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The role of EMT transcription factor Zeb2 in fetal hematopoiesis
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 May 2023Deadline 30 Apr 2026 โ ๏ธ
NIHUS FederalResearch GrantFY202521+ years oldATAC sequencingATAC-seqATACseqAddressAdultAdult HumanAllelesAllelomorphsAssayAssay for Transposase-Accessible Chromatin using sequencingAutoregulationBasal Transcription FactorBasal transcription factor genesBindingBinding SitesBioassayBiological AssayBlood Precursor CellBlood erythrocyteBlood megakaryocyteBlood monocyteBody TissuesBrainBrain Nervous SystemCRISPRCRISPR/Cas systemChromatinCitrucelClustered Regularly Interspaced Short Palindromic RepeatsCombining SiteDataDefectDeveloping fetusDevelopmentDiseaseDisorderDoctor of PhilosophyEmbryoEmbryo DevelopmentEmbryogenesisEmbryonicEmbryonic DevelopmentEncephalonEndotheliumEnhancer ElementsEnhancersErythrocytesErythrocyticErythroidErythropoiesisExhibitsFetal DevelopmentFetal LiverFetusFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneticGenetic Enhancer ElementGenetic TranscriptionGenetics-MutagenesisGestationGoalsHarvestHealthHematopoiesisHematopoieticHematopoietic Cellular Control MechanismsHematopoietic Progenitor CellsHematopoietic stem cellsHepatic CellsHepatic Parenchymal CellHepatocyteHeterogeneityHistoryHomeo BoxesHomeoboxHomeostasisHortega cellIn VitroInfectionInstitutionKO miceKnock-out MiceKnockout MiceKnowledgeLiver CellsLoxP-flanked alleleMGF Stem Cell FactorMacrophageMaintenanceMarrow erythrocyteMarrow monocyteMast Cell Growth FactorMegakaryocytesMegalokaryocyteMentorsMethyl CelluloseMethylcelluloseMiceMice MammalsMicrogliaMolecular InteractionMurineMusMutagenesisMutagenesis Molecular BiologyMyelogenousMyeloidMyeloid ProgenitorMyeloid Progenitor CellsMyeloid Stem CellsMฯNGS MethodNGS systemNull MousePh.D.PhDPhenotypePhysiciansPhysiological HomeostasisPopulationPregnancyRNA ExpressionReactive SiteRecording of previous eventsRed Blood CellsRed CellRegulatory ElementReporterRetroviridaeRetrovirusesRoleScientistSiteSortingSourceSteel FactorStem Cell DevelopmentStem Cell FactorSurfaceSystemTechnologyTissuesTrainingTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationTransgenic OrganismsTravelUniversitiesVirus-RetrovirusWashingtonYolk SacZinc Finger DomainZinc Finger MotifsZinc Fingersadulthoodassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingblood cell formationblood cell progenitorblood corpusclesblood progenitorblood stem cellblood-forming stem cellc-kit Ligandcareer developmentclinical developmentdevelopmentalenhancer sequenceerythroid developmenterythroid differentiationexperiencefetalflow cytophotometryfloxedfloxed allelegenetic enhancer sequencegitter cellhematopoietic progenitorhematopoietic stem progenitor cellhemopoietichemopoietic progenitorhemopoietic stem cellhistone modificationhistoriesin vivokit Ligandmedical collegemedical schoolsmesogliamethyl ether Cellulosemicroglial cellmicrogliocytemonocytemouse modelmurine modelmyeloid precursormyeloid stem and progenitor cellnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynext gen sequencingnext generation sequencingnextgen sequencingnovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachperivascular glial cellprogenitorprogenitor cell developmentprogenitor cell differentiationprogenitor developmentprogenitor differentiationprogramsscRNA sequencingscRNA-seqschool of medicinesingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestem and progenitor cell developmentstem and progenitor differentiationstem cell derived tissuesstem cell differentiationtranscription factortransgenicvectorvitelline sac
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Description preview
PROJECT SUMMARY
Our goal is to understand the transcriptional requirements for erythroid-myeloid progenitor (EMP)
development and differentiation into monocytes and tissue resident macrophages (TRM).
Hematopoiesis is comprised of three waves: primitive hematopoiesis, transient-definitive hematopoiesis and
definitive hematopoiesis1โ6.โฆ
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