grant
The role of night shift work in metabolic disorders during and after pregnancy
NIHUS FederalResearch GrantFY2025(TNF)-α3-10CAMCF-IAbdominal DeliveryActive Follow-upAddressAdult-Onset Diabetes MellitusAeroseb-HCAffectAmericanAutoregulationB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBSF-2BSF2Biochemical PathwayBiologicalBiological MarkersBiometricsBiometryBiostatisticsBlood PlasmaC sectionCOBRECXCL8CachectinCenter of Biomedical Research ExcellenceCenters of Research ExcellenceCesareanCesarean sectionCetacortChronic DiseaseChronic IllnessChronologic Fetal MaturityCircadian DysregulationCircadian RhythmsCircadian desynchronyClinicalCohort StudiesComplementComplement ProteinsComplexConcurrent StudiesCort-DomeCortefCortenemaCortisolCortisprayCortrilDataDermacortDevelopmentDiabetes MellitusEatingEldecortEpidemicEpidemiologic ResearchEpidemiologic StudiesEpidemiological StudiesEpidemiologyEpidemiology ResearchFastingFetal AgeFetal MacrosomiaFetal MacrosomiasFood IntakeFundingFutureGCP1GestationGestational AgeGestational DiabetesGestational Diabetes MellitusHPGFHairHealthHepatocyte-Stimulating FactorHigh Risk WomanHomeostasisHybridoma Growth FactorHydrocortisoneHydrocortoneHyperglycemiaHypophysisHypophysis CerebriHypothalamic structureHypothalamusHytoneIFN-GammaIFN-beta 2IFN-gIFN-γIFNB2IFNGIFNγIL-6IL-8IL6 ProteinIL8IL8 geneImmune InterferonIndustryInflammationInflammatoryInsulin ResistanceInterferon GammaInterferon Type IIInterleukin-6Intermediary MetabolismIntervention StudiesIntervention TrialInterventional trialInvestigatorsK60Ketosis-Resistant Diabetes MellitusLeadLife StyleLifestyleLong-term prospective studiesMGI-2Macrophage-Derived TNFMaturity-Onset Diabetes MellitusMeasurementMeasuresMediationMentorsMesenchymalMetabolicMetabolic DiseasesMetabolic DisorderMetabolic NetworksMetabolic ProcessesMetabolic syndromeMetabolismMonocyte-Derived TNFMorbidityMorbidity - disease rateMothersMyeloid Differentiation-Inducing ProteinNIDDMNegotiatingNegotiationNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNurses' Health StudyNutracortNyctohemeral RhythmObesityOccupationalOutcomePb elementPhasePhysiciansPhysiological HomeostasisPituitaryPituitary GlandPituitary Nervous SystemPlasmaPlasma SerumPlasmacytoma Growth FactorPlayPregnancyPregnancy-Induced DiabetesPregnant WomenPrevalenceProctocortProspective StudiesProspective, cohort studyPublic HealthQuestionnairesResearchResearch MethodologyResearch MethodsResearch PersonnelResearchersReticuloendothelial System, Serum, PlasmaRiskRisk FactorsRoleSCYB8ScientistSleepSleep disturbancesSlow-Onset Diabetes MellitusStable Diabetes MellitusStatistical MethodsStressT2 DMT2DT2DMTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTSG-1TestingThesaurismosisTrainingTraining ActivityTumor Necrosis FactorTumor Necrosis Factor-alphaTwenty-Four Hour RhythmType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesWomanWorkaberrant sleepactive followupadiposityadult onset diabetesafter gestational diabetesafter pregnancyat-risk femalesat-risk womenawakeb-ENAPbio-markersbiologicbiologic markerbiological adaptation to stressbiomarkercareercareer developmentchildbearing agechronic disordercircadian abnormalitycircadian desynchronizationcircadian disruptioncircadian disturbancecircadian dysfunctioncircadian impairmentcircadian misalignmentcircadian processcircadian rhythmicitycohortcomplementationcorpulencedaily biorhythmday shiftdevelopmentaldiabetesdisrupted sleepdisturbed sleepearly in pregnancyearly pregnanciesearly pregnancyearly stage of pregnancyepidemiologicepidemiologic investigationepidemiologicalepidemiology studyexpectant motherexpectant womenexpecting motherexpecting womenexperienceexperimentexperimental researchexperimental studyexperimentsfastedfastsfemales at high riskfertile agefetal overgrowthfollow upfollow-upfollowed upfollowing gestational diabetesfollowupgestational diabetes historyheavy metal Pbheavy metal leadhigh riskhigh risk femaleshyperglycemichypothalamicimpaired sleepindividuals who are pregnantinsulin resistantinsulin toleranceinterferon beta 2intervention researchinterventional researchinterventional studyinterventions researchirregular sleepketosis resistant diabeteslFN-Gammalongitudinal, prospective studymalleable riskmaturity onset diabetesmetabolism disordermetabolism measurementmetabolomicsmetabonomicsmid lifemid-lifemiddle agemiddle agedmidlifemodifiable riskmortalityneural controlneural regulationneuromodulationneuromodulatoryneuroregulationnight shiftnight workpeople who are pregnantpost pregnancypregnancy diabetespregnantpregnant femalespregnant motherspregnant peoplepregnant populationspreventpreventingprogression riskprospectivereaction; crisisreproductivereproductive agereproductive epidemiologyreproductive yearsresearch and methodsrisk stratificationsecondary analysisshift workshiftworksleep amountsleep disruptionsleep durationsleep dysregulationsleep episodesleep intervalsleep lengthsleep periodsleep quantitysleep timesleep/wake disruptionsleep/wake disturbancesocial rolesocio-demographicssociodemographicsstatistic methodsstratify riskstress responsestress; reactionthose who are pregnanttime asleeptime during sleeptime in sleeptime spent asleeptime spent sleepingtraining moduletype 2 DMtype II DMtype two diabeteswomen at high riskwomen who are pregnant
Description preview
The role of night shift work in metabolic disorders during and after pregnancy
(I. Agarwal, Project Lead)
Gestational diabetes (GDM) is a large and growing epidemic resulting in significant morbidity and mortality to
both mothers and babies. GDM is a major risk factor for type II diabetes (T2DM), increasing the risk by 7-fold.
Factors that…
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