grant
The role of glycosylation in cell-state transitions during development and disease
Organization UNIVERSITY OF MISSISSIPPILocation UNIVERSITY, UNITED STATESPosted 15 May 2020Deadline 31 May 2030
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult HumanAnabolismAreaBiochemicalBioinformaticsBiologic ModelsBiological ModelsBiologyBody TissuesBrachydanio rerioCOBRECancerousCardiacCardiac DiseasesCardiac DisordersCardiac MalformationCardiac Muscle CellsCardiac MyocytesCardiac VentriclesCardiac defectCardiac developmentCardiocyteCardiomyopathiesCell BodyCell CoatCell DifferentiationCell Differentiation processCell FunctionCell LocomotionCell MigrationCell MovementCell PhysiologyCell ProcessCell membraneCell-Extracellular MatrixCellsCellular FunctionCellular MigrationCellular MotilityCellular PhysiologyCellular ProcessCellular TransformationCenter of Biomedical Research ExcellenceCenters of Research ExcellenceCold-Insoluble GlobulinsCompensationCongenital Cardiac DefectsCongenital Heart DefectsCytoplasmic MembraneDanio rerioDataDefectDevelopmentDiabetes MellitusDiseaseDisorderECMEmbryopathyEnvironmentExperimental DesignsExtracellular MatrixFN1Fibronectin 1FibronectinsFibrosisFibrosis in the heartFibrosis in the myocardiumFibrosis within the heartFibrosis within the myocardiumFibrotic myocardiumFundingGene ExpressionGeneticGenetic TechnicsGenetic TechniquesGestationGlobal ChangeGlycansGlycobiologyGlycocalyxGlycoproteinsGoalsHeartHeart DiseasesHeart MalformationHeart Muscle CellsHeart VentricleHeart myocyteHyperglycemiaImageImaging DeviceImaging InstrumentImaging ToolIndividualIntermediary MetabolismIsoformsLETS ProteinsLaboratoriesLarge External Transformation-Sensitive ProteinLinkMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMentorsMentorshipMesodermMetabolic GlycosylationMetabolic ProcessesMetabolismMicroscopyMissionModel SystemModelingModificationMolecularMorphologyMyocardialMyocardial DiseasesMyocardial DisorderMyocardiopathiesMyofibrilsN-Acetylneuraminic AcidsNamesNutrientOpsonic GlycoproteinOpsonic alpha(2)SB GlycoproteinPathogenesisPathogenicityPathologicPathway interactionsPatientsPhysiologyPilot ProjectsPlasma MembranePlayPolysaccharidesPregnancyProgenitor CellsProtein IsoformsProteinsReactionResearchResolutionRoleSCmRNAseqSialic AcidsSingle cell mRNA seqSubcellular ProcessTechnical ExpertiseTestingTissuesTubeVisualizationZebra DanioZebra FishZebrafishabnormal heart developmentadulthoodalpha 2-Surface Binding Glycoproteinbiophysical characteristicsbiophysical characterizationbiophysical measurementbiophysical parametersbiophysical propertiesbiosynthesiscardiac fibrosiscardiogenesiscardiomyocytecell motilitycellular differentiationcongenital cardiac abnormalitycongenital cardiac anomaliescongenital cardiac diseasecongenital cardiac disordercongenital cardiac malformationcongenital heart abnormalitycongenital heart anomalycongenital heart diseasecongenital heart disordercongenital heart malformationcoronary fibrosisdevelopmentaldiabetesdiabetic cardiomyopathydiabetic cardiopathydiabetic cardiopathy diseasediabetic cardiopathy disorderdiabetic cardiovascular diseasediabetic cardiovascular disorderdisease modeldisorder modelepithelial to mesenchymal transitionfetalfetal hyperglycemiafibrotic heartglycosylationheart defectheart developmentheart disorderheart fibrosisheart formationhyperglycemicimaginginnovateinnovationinnovativeinsightmaternal diabetesmetaplastic cell transformationmyocardial fibrosismyocardium diseasemyocardium disordernamenamednamingpathwaypilot studyplasmalemmaresolutionssingle cell mRNA sequencingsocial rolestem cellstechnical skills
Description preview
Project Summary
Cell-state transitions involve the coordinated transformation of cellular identity, physiology, and morphology.
These cellular processes occur at pivotal points in cardiac development and in the pathogenesis of cardiac
disease. Glycans have a vital role in cardiac development as revealed by the high percentage of cardiac…
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