRisk FactorsRoleRunningSamplingSchoolsSkinStatistical MethodsStressStructureSubgroupSuicideSuicide attemptSuicide precautionSuicide preventionSurvey InstrumentSurveysSusceptibilitySystemSystematicsTestingTimeTraumaWeightWorkYouthYouth 10-21Youth Risk Behaviorabnormal psychologyactive followupadolescence (12-20)adolescent mental healthadolescent risk takingagesallostatic loadbiologiccausationclinical relevanceclinical riskclinically relevantcognitive developmentcohortcyber bullyingcyberbullyingdimension reductiondimensionality reductiondisease causationdisparity in healthdiverse populationselectronic aggressionemotion regulationemotional regulationenvironmental riskenvironmental stressesenvironmental stressorenvironmental testingexperienceexposomeexposomicsfatal attemptfatal suicidefollow upfollow-upfollowed upfollowuphealth disparityheterogeneous populationhigh riskimprovedintent to diejuvenilejuvenile humanlarge scale datalarge scale data setslarge scale datasetslife-style factorlifestyle factorsmulti-modalitymultimodalitymultiomicsmultiple omicsnon fatal attemptnon-genomicnonfatal attemptnongenomicnovelpanomicspathwaypediatricpeerphysical conditioningphysical healthpopulation diversitypre-adolescentpreadolescencepreteenpreventprevent suicidalityprevent suicidepreventingprospectivepsychobiologicpsychobiologicalpsychologicpsychologicalracialracial backgroundracial originreduce data dimensionreduce dimensionalityresilienceresilience factorresiliency factorresilientresponserisk behavior in youthsexual minorityskillssocial rolestatistic methodssuicidal adolescentsuicidal adolescentssuicidal attemptsuicidal behaviorsuicidal risksuicidal youthsuicidal youthssuicidality preventionsuicide behaviorsuicide interventionsuicide risksuicidestheoriestooltranslational impactweightsyouth age
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ABSTRACT
Suicide is the second leading cause of death in US youth. Suicidal behavior is complex and is influenced by a
combination of multi-level distal and proximal environmental risk factors and lifestyle factors (i.e., exposome),
and biological susceptibility. Adverse exposome is key to youth suicide risk, and yet there is variability and most…
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