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The role of Nrf2 in beta cell expansion during pregnancy
Organization BECKMAN RESEARCH INSTITUTE/CITY OF HOPELocation DUARTE, UNITED STATESPosted 1 Feb 2022Deadline 30 Nov 2025 โ ๏ธ
NIHUS FederalResearch GrantFY20250-4 weeks old21+ years oldAdultAdult HumanAdult-Onset Diabetes MellitusAffectApoptosisApoptosis PathwayBeta CellBiologyBlood GlucoseBlood SugarCapsulesCell FunctionCell Growth in NumberCell MultiplicationCell PhysiologyCell ProcessCell ProliferationCell SurvivalCell ViabilityCellular FunctionCellular PhysiologyCellular ProcessCellular ProliferationChIP SequencingChIP-seqChIPseqD-GlucoseDNA mutationDataData SetDefectDevelopmentDextroseDiabetes MellitusDiseaseDisorderFamily Medical HistoryFamily Medical History EpidemiologyFamily history ofFemaleFetusFutureGWA studyGWASGene ModifiedGenesGenetic ChangeGenetic defectGenetic mutationGestationGestational DiabetesGestational Diabetes MellitusGlucoseGoalsHumanHumulin RHyperlipemiaHyperlipidemiaHypertensionImpairmentInsulinInsulin CellInsulin ResistanceInsulin Secreting CellInvestigatorsKetosis-Resistant Diabetes MellitusKidneyKidney Urinary SystemKnowledgeKnowledge acquisitionMapsMaturity-Onset Diabetes MellitusMeasuresMediatingMethodologyMiceMice MammalsModelingModern ManMothersMurineMusMutationNIDDMNewborn InfantNewbornsNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin RObesityOvernutritionPathway interactionsPatientsPhysiologicPhysiologicalPolycystic Ovarian DiseasePolycystic Ovarian SyndromePolycystic Ovary SyndromePostpartum PeriodPregnancyPregnancy-Induced DiabetesPrevalenceProgrammed Cell DeathProliferatingRNA SeqRNA sequencingRNAseqRaceRacesRegular InsulinReportingResearch PersonnelResearchersRisk FactorsRoleSclerocystic Ovarian DegenerationSclerocystic Ovary SyndromeSlow-Onset Diabetes MellitusStable Diabetes MellitusSubcellular ProcessSurvey InstrumentSurveysT2 DMT2DT2DMTestingTherapeuticTimeTransplantationType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesVascular Hypertensive DiseaseVascular Hypertensive DisorderWritingadiposityadult onset diabetesadulthoodadvanced maternal ageadvanced reproductive ageadverse consequenceadverse outcomeafter pregnancyblood glucose regulationcapsulechromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingcorpulencedesigndesigningdevelopmentaldevelopmental diseasedevelopmental disorderdiabetesfetalgene modificationgenetically modifiedgenome mutationgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studyglucose controlglucose homeostasisglucose regulationglucose tolerancehigh blood pressurehyperpiesiahyperpiesishypertensive diseasehypertensive disorderimprovedin vivoinsightinsulin resistantinsulin secretioninsulin toleranceisletketosis resistant diabetesloss of functionmaternal riskmaturity onset diabetesnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynewborn childnewborn childrennovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathwaypolycystic ovarypolycystic ovary diseasepolycystic ovary disorderpost pregnancypost-partumpregnancy diabetespregnantprotective effectracialracial backgroundracial originrenalresponseskillssocial roletherapeutic targettranscriptome sequencingtranscriptomic sequencingtransplanttreatment strategytype 1 diabetictype 2 DMtype I diabetictype II DMtype two diabeteswhole genome association analysiswhole genome association studyฮฒ-cellฮฒ-cellsฮฒCellโ
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Summary
The late stages of the mammalian pregnancy are accompanied with increased insulin resistance due to the
increased glucose demand of the growing fetus. Therefore, as a compensatory response, in order to maintain
the maternal normal blood glucose levels, the beta cells mass expands leading to increased insulin release.
Beta cellโฆ
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