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The Role of Negative Affect in the Cognitive-Behavioral Model of Avoidant/Restrictive Food Intake Disorder: An Integrated Analysis of Neural Circuitry, Hormones, and Momentary Negative Emotions

Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 1 Feb 2021Deadline 31 Jan 2026 ⚠️
NIHUS FederalResearch GrantFY202521+ years oldAddressAdultAdult HumanAeroseb-HCAffectAgeAmmon HornAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAnorexia NervosaAnteriorAnti-Anxiety AgentsAnti-Anxiety DrugsAnxietyAnxiety DisordersAnxiolytic AgentsAnxiolyticsAreaBehaviorBehavioral ModelBiologicalBrainBrain Nervous SystemBrain regionCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCell Communication and SignalingCell SignalingCentral LobeCetacortChronicCirculationClinicalCognitiveCompetenceCornu AmmonisCort-DomeCortefCortenemaCortisolCortisprayCortrilDSM-5DSM-VDSM5DataData AnalysesData AnalysisData CollectionDermacortDevelopmentDiagnostic and Statistical Manual of Mental Disorders, 5th editionDiagnostic and Statistical Manual of Mental Disorders-VEatingEating BehaviorEating DisordersEcological momentary assessmentEldecortEmotionalEmotional DepressionEmotionsEncephalonEndocrineEndocrine Gland SecretionExhibitsFastingFearFemaleFoodFood AversionFood IntakeFormulationFrequenciesFrightFunctional MRIFunctional Magnetic Resonance ImagingFundingGenderGeneralized GrowthGoalsGrowthHippocampusHormonalHormonesHydrocortisoneHydrocortoneHyperactivityHytoneIndividualInsulaInsula of ReilIntracellular Communication and SignalingIsland of ReilK-AwardsK-Series Research Career ProgramsMaintenanceMalnutritionMapsMedialMedicalMental DepressionMental HealthMental HygieneMentorsMethodologyMethodsMinor Tranquilizing AgentsMoodsMorbidityMorbidity - disease rateNegative ReinforcementsNeuranatomiesNeuranatomyNeuroanatomiesNeuroanatomyNeurobiologyNeurocognitiveNeuroendocrinologyNeurohormonesNutracortNutritional DeficiencyNutritional statusOcytocinOxytocinPathologyPatient Self-ReportPatternPeripheralPrefrontal CortexPrevalenceProctocortPsychological HealthPsychopathologyPublic HealthReceptor ProteinRecombinant OxytocinReportingReproducibilityResearchResearch Career ProgramResearch DesignRewardsRoleScientistSelf-ReportSensoryShapesSignal TransductionSignal Transduction SystemsSignalingStandardizationStimulusStressStudy TypeSymptomsTestingTherapeutic HormoneTimeTissue GrowthTrainingTreatment CostUndernutritionVariantVariationWeightYouthYouth 10-21abnormal psychologyadulthoodagesamygdaloid nuclear complexanxiety symptomsanxious symptomavoidant restrictive food intake disorderbiologicbiological adaptation to stressbiological signal transductionblood oxygen level dependentblood oxygenation level dependentcareer developmentcingulate cortexcognitive assessmentcognitive testingdata interpretationdepressiondepression symptomdepressivedepressive symptomsdesigndesigningdevelopmentaldietary deficiencyeating cuesemotion dysregulationemotion regulationemotional dysregulationemotional functioningemotional reactionemotional regulationfMRIfastedfastsfeedingfood avoidancefood cuesfood restrictionhippocampalhunger cuesinnovateinnovationinnovativeinterdisciplinary approachinterestmalemalnourishedmedical complicationmultidisciplinarymultidisciplinary approachnegative affectnegative affectivityneural circuitneural circuitryneurobiologicalneurocircuitrynutrition deficiencynutrition deficiency disordernutritional deficiency disorderontogenypatient oriented researchpatient oriented studyphysical conditioningphysical healthprogramspsychiatric co-morbiditypsychiatric comorbiditypsychosocialreaction; crisisreceptorresponserestrictive eatingsocial rolestress responsestress; reactionstudy designsynaptic circuitsynaptic circuitrytraitweightsyouth age♀♂

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PROJECT SUMMARY/ABSTRACT
Avoidant/restrictive food intake disorder (ARFID) is identified as a restrictive eating disorder in DSM-5 and is

associated with substantial medical morbidity, psychiatric comorbidity, and high treatment costs. Maintenance

mechanisms for ARFID are unknown. However, the cognitive behavioral model of ARFID suggests that…

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