grant
The role of sex chromosomes in neonatal hyperoxic lung injury
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Aug 2025Deadline 31 May 2028
NIHUS FederalResearch GrantFY202521+ years oldATAC sequencingATAC-seqATACseqAdultAdult HumanAffectAgeAirAlveolarAssay for Transposase-Accessible Chromatin using sequencingAsthmaAutomobile DrivingBiologyBirth WeightBlood VesselsBronchial AsthmaBronchopulmonary DysplasiaCUT&RUNCell BodyCell IsolationCell SegregationCell SeparationCell Separation TechnologyCellsChromatinChromosomesChronic lung diseaseCleavage Targets and Release Using NucleaseCleavage Under Targets and Release Using NucleaseComplicationDNA ContentDNA IndexDNA PloidyDataDependenceDevelopmentDifferences between sexesDiffers between sexesDisadvantagedDiseaseDisease OutcomeDisorderDisproportionate number of menDisproportionately impacts malesDisproportionately in menDosage CompensationDosage Compensation (Genetics)EmphysemaEndothelial CellsEndotheliumEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEuthanasiaExposure toFaceFemaleFoundationsFour Core GenotypesGender BiasGene ExpressionGene InactivationGene SilencingGenesGenotypeGestationGoalsGonosomesHumanHyperoxiaIncidenceIndividualInfantInflammationInjuryKnowledgeLifeLinkLungLung Respiratory SystemLung damageLyonizationMediatingMentorsMercy KillingMiceMice MammalsModern ManMurineMusNHLBINational Heart, Lung, and Blood InstituteNeonatalNeonatal lungO elementO2 elementOutcomeOvaryOxygenPhenotypePloidiesPregnancyPremature BirthPrematurely deliveringPreterm BirthPrevalenceProcessPromoter RegionsPromotor RegionsPulmonary EmphysemaRNA SeqRNA sequencingRNAseqResearchResolutionRoleSecondary toSeveritiesSex BiasSex ChromosomesSex DifferencesSexual differencesStrategic PlanningSurvivorsTesticlesTestingTestisTherapeuticTherapeutic InterventionTrainingUpregulationVascularizationWorkX ChromosomeX InactivationX-Chromosome InactivationY Chromosomeadulthoodagesassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbiological sex as a modifiercareercell sortingcell typechromosome complementchronic lung disease in infantschronic lung disease in neonatal infantschronic lung disease in neonateschronic lung disease in newbornschronic lung disease in prematuritychronic lung disease in preterm infantschronic lung disease of infancychronic lung disease of prematuritychronic pulmonary diseaseco-morbidco-morbiditycomorbiditycritical injurydevastating injurydevelopmentaldisproportionately affects malesdisproportionately affects mendisproportionately concentrated among mendisproportionately distributed among mendisproportionately higher among mendisproportionately impacts mendisproportionately occurs in mendosagedrivingemphysematousepigenetic regulationepigeneticallyfacesfacialgene signaturesgenetic promoter elementgenetic promoter sequencegenetic signatureglobal gene expressionglobal transcription profilegonad developmentgonad formationhistone demethylasehyperoxygenationimprovedinfant chronic lung diseaseinfants with chronic lung diseaseinjuriesinsightintervention therapyknock-downknockdownlung developmentlung functionlung healthlung injurymalemale biasmale predominancemen disproportionately diagnosedmen disproportionately experiencemen experience disproportionate ratesmorphometrymortalitymouse modelmultiomicsmultiple omicsmurine modelneonatal careneonatal chronic lung diseaseneonatal miceneonatal pulmonaryneonatenewborn chronic lung diseasenewborn lungnewborn pulmonarypanomicspost-prematurity respiratory diseasepostnatalprecision medicineprecision-based medicinepredominantly affecting menpremature childbirthpremature deliverypremature neonatespremature newbornprenatalpreterm deliverypreterm infants with chronic lung diseasepreterm neonatepreterm newbornpromoter sequenceprotective effectpulmonarypulmonary damagepulmonary functionpulmonary healthpulmonary injurypulmonary tissue damagepulmonary tissue injurypuprepairrepairedresilienceresilientresolutionsrespiratoryresponsescRNA sequencingscRNA-seqsevere injurysexsex as a biological factorsex as a biological measuresex as a biological risk factorsex as a biological variablesex as a biological variancesex as a biologically significant variablesex as a fundamental variablesex based differencessex dimorphismsex-dependent differencessex-related differencessex-specific differencessexual dimorphismsexually dimorphicsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesupplemental oxygentherapeutic targettranscriptional silencingtranscriptometranscriptome sequencingtranscriptomic sequencingunbornvascular♀♂
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PROJECT SUMMARY
Bronchopulmonary dysplasia (BPD) is the most common complication affecting preterm neonates and is
defined by supplemental oxygen dependence at 36 weeks postmenstrual age. Advances in neonatal care have
improved overall survival of preterm neonates though BPD prevalence continues to increase. BPD develops
after early-life lung…
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