grant
The role of monocyte metabolism and migration in inflammation-related reward circuit deficits and symptoms of anhedonia in people with HIV
NIHUS FederalResearch GrantFY2025AIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAdherenceAnhedoniaAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryApplications GrantsAssayBehaviorBehavioralBehavioral SymptomsBioassayBioenergeticsBiological AssayBiological MarkersBlood - brain barrier anatomyBlood PlasmaBlood monocyteBlood-Brain BarrierBrainBrain Nervous SystemBrain regionC-reactive proteinCell BodyCell Communication and SignalingCell LocomotionCell MigrationCell MovementCell SignalingCellsCellular MigrationCellular MotilityCerebrospinal FluidChemotactic CytokinesChronicClinicalClinical ResearchClinical StudyCognitive deficitsCorpus StriatumCorpus striatum structureDataDevelopmentDevelopment and ResearchDisease OutcomeDrug DesignDrugsDysfunctionEmotional DepressionEncephalonFunctional MRIFunctional Magnetic Resonance ImagingFunctional disorderFundingFutureGenus HippocampusGlycolysisGoalsGrant ProposalsHIVHIV SeronegativitiesHIV SeronegativityHIV negativeHTLV-III SeronegativitiesHTLV-III SeronegativityHemato-Encephalic BarrierHomologous Chemotactic CytokinesHortega cellHumanHuman Immunodeficiency VirusesIQ DeficitImmuneImmune Modulation TherapyImmune RegulatorsImmunesImmunomodulationImmunomodulatorsImpairmentIn VitroInflammationInflammatoryInflammatory ResponseIntercrinesIntermediary MetabolismIntracellular Communication and SignalingLAV-HTLV-IIILymphadenopathy-Associated VirusMarrow monocyteMeasuresMedialMedicalMedicationMental DepressionMental disordersMental health disordersMentorsMentorshipMetabolicMetabolic ProcessesMetabolismMicrogliaModern ManMotivationMyeloid CellsNIMHNational Institute of Mental HealthNeurocognitive DeficitNeuroimmuneNutrientOutcomeParentsPathology ReportPathway interactionsPatientsPeripheralPeripheral Blood InvolvementPersonsPharmaceutical PreparationsPhysiopathologyPlacebosPlasmaPlasma SerumPre-Clinical ModelPreclinical ModelsProcessProteins, specific or class, C-reactivePsychiatric DiseasePsychiatric DisorderPsychiatric therapeutic procedurePsychiatryR & DR&DResearchResearch ResourcesResourcesRestReticuloendothelial System, Serum, PlasmaRewardsRoleSIS cytokinesSeahorseSham TreatmentSignal TransductionSignal Transduction SystemsSignalingStriate BodyStriatumSymptomsTestingTherapeuticTrainingVirus-HIVantiretroviral therapyantiretroviral treatmentastrogliosisbio-markersbiologic markerbiological signal transductionbiomarkerbloodbrain barriercareercareer developmentcell motilitycerebral spinal fluidchemoattractant cytokinechemokinechip modelchip systemcognitive defectscytokinedeficits in reward learningdepressed patientdepressiondepression modeldepression symptomdepressivedepressive behaviordepressive modeldepressive symptomsdesigndesigningdevelopmentaldrug developmentdrug discoverydrug/agentexperiencefMRIgitter cellimmune modulationimmune modulatorsimmune modulatory therapiesimmune modulatory treatmentimmune regulationimmune regulation therapyimmune regulation treatmentimmune regulatory therapyimmune-modulation treatmentimmunologic reactivity controlimmunomodulation therapyimmunomodulation treatmentimmunomodulator therapiesimmunomodulator treatmentimmunomodulator-based therapiesimmunomodulatoryimmunomodulatory biologicsimmunomodulatory moleculesimmunomodulatory therapiesimmunomodulatory treatmentimmunoregulationimmunoregulatorimmunoregulatoryimmunoregulatory moleculesimmunoregulatory therapyimmunoregulatory treatmentinflammation markerinflammatory markerinhibitorinnovateinnovationinnovativeintelligence quotient deficitmental illnessmesogliamicroglial cellmicrogliocytemigrationmonocyteneural imagingneural inflammationneuro-imagingneurocognitive declineneurocognitive impairmentneuroimagingneuroinflammationneuroinflammatoryneurological imagingneuropsychiatricneuropsychiatric symptomneuropsychiatrynew approachesnovelnovel approachesnovel strategiesnovel strategyon a chipon chipparentpathophysiologypathwayperivascular glial cellprogramspsychiatric carepsychiatric co-morbiditypsychiatric comorbiditypsychiatric illnesspsychiatric symptompsychiatric therapypsychiatric treatmentpsychological disorderresearch and developmentreward circuit dysfunctionreward circuitryreward dysfunctionreward processingreward system dysfunctionsham therapysocial rolespinal fluidstriatalsymptom clustertherapeutic immunomodulationtherapeutic immunoregulationtherapeutic targettraffickingtranslation strategytranslational approachtranslational strategytreatment strategy
Description preview
PROJECT SUMMARY
The goal of this K01 is to determine the role of monocytes in HIV-related depressive symptoms with a focus on
immunometabolic mechanisms that may fuel monocyte activation and trafficking to the brain and serve as
therapeutic targets. Simultaneously, this mentored clinical research experience will provide me with essential
training…
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