grant
The role of early oncogenic drivers in maintaining lineage fidelity in prostate cancer
Organization WEILL MEDICAL COLL OF CORNELL UNIVLocation NEW YORK, UNITED STATESPosted 1 Jun 2025Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY2025AffectAfter CareAfter-TreatmentAftercareAndrogen ReceptorAndrogenic AgentsAndrogenic CompoundsAndrogensAntioncogene Protein p53BackBiologic ModelsBiologicalBiological MarkersBiological ModelsBiologyCancersCellular Tumor Antigen P53CharacteristicsChromatinClinicalClinical TrialsDNA AlterationDNA Sequence AlterationDNA mutationDataDependenceDiseaseDisorderDorsumEndocrine TherapyEquilibriumEvolutionFoundationsGEM modelGEMM modelGene TranscriptionGenetic AlterationGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenetically Engineered MouseHistologicHistologicallyHormonal TherapyHumanIn VitroInstitutionInvestigatorsMaintenanceMalignant NeoplasmsMalignant TumorMalignant neoplasm of prostateMalignant prostatic tumorMediatingMediatorModel SystemModelingModern ManMolecularMutationNatural HistoryNeuroendocrineNeuroendocrine SystemNeurosecretory SystemsOncogenicOncoprotein p53OrganoidsP53Pathway interactionsPatientsPatternPhenotypePhosphoprotein P53Phosphoprotein pp53Precision therapeuticsPreventative strategyPrevention strategyPreventive strategyProstateProstate CAProstate CancerProstate GlandProstate malignancyProstatic GlandProtein TP53RB1RB1 geneRNA ExpressionReceptor SignalingRecurrenceRecurrentResearch PersonnelResearchersResistanceRoleSamplingSequence AlterationShapesSignal PathwaySpecificityTP53TP53 geneTRP53TherapeuticTherapeutic AndrogenTimeTranscriptionTranscription ProcessTranscriptional ControlTranscriptional RegulationTumor Protein p53Tumor Protein p53 GeneTumor Subtypeandrogen dependentandrogen independent prostate cancerandrogen indifferent prostate cancerandrogen insensitive prostate cancerandrogen resistance in prostate cancerandrogen resistant prostate cancerandrogen responsiveandrogen sensitivebalancebalance functionbio-markersbiologicbiologic markerbiomarkercastration resistant CaPcastration resistant PCacastration resistant prostate cancerclinical relevanceclinically relevantepigenomicsgenetically engineered mouse modelgenetically engineered murine modelgenome mutationgenomic alterationhormone refractory prostate cancerhormone therapyhuman datain vivo Modelinnovateinnovationinnovativeinsightmalignancymouse modelmultidisciplinarymurine modelmutantneoplasm/cancernovelp53 Antigenp53 Genesp53 Tumor Suppressorpathwaypersonalized health interventionpersonalized interventionpost treatmentprecision interventionsprecision therapiesprecision treatmentpreventpreventingprogramsprostate cancer modelprostate cancer resistant to androgenprostate tumor modelprotein p53receptor functionresistance mechanismresistance to therapyresistantresistant mechanismresistant to therapyresponseretinoblastoma-1single cell analysissocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic resistancetherapy resistanttimelinetranscriptomicstreatment resistancetreatment strategytumor
Description preview
PROJECT SUMMARY/ABSTRACT
Prostate cancer (PCa) is a clinically and molecular heterogenous disease, with biologically distinct subtypes
driven by characteristic genomic alterations in both early, untreated disease and treatment resistant castration-
resistant prostate cancer (CRPC). However, whether early alterations affect fidelity to prostate…
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