grant
The role of inflammation in the regulation of immune response in acute myeloid leukemia
Organization NEW YORK UNIVERSITY SCHOOL OF MEDICINELocation NEW YORK, UNITED STATESPosted 6 Jul 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY20251.beta.-D-Arabinofuranosylcytosine21+ years oldAML - Acute Myeloid LeukemiaARA-cellATAC sequencingATAC-seqATACseqAcute Myeloblastic LeukemiaAcute Myelocytic LeukemiaAcute Myelogenous LeukemiaAcute leukemiaAdultAdult HumanAffectAlexanAnimal ModelAnimal Models and Related StudiesAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAntibodiesAntigenic DeterminantsArabineArabinofuranosylcytosineArabinosylcytosineAracytidineAracytinAracytineAssay for Transposase-Accessible Chromatin using sequencingAtlasesB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellB-cell receptor repertoire sequencingB-cell receptor sequencingBCR repertoire sequencingBCR seqBCR sequencingBCRseqBinding DeterminantsBlast CellBlood Precursor CellBlood monocyteBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemBone remodelingCITE sequencingCITE-seqCITEseqCancersCell BodyCell Communication and SignalingCell SignalingCellsCellular Indexing of Transcriptomes and Epitopes by SequencingCensusesCerubidinChromatinClinicalClonalityCollectionCoupledCytarabineCytarabinumCytarbelCytosarCytosar-UCytosarUCytosine ArabinosideCytosine-.beta.-arabinosideDNA mutationDataDauno-RubidomycineDaunoblastinaDaunoblastineDaunomycinDaunorrubicinaDaunorubicinDevelopmentDiseaseDisease ProgressionDisorderEpitopesErpalfaEventExhibitsGene ExpressionGenerationsGenesGeneticGenetic ChangeGenetic defectGenetic mutationGenomicsGenotypeGoalsHematopoietic Progenitor CellsHematopoietic stem cellsHumanIL-1IL1IL1RIL1R1IL1R1 geneIL1RAIRAKIRAK1IRAK1 geneImmuneImmune responseImmune systemImmunesImmunocompetentImmunomodulationInferiorInflammationInflammation MediatorsInflammatoryInflammatory ResponseInterleukin IInterleukin-1Interleukin-1 Receptor-Associated Kinase 1Intracellular Communication and SignalingLeukaemomycin CLeukemic CellLymphocyte-Stimulating HormoneMacrophage Cell FactorMalignantMalignant - descriptorMalignant CellMalignant NeoplasmsMalignant TumorMarrow monocyteMediatingMediatorMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMiceMice MammalsModelingModern ManMolecularMurineMusMutateMutationMyeloid CellsMyeloid DiseaseMyeloid MalignancyMyeloid NeoplasmMyeloid TumorMyeloproliferative DisordersMyeloproliferative TumorsMyeloproliferative diseaseOndenaOther GeneticsOutcomePatientsPhenotypePlayPopulationPredispositionRNA SeqRNA sequencingRNAseqRegimenResolutionRiskRoleRubidomycinRubilemRubomycinRubomycin CSamplingSignal TransductionSignal Transduction SystemsSignalingSpecificityStructureSubgroupSupporting CellSurface ProteinsSusceptibilityT Helper FactorT-CellsT-LymphocyteTarabine PFSTestingTherapeuticTimeTissuesTreatment ProtocolsTreatment RegimenTreatment ScheduleUdicilacute granulocytic leukemiaacute myeloid leukemiaadulthoodassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbiological signal transductionblood cell progenitorblood progenitorblood stem cellblood-forming stem cellcancer cellcancer microenvironmentcancer progressioncell transformationcellular indexing of transcriptomes and epitopes by single cell sequencingcerubidinecohortdesigndesigningdevelopmentaleffectiveness testingexome sequencingexome-seqgenome mutationglobal gene expressionglobal transcription profilehematopoietic progenitorhematopoietic stem progenitor cellhemopoietic progenitorhemopoietic stem cellhost responseimmune competentimmune microenvironmentimmune modulationimmune regulationimmune system responseimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseimmunosuppressive microenvironmentimmunosuppressive tumor microenvironmentimprovedindexinginflammatory mediatorinhibitorinsightleukemialeukemogenesislymphocyte activating factormalignancymodel of animalmonocytemouse modelmultiomicsmultiple omicsmurine modelmyeloproliferative neoplasmneoplasm progressionneoplasm/cancerneoplastic progressionnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpanomicspellepreventpreventingprotein expressionresolutionsresponseresponse to therapyresponse to treatmentscATAC sequencingscATAC-seqscRNA sequencingscRNA-seqsingle cell ATAC-seqsingle cell ATAC-sequencingsingle cell Assay for Transposase Accessible Chromatin sequencingsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell sequencing assay for transposase accessible chromatinsingle cell technologysingle cell transcriptomic profilingsingle-cell Assay for Transposase-Accessible Chromatin with sequencingsingle-cell RNA sequencingsingle-cell assay for transposase-accessible chromatin using sequencingsingle-cell assay for transposase-accessible chromatin-seqsocial rolestandard of caresurvival outcometargeted agenttherapeutic responsetherapy responsethymus derived lymphocytetranscriptometranscriptome sequencingtranscriptomic sequencingtransformed cellstreatment effecttreatment responsetreatment responsivenesstumortumor immune microenvironmenttumor microenvironmenttumor progressiontumor-immune system interactions
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Project Summary/Abstract
Survival outcomes of acute myeloid leukemia (AML) patients are negatively affected by high inflammation in the
bone marrow compared to low inflammation patients within the same molecular subgroup. The overarching goal
of our study is to delineate functionally relevant contributors to aberrant inflammation, characterize…
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