🗂️
Archived grant — no longer open
This grant has closed and is kept as a historical reference. Browse current grants for active opportunities.
grant
The Role of Neutrophils in Ischemia/Reperfusion Injury following Acute Stroke
Organization NORTHWESTERN UNIVERSITYLocation CHICAGO, UNITED STATESPosted 1 Jan 2023Deadline 31 May 2025 ⚠️
NIHUS FederalResearch GrantFY2025AbscissionAcuteAddressAdhesion MoleculeAdhesionsAffectAlteplaseAmericanAnimal ModelAnimal Models and Related StudiesAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAntibodiesApoplexyAreaBedsBindingBlocking AntibodiesBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood VesselsBlood flowBlood leukocyteBody TissuesBrainBrain HypoxiaBrain IschemiaBrain Nervous SystemBrain PathologyBrain Vascular AccidentBrain regionCD31CNS Nervous SystemCause of DeathCell Adhesion Molecule GeneCell Adhesion MoleculesCell BodyCell Communication and SignalingCell SignalingCell surfaceCellsCentral Nervous SystemCerebral IschemiaCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeCerebrovascular systemChemotactic CytokinesChronicClinicalClinical TrialsClottingCoagulationCoagulation ProcessDataDevelopmentEffectivenessEncephalonEndothelial CellsEndotheliumEventExcisionExtirpationExtravasationFellowshipHomologous Chemotactic CytokinesHypoxiaHypoxicImmuneImmunesInfarctionInfiltrationInflammationInflammatoryInflammatory ResponseInjuryIntercrinesIntracellular Communication and SignalingIschemiaIschemia-Reperfusion InjuryIschemic EncephalopathyIschemic StrokeLaboratoriesLeakageLeucocytic infiltrateLeukocyte CountLeukocyte NumberLeukocytesLeukocytes Reticuloendothelial SystemLifelong disabilityLocationManuscriptsMarrow NeutrophilMarrow leukocyteMediatorMethodsMiceMice MammalsMinorModelingMolecular InteractionMotorMurineMusMyeloid CellsNecrosisNecroticNervous System DiseasesNervous System DisorderNeuraxisNeurologic DisordersNeurological DisordersNeutrophilic GranulocyteNeutrophilic LeukocyteOutcomeOxygen DeficiencyPECAM1PECAM1 genePaperPathologicPathologyPathway interactionsPatientsPatternPermanent disabilityPhysiciansPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsRecombinant Tissue Plasminogen ActivatorRemovalReperfusion DamageReperfusion InjuryReperfusion TherapyResearchResolutionRodent ModelRoleSIS cytokinesScientistSignal TransductionSignal Transduction SystemsSignalingSpillageStrokeSurgical RemovalT-Plasminogen ActivatorTechniquesTestingTherapeuticTherapeutic EffectTherapeutic InterventionTimeTissue Activator D-44Tissue Plasminogen ActivatorTissue-Type Plasminogen ActivatorTissuesTrainingVisitWhite Blood Cell CountWhite Blood Cell Count procedureWhite Blood CellsWhite CellWorkacute cerebrovascular accidentacute strokeafter strokebiological signal transductionblood vessels in the brainbrain attackbrain blood vesselsbrain tissuebrain vasculaturecell adhesion proteincerebral blood vesselcerebral vascular accidentcerebral vasculaturecerebrovascular accidentcerebrovascular vesselscerebrovasculaturechemoattractant cytokinechemokineclinical relevanceclinically relevantcytokinedevelopmentaldisabilityimprovedimproved outcomein vivoinfarctinjuriesinsightintervention therapyintra-vital imagingintra-vital microscopyintravital imagingintravital microscopymigrationmodel of animalmortalityneurological diseaseneutrophilnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathwaypost strokepoststrokepre-clinical studypreclinical studypreventpreventingprotective effectrecruitreperfusionresectionresolutionsresponserestorationsocial rolespatial and temporalspatial temporalspatiotemporalstroke modelstroke outcomestroke therapystroke treatmentstrokedstrokest-PAtargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic targetthrombolysistreating strokevascularwhite blood cellwhite blood corpuscle
Applications closed.
Description preview
PROJECT SUMMARY/ABSTRACT
Inflammation is the body's response to tissue damage, including brain tissue after stroke. Stroke is one
of the leading causes of death and disability, affecting more that 795,000 Americans per year. A majority of
strokes are ischemic strokes, where blood flow to the brain is obstructed. Most therapeutic interventions…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click