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The Role of Enteric Infection in Flares of Inflammatory Bowel Disease

Organization NEW YORK UNIVERSITY SCHOOL OF MEDICINELocation NEW YORK, UNITED STATESPosted 15 Jan 2021Deadline 28 Feb 2026 โš ๏ธ
NIHUS FederalResearch GrantFY202516S RNA sequencing16S RNAseq16S gene sequencing16S rDNA amplicon sequencing16S rRNA DNA sequencing16S rRNA amplicon sequencing16S rRNA gene amplicon sequencing16S rRNA gene sequencing16S rRNA genomic profiling16S rRNA sequencing16S ribosomal RNA gene sequencing16S ribosomal RNA sequencing16S seq16S sequencing16s rRNA seqAcuteAffectAlimentary CanalAmericanAnimal ModelAnimal Models and Related StudiesAssayBioassayBiochemicalBiological AssayBiometricsBiometryBiopsyBiostatisticsC diffC difficileC. diffC. difficileCD8CD8BCD8B1CD8B1 geneCharacteristicsChronicClinicalClinical ManagementClostridioides difficileClostridium difficileComplexCrohn diseaseCrohn'sCrohn's diseaseCrohn's disorderDataDevelopmentDigestive TractDiseaseDisease OutcomeDisease ProgressionDisease remissionDisorderE coliE. coliEPECEnvironmentEnvironmental FactorEnvironmental Risk FactorEscherichia coliEvaluationFecesFlareFrequenciesFundingGI TractGI microbiomeGastroenteritisGastrointestinal TractGastrointestinal tract structureGoalsGranulomatous EnteritisHelper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHospital AdmissionHospitalizationImmuneImmune responseImmunesImmunologic FactorsImmunological FactorsImmunologyImmunosuppressionImmunosuppression EffectImmunosuppressive EffectIndividualInducer CellsInducer T-LymphocytesInfectionInflammationInflammatoryInflammatory Bowel DiseasesInflammatory Bowel DisorderInterventionIntestinal MucosaKnowledgeLYT3Lamina PropriaMentorsMethodsMicrobiologyMolecularMucosaMucosal ImmunityMucosal TissueMucous MembraneNorovirusNorwalk-like VirusesOperative ProceduresOperative Surgical ProceduresOutcomePatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPersonalized medical approachPolymerase Chain ReactionPositionPositioning AttributeQOLQuality of lifeRadiographyRecurrenceRecurrentRecurrent diseaseRelapseRelapsed DiseaseRemissionResearchRibosomal RNA GenesRiskRoentgenographyRoleSalmonellaSeveritiesSurgicalSurgical InterventionsSurgical ProcedureTechnologyTestingTherapeuticTrainingUlcerated ColitisUlcerative Colitisalimentary tractanalyzing longitudinalanti-microbialantimicrobialbowel inflammationclinical diagnosiscohortdevelopmentaldigestive canaldigestive tract microbiomedisease riskdisorder riskdysbacteriosisdysbiosisdysbioticeleocolitisenteral infectionenteral pathogenenteric infectionenteric microbiomeenteric pathogenenteric pathogen infectionenteropathogenenteropathogen infectionenteropathogenic E colienteropathogenic E. colienteropathogenic E.colienteropathogenic Escherichia colienteropathogenic infectionenvironmental riskexpression subtypesgastrointestinalgastrointestinal infectiongastrointestinal microbiomegut inflammationgut microbiomegut-associated microbiomehigh riskhost responseimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmunologic substanceimmunological substanceimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedindividualized approachinfected with enteropathogeninfection managementinflamed bowelinflamed gutinflamed intestineinflammatory disease of the intestineinflammatory disorder of the intestineinnovateinnovationinnovativeintestinal autoinflammationintestinal biomeintestinal infectionintestinal inflammationintestinal microbiomeintestinal pathogenintestine infectionintestine pathogenlongitudinal analysismicrobialmicrobial imbalancemodel of animalmolecular sub-typesmolecular subsetsmolecular subtypesmultidisciplinarynew approachesnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel approachesnovel strategiesnovel strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachoutcome predictionpathogenpatient centeredpatient orientedpatient oriented outcomespatient profilepersonalized approachpolarized cellpopulation basedprecision approachprofiles in patientsprospectiverRNA Genesradiological imagingrecruitregional enteritisscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestoolsurgerytailored approachtranslational investigatortranslational researchertranslational scientist

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PROJECT SUMMARY AND ABSTRACT
Inflammatory bowel diseases (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), are chronic,

progressive, inflammatory conditions of the gastrointestinal tract that affect up to 3 million Americans. IBD is

thought to be driven by inappropriate immune responses to an altered gut microbiome, or dysbiosis,โ€ฆ

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