grant
The role of microglia in developmental myelination
Organization UNIVERSITY OF COLORADO DENVERLocation Aurora, UNITED STATESPosted 1 May 2026Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2026AbscissionAction PotentialsAffectAnimalsAssayAxonBehavioralBindingBioassayBiologic ModelsBiological AssayBiological ModelsBrachydanio rerioBrainBrain Nervous SystemC 5b-9C1 qC1qC5b-9CNS Nervous SystemCell Communication and SignalingCell SignalingCentral Nervous SystemChimera ProteinChimeric ProteinsCommunicationComplementComplement 1qComplement C1qComplement Complex C5b-9Complement InactivatorsComplement InhibitorsComplement Membrane Attack ComplexComplement ProteinsCoupledCuesCytolytic Terminal Complement ComplexDanio rerioDegenerative Neurologic DisordersDepositDepositionDevelopmentDiseaseDisorderDorsalEncephalonEnsureEnvironmentExcisionExocytosisExperimental ModelsExtirpationFusion ProteinGenesGeneticGliaGlial CellsHealthHortega cellHumanImageImmune systemIndividualInjuryIntracellular Communication and SignalingKolliker's reticulumLarvaLeadLearningLengthMOG glycoproteinMacrophageMaintenanceMediatingMedulla SpinalisMembraneMembrane Attack ComplexMemoryMiceMice MammalsMicrogliaModel SystemModern ManMolecularMolecular InteractionMurineMusMyelinMyelin ProteinsMyelin SheathMφNerve CellsNerve UnitNervous System Degenerative DiseasesNervous System DiseasesNervous System DisorderNervous System PhysiologyNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeuraxisNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurogliaNeuroglial CellsNeurologic Degenerative ConditionsNeurologic DisordersNeurologic functionNeurological DisordersNeurological functionNeuronsNon-neuronal cellNonneuronal cellOligodendrocytesOligodendrocytusOligodendrogliaOligodendroglia CellPathologyPathway interactionsPb elementPhagocytosisPhagocytosis InhibitionPharmacogeneticsPopulationPositionPositioning AttributeProbabilityProcessProductionRegulationRemovalReporter GenesResearchRoleSignal TransductionSignal Transduction SystemsSignalingSpecificitySpinal CordSpinal Cord TractSurgical RemovalSurvey InstrumentSurveysSynapsesSynapticTerminal Complement ComplexTestingThickThicknessTransgenesTransgenic OrganismsVesicleVisualizationWorkZebra DanioZebra FishZebrafishbiological signal transductioncell typecompare to controlcomparison controlcomplement pathwaycomplementationdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdesigndesigningdevelopmentalexperiencegitter cellheavy metal Pbheavy metal leadimage-based methodimagingimaging in vivoimaging methodimaging modalityimaging studyimpaired brain developmentimprovedin vivoin vivo imaginginjuriesinsightmembrane structuremesogliamicroglial cellmicrogliocytemutantmyelin oligodendrocyte glycoproteinmyelinationnerve cementnervous system functionneural cell bodyneural circuitneural circuitryneurocircuitryneurodegenerative illnessneurological diseaseneuronalneuronal cell bodyoligodendrocyte differentiationoligodendrocyte-myelin glycoproteinpathwayperivascular glial cellprogramsresectionresponseselective expressionselectively expressedsocial rolesomastemsubstantia albasynapsesynaptic circuitsynaptic circuitrytooltransgenetransgenicwhite matter
Description preview
PROJECT SUMMARY
Myelin facilitates rapid and efficient conduction of action potentials and promotes the long-term health of axons.
The absence or loss of myelin consequently has tremendous effects on nervous system function as seen in
neurodegenerative diseases. Notably, myelin pathology and microglia activation often are coupled in
neurological…
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