grant
THE ROLE OF SLC4A4 IN VASCULAR DEMENTIA
Organization BAYLOR COLLEGE OF MEDICINELocation HOUSTON, UNITED STATESPosted 7 Mar 2026Deadline 6 Jan 2029
NIHUS FederalResearch GrantFY20263-D Imaging3D imagingAblationAddressAffectAmentiaAmmon HornApoplexyArteriosclerotic DementiaAssayAstrocytesAstrocytusAstrogliaAutomobile DrivingAutopsyAutoregulationBehaviorBehavioralBicarbonatesBioassayBiological AssayBloodBlood - brain barrier anatomyBlood Reticuloendothelial SystemBlood VesselsBlood brain barrier dysfunctionBlood-Brain BarrierBody TissuesBrainBrain DiseasesBrain DisordersBrain Nervous SystemBrain VascularBrain Vascular AccidentBuffersCandidate Disease GeneCandidate GeneCell BodyCell Communication and SignalingCell CountCell NumberCell SignalingCellsCellular MorphologyCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeCerebrovascular systemChronicCognitionCognition DisordersCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive deficitsCognitive function abnormalCommunicationComplexCornu AmmonisDataDegenerative Neurologic DisordersDementiaDevelopmentDiseaseDisease ProgressionDisorderDisturbance in cognitionDysfunctionEncephalonEncephalon DiseasesEndothelial CellsEnvironmentEquilibriumFunctional disorderGenesGliaGlial CellsGlutamatesGoalsHCO3Hemato-Encephalic BarrierHippocampusHistologyHomeostasisHortega cellHumanHydrogen CarbonatesImpaired cognitionImpairmentInjectionsInjuryIntracellular Communication and SignalingIntracranial CNS DisordersIntracranial Central Nervous System DisordersIonsIschemic StrokeKO miceKnock-out MiceKnockout MiceKnowledgeKolliker's reticulumL-GlutamateLearningMaintenanceMediatingMemoryMemory DeficitMemory impairmentMiceMice MammalsMicrogliaModelingModern ManMolecularMorphologyMurineMusNa-HCO3 SymportNerve CellsNerve Transmitter SubstancesNerve UnitNervous System Degenerative DiseasesNervous System DiseasesNervous System DisorderNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurogliaNeuroglial CellsNeurologicNeurologic Degenerative ConditionsNeurologic DisordersNeurologicalNeurological DisordersNeuronal DysfunctionNeuronsNeurotransmittersNon-neuronal cellNonneuronal cellNull MouseO elementO2 elementOutcomeOxygenPathogenesisPathologicPathologyPathway interactionsPhenotypePhysiologicPhysiologicalPhysiological HomeostasisPhysiopathologyProteinsPublishingRNA SeqRNA sequencingRNAseqRegulationRisk FactorsRoleSamplingSignal TransductionSignal Transduction SystemsSignalingSodium Bicarbonate SymportSodium-Bicarbonate CotransporterSodium-Bicarbonate SymportersStrokeSynapsesSynapticTestingTherapeuticThree-Dimensional ImagingTissuesVascular DementiaVisualizationWild Type Mouseastrocytic gliabalancebalance functionbehavior outcomebehavioral outcomebiological signal transductionblood vessels in the brainbloodbrain barrierbrain attackbrain blood vesselsbrain cellbrain vascular pathologybrain vascular pathophysiologybrain vasculaturecell morphologycell typecellular pathologycerebral angiopathycerebral blood vesselcerebral vascularcerebral vascular accidentcerebral vascular pathologycerebral vasculaturecerebral vasculopathycerebro-vascularcerebrovascularcerebrovascular abnormalitycerebrovascular accidentcerebrovascular contributions to dementiacerebrovascular defectcerebrovascular disease pathologycerebrovascular pathologycerebrovascular pathophysiologycerebrovascular vesselscerebrovasculaturecerebrovasculopathycognitive defectscognitive diseasecognitive disordercognitive dysfunctioncognitive functioncognitive losscognitive syndromeconditional knock-outconditional knockoutdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentaldifferential expressiondifferentially expresseddrivingexcitotoxicexcitotoxicityextracellulargitter cellglial activationglial cell activationglutamatergichigh definitionhigh-resolutionhippocampalhypoperfusionimprovedin vivoinjuredinjuriesinjury recoverylearned behaviorlearning behaviormemory dysfunctionmesogliamicroglial cellmicrogliocytemouse modelmurine modelnecropsynerve cell deathnerve cell lossnerve cementneural dysfunctionneuro-vascular unitneurodegenerative illnessneurological diseaseneuron cell deathneuron cell lossneuron deathneuron lossneuronalneuronal cell deathneuronal cell lossneuronal deathneuronal lossneurovascular unitoverexpressoverexpressionpH Homeostasispathophysiologypathwayperivascular glial cellpharmacologicpostmortemrecovery after injuryrecovery following injuryrecovery post injuryresponsesocial rolestrokedstrokessynapsetherapeutic targettranscriptional differencestranscriptome sequencingtranscriptomic sequencingvascularvascular contributions in dementiavascular contributions to dementiavascular related dementiawildtype mouse
Description preview
ABSTRACT
Vascular dementia (VaD), the second most common subtype of dementia, is a neurological brain disorder in
which cognitive deficits are attributed to cerebrovascular pathologies. Cognitive impairment and neuronal
dysfunction are two of the major hallmarks of VaD. Throughout disease progression, vascular pathologies
change the integrity of…
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