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The Role of BNIP3 in Lipid Homeostasis in the Liver
Organization UNIVERSITY OF CHICAGOLocation CHICAGO, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY202521+ years oldAblationAccountingAdeno-Associated VirusesAdultAdult HumanAffectAutomobile DrivingAutophagocytosisAutoregulationCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessCentral VeinCharacteristicsCirrhosisDataDependoparvovirusDependovirusDevelopmentDiseaseDisease ProgressionDisorderExhibitsExpression SignatureFastingFatty LiverFluorescence Activated Cell Sorting FractionationFluorescence-Activated Cell SortingFluorescence-Activated Cell SortingsFutureGEM modelGEMM modelGene ExpressionGene Expression ProfileGeneticGenetically Engineered MouseGoalsHCC cellHCC cell lineHep G2HepG2HepG2 cell lineHepaticHepatic CellsHepatic DisorderHepatic ParenchymaHepatic Parenchymal CellHepatic TransplantationHepatocarcinomaHepatocellular CarcinomaHepatocellular cancerHepatocyteHepatomaHomeostasisHourHumanImage AnalysesImage AnalysisIn VitroLinkLipidsLiverLiver CellsLiver Cells CarcinomaLiver GraftingLiver SteatosisLiver TransplantLiver diseasesLiver parenchymaLysosomesMachine LearningMediatingMediatorMembraneMetabolicMiceMice MammalsMitochondriaModern ManMolecularMorphologyMurineMusNAFLDNASHNutrientObesityOnset of illnessOutputPathway interactionsPatternPhysiological HomeostasisPopulationPortal VeinPortal vein structurePrimary carcinoma of the liver cellsProcessProteinsReceptor ProteinRegulationRisk FactorsRoleSeveritiesSortingStressSubcellular ProcessTestingTherapeutic InterventionTimeWestern WorldWorkadeno associated virus groupadiposityadulthoodanalysis pipelineautophagycirrhoticcorpulencedevelopmentaldisease onsetdisorder onsetdrivingfastedfastsfat metabolismfatty liver diseasegene expression patterngene expression signaturegenetically engineered mouse modelgenetically engineered murine modelhepatic body systemhepatic diseasehepatic organ systemhepatic steatosishepatocellular carcinoma cell linehepatopathyhepatosteatosisimage evaluationimage interpretationin vivoinsightintervention therapyknock-downknockdownlipid metabolismliver carcinomaliver disorderliver transplantationmachine based learningmembrane structuremitochondrialmitochondrial autophagynew approachesnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnon-alcohol fatty livernon-alcohol fatty liver diseasenon-alcohol induced steatohepatitisnon-alcoholic fatty livernon-alcoholic fatty liver diseasenon-alcoholic liver diseasenon-alcoholic steato-hepatitisnon-alcoholic steatohepatitisnonalcohol fatty livernonalcoholic fatty livernonalcoholic fatty liver diseasenonalcoholic steato-hepatitisnonalcoholic steatohepatitisnovelnovel approachesnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel strategiesnovel strategynovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetnutrient deprivationnutritional deprivationobese patientsoverexpressoverexpressionpathwaypatients with obesitypreventpreventingreceptorresponsesocial roletooltranscriptional profiletranscriptional signature
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PROJECT SUMMARY
Non-Alcoholic Fatty Liver Disease (NAFLD) and the more severe Non-Alcoholic Steatohepatitis (NASH) are
driving increased rates of cirrhosis and hepatocellular carcinoma in the USA. Though obesity is a known risk
factor, the overlap between patients with obesity and NAFLD is incomplete, and a full understanding of the
mechanisms…
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